Výsledky vyhledávání - "Christopher D. Marion"

Methotrexate sensitizes drug-resistant metastatic melanoma cells to BRAF V600E inhibitors dabrafenib and encorafenib

Autor: Kevin F Chin, Timothy J. Yen, Vikram Bhattacharjee, Kayleigh C. Ross, Christopher D. Marion, Daehwan Kim

Publikováno v: Oncotarget

Acquired resistance of metastatic melanoma (MM) tumors to BRAF V600E inhibitors (BRAFi’s) is commonplace in the clinic. Habitual relapse of patients contributes to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd2252f90992a4a01ae9fb438b6084c5
https://doi.org/10.18632/oncotarget.24341

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Identification of the Serine Biosynthesis Pathway as a Critical Component of BRAF Inhibitor Resistance of Melanoma, Pancreatic, and Non-Small Cell Lung Cancer Cells

Autor: Kayleigh C. Ross, Vikram Bhattacharjee, Christopher D. Marion, Timothy J. Yen, Andrew J. Andrews

Publikováno v: Molecular cancer therapeutics. 16(8)

Metastatic melanoma cells commonly acquire resistance to BRAF V600E inhibitors (BRAFi). In this study, we identified serine biosynthesis as a critical mechanism of resistance. Proteomic assays revealed differential protein expression of serine biosyn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2948f17d0fbf414b7aa010e2b81826b
https://pubmed.ncbi.nlm.nih.gov/28500236

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Primary Structure Requirements for XenopusNodal-related 3 and a Comparison with Regions Required byXenopus Nodal-related 2

Autor: Carin Ezal, Christopher D. Marion, William C. Smith

Publikováno v: Journal of Biological Chemistry. 275:14124-14131

Transforming growth factor-beta superfamily members play important roles in the early development of animals. Activin and the Xenopus nodal related proteins 1, 2, and 4 induce muscle actin from Xenopus ectodermal explants, whereas the bone morphogene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbd0bb8ccd58a70a833e159219709c65
https://doi.org/10.1074/jbc.275.19.14124

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Direct neural induction and selective inhibition of mesoderm and epidermis inducers by Xnr3

Autor: Christopher D. Marion, Sean George, Kirsten Steele, Carin S. Hansen, William C. Smith

Publikováno v: Development. 124:483-492

During gastrulation in amphibians, secreted factors from Spemann’s organizer act on dorsal ectoderm to induce the central nervous system. A number of secreted factors produced by Spemann’s organizer have recently been identified. The TGFβ family

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a8c8647282266daf6bb66936c7f2090
https://doi.org/10.1242/dev.124.2.483

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Sequence variation in hepatitis C viral isolates

Autor: Shyamala Venkatakrishna, Maurizia Rossana Brunetto, Amy J. Weiner, Tatsuo Miyamura, J. Eric Hall, Michael Houghton, Kevin Crawford, John McHutchinson, Giorgio Maria Saracco, Christopher D. Marion, Ferruccio Bonino, Theo Cuypers, Cindy Christopherson, Kenneth A. Crawford

The single stranded, RNA genome of the hepatitis C (HCV) virus was characterized after approximately a decade of research in the field of non-A, non-B hepatitis (NANBH) (1, reviewed in Refs. 2 and 3). Since 1987, three genomes encoding the 3010-3011

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e49cf5dd9b23cc2b03ff724f1935cbb0
http://hdl.handle.net/11568/18648

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