Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Christopher D. Makinson"'
Autor:
Zhenrui Liao, Kevin C. Gonzalez, Deborah M. Li, Catalina M. Yang, Donald Holder, Natalie E. McClain, Guofeng Zhang, Stephen W. Evans, Mariya Chavarha, Jane Simko, Christopher D. Makinson, Michael Z. Lin, Attila Losonczy, Adrian Negrean
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Fast electrical signaling in dendrites is central to neural computations that support adaptive behaviors. Conventional techniques lack temporal and spatial resolution and the ability to track underlying membrane potential dynamics present ac
Externí odkaz:
https://doaj.org/article/1530b5838c934189b0b0e531262ffc58
Autor:
Sasa Teng, Fenghua Zhen, Li Wang, Jose Canovas Schalchli, Jane Simko, Xinyue Chen, Hao Jin, Christopher D. Makinson, Yueqing Peng
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
In this study, Teng et al. identify a population of glutamatergic neurons in the ventrolateral medulla that control Non-Rapid Eye Movement (NREM) sleep in mice. They uncover an excitatory brainstem-hypothalamic circuit that controls wake-sleep transi
Externí odkaz:
https://doaj.org/article/339bd7c718ad439e9b90dab2bfa2bea5
Autor:
Sophie Colombo, Haritha P. Reddy, Sabrina Petri, Damian J. Williams, Boris Shalomov, Ryan S. Dhindsa, Sahar Gelfman, Daniel Krizay, Amal K. Bera, Mu Yang, Yueqing Peng, Christopher D. Makinson, Michael J. Boland, Wayne N. Frankel, David B. Goldstein, Nathan Dascal
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
De novo mutations in GNB1, encoding the Gβ1 subunit of G proteins, cause a neurodevelopmental disorder with global developmental delay and epilepsy, GNB1 encephalopathy. Here, we show that mice carrying a pathogenic mutation, K78R, recapitulate aspe
Externí odkaz:
https://doaj.org/article/dac698f6f6cf4d51b12011c167d1b0e2
Autor:
Anna V. Elleman, Gabrielle Devienne, Christopher D. Makinson, Allison L. Haynes, John R. Huguenard, J. Du Bois
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Photocaged molecules have advantages in terms of temporal and spatial control compared to conventional pharmacological compounds. The authors present a synthetic saxitoxin derivative affixed to a photocleavable group for precise modulation of Na chan
Externí odkaz:
https://doaj.org/article/bf380589f814439eb42a94b2247df74e
Autor:
Anna V. Elleman, Gabrielle Devienne, Christopher D. Makinson, Allison L. Haynes, John R. Huguenard, J. Du Bois
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/449049f0a23341bca426eafa669d5b54
Publikováno v:
Neurobiology of Disease, Vol 68, Iss , Pp 16-25 (2014)
SCN1A mutations are the main cause of the epilepsy disorders Dravet syndrome (DS) and genetic epilepsy with febrile seizures plus (GEFS+). Mutations that reduce the activity of the mouse Scn8a gene, in contrast, are found to confer seizure resistance
Externí odkaz:
https://doaj.org/article/0975c33e03394cf5b32da8c07f8940cb
Autor:
Steve Horvath, Aaron Gordon, Jimena Andersen, John R. Huguenard, Xinshu Xiao, Jin-Young Park, Christopher D. Makinson, Sergiu P. Pașca, Daniel H. Geschwind, Se-Jin Yoon, Stephen Tran, Alfredo M. Valencia
Publikováno v:
Nature neuroscience
Human stem-cell-derived models provide the promise of accelerating our understanding of brain disorders, but not knowing whether they possess the ability to mature beyond mid- to late-fetal stages potentially limits their utility. We leveraged a dire
Autor:
Stacey B. Dutton, Christopher D. Makinson, Ligia A. Papale, Anupama Shankar, Bindu Balakrishnan, Kazu Nakazawa, Andrew Escayg
Publikováno v:
Neurobiology of Disease, Vol 49, Iss , Pp 211-220 (2013)
Voltage-gated sodium channels (VGSCs) are essential for the generation and propagation of action potentials in electrically excitable cells. Dominant mutations in SCN1A, which encodes the Nav1.1 VGSC α-subunit, underlie several forms of epilepsy, in
Externí odkaz:
https://doaj.org/article/e3564bacdea645b9927d1238050f6227
Autor:
J. Du Bois, Gabrielle Devienne, Christopher D. Makinson, Anna V. Elleman, Allison L. Haynes, John R. Huguenard
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Here we report the pharmacologic blockade of voltage-gated sodium ion channels (NaVs) by a synthetic saxitoxin derivative affixed to a photocleavable protecting group. We demonstrate that a functionalized saxitoxin (STX-eac) enables exquisite spatiot
Autor:
Christopher D. Makinson, Sergiu P. Paşca, Jimena Andersen, Wu Wei, Nicholas Thom, John R. Huguenard, Georgia Panagiotakos, Jonathan A. Bernstein, Fikri Birey, Kimberly R. Cordes Metzler, Nancy A. O'Rourke, Nina Huber, H. Christina Fan, Saiful Islam, Joachim Hallmayer, Lars M. Steinmetz
Publikováno v:
Nature. 545:54-59
The development of the nervous system involves a coordinated succession of events including the migration of GABAergic (γ-aminobutyric-acid-releasing) neurons from ventral to dorsal forebrain and their integration into cortical circuits. However, th