Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Christopher D. McMahon"'
Autor:
K. Singh, Carina Mallard, Gagandeep Singh-Mallah, Jian Guan, Dali Kang, Christopher D. McMahon, Maryam Ardalan
Publikováno v:
Nutritional Neuroscience. 25:2517-2527
Cyclic glycine-proline (cGP) is a natural nutrient of breast milk and plays a role in regulating the function of insulin-like growth factor-1 (IGF-1). IGF-1 function is essential for post-natal brain development and adult cognitive function. We evalu
Autor:
Jenny M. Oldham, Kenneth G. Matthews, Mark Thomas, Heather K. Smith, Kim Whiteman, Christopher D. McMahon, Ferenc Jeanplong, Shelley J. Falconer, Trevor Watson, Ryan G. Paul
Publikováno v:
Journal of Endocrinology. 248:207-220
Insulin-like growth factor-1 (IGF1) is crucial for regulating post-natal growth and, along with myostatin (MSTN), regulates muscle size. Here, we sought to clarify the roles of these two genes in regulating sexually dimorphic growth of body and muscl
Publikováno v:
Skeletal Muscle, Vol 9, Iss 1, Pp 1-13 (2019)
Skeletal Muscle
Skeletal Muscle
Background Sexually dimorphic growth has been attributed to the growth hormone (GH)/insulin-like growth factor 1 (IGF1) axis, particularly GH-induced activation of the intracellular signal transducer and activator of transcription 5B (STAT5B), becaus
Autor:
Heather K Smith, Kenneth G Matthews, Jenny M Oldham, Ferenc Jeanplong, Shelley J Falconer, James J Bass, Mônica Senna-Salerno, Jeremy W Bracegirdle, Christopher D McMahon
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e94356 (2014)
Skeletal muscles of myostatin null (Mstn(-/-)) mice are more susceptible to atrophy during hind limb suspension (HS) than are muscles of wild-type mice. Here we sought to elucidate the mechanism for this susceptibility and to determine if Mstn(-/-) m
Externí odkaz:
https://doaj.org/article/8a5f4e4b6c694a08806bf26ee71f3e17
Autor:
Yutaka Taguchi, Noriyuki Maeda, Noboru Ota, Kenji Mukawa, Yoshiro Kanmera, Yuji Shiotsuka, Koki Hayasaki, Ryoichi Fujino, Christopher D. McMahon, Hideyuki Takahashi, Hirokuni Miyamoto, Arisa Tsuboi, Y. Inabu, Tetsuji Etoh, Seiji Yamasaki
Publikováno v:
Animal Science Journal. 92
We evaluated the effects of feeding high volumes of milk replacer on growth and reproductive performances in Japanese black heifers. Fifty-one heifers were fed milk replacer at 9 L/day for 60 days (9 L × 60 days; n = 18) or 41 days (9 L × 41 days;
Autor:
Maryam Ardalan, Kuljeet Singh, Da Kang, Gagan Singh-Mallah, Jian Guan, Christopher D. McMahon, Carina Mallard
Background and Purpose: Cyclic glycine-proline (cGP) regulates the function of insulin-like growth factor-1 (IGF-1), which is essential for post-natal brain development and adult cognitive function. We evaluated the efficacy of maternally administere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e47c27de3b49f4a042ff9359ff1ee48a
https://doi.org/10.22541/au.160524384.43903215/v1
https://doi.org/10.22541/au.160524384.43903215/v1
Autor:
Ferenc Jeanplong, Shelley J Falconer, Jenny M Oldham, Mark Thomas, Tarra S Gray, Alex Hennebry, Kenneth G Matthews, Frederick C Kemp, Ketan Patel, Carole Berry, Gina Nicholas, Christopher D McMahon
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e81713 (2013)
Myostatin plays a fundamental role in regulating the size of skeletal muscles. To date, only a single myostatin gene and no splice variants have been identified in mammals. Here we describe the splicing of a cryptic intron that removes the coding seq
Externí odkaz:
https://doaj.org/article/4f9ba57ff9a6476e82269b6e474e45fe
Autor:
Marianne S. Elston, John V. Conaglen, Kenneth G. Matthews, Sarina Lim, Christopher D. McMahon, Gerard Devlin
Publikováno v:
Heart, Lung and Circulation. 27:693-701
Background Myostatin inhibits the development of skeletal muscle and regulates the proliferation of skeletal muscle fibroblasts. However, the role of myostatin in regulating cardiac muscle or myofibroblasts, specifically in acute myocardial infarctio
Publikováno v:
Frontiers in Bioscience. 23:1848-1863
Understanding the role of the PI3K/AKT pathway in regulating basic antler stem cell parameters and angiogenesis may provide an insight into the mechanisms underlying mammalian appendage development. The present study took multiple approaches in vitro
Autor:
Miranda D. Grounds, Jenny M. Oldham, Philip W. Sheard, Jeremy Bracegirdle, Tea Shavlakadze, Carole Berry, Alexander Hennebry, Marta L. Fiorotto, Heather K. Smith, Gina Nicholas, Christopher D. McMahon, Ferenc Jeanplong, Shelley J. Falconer, Trevor Watson, Monica Senna-Salerno, Kenneth G. Matthews
Publikováno v:
Journal of Endocrinology. 234:187-200
Insulin-like growth factors (IGFs) and myostatin have opposing roles in regulating the growth and size of skeletal muscle, with IGF1 stimulating, and myostatin inhibiting, growth. However, it remains unclear whether these proteins have mutually depen