Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Christopher D. Kenny"'
Autor:
Todd D. Williams, Nina Balthasar, Jia Yu, Toshiro Kishi, Elizabeth Edelstein, Vinsee Tang, Lauryn M. Christiansen, Chen-Yu Zhang, Robert A. McGovern, Kathleen G. Mountjoy, Brian Choi, Joel K. Elmquist, Louise Torp Dalgaard, Charlotte E. Lee, Carl J. Aschkenasi, Bradford B. Lowell, Manuel A. R. Ferreira, Olivier Boss, Hisayuki Funahashi, Christopher D. Kenny
Publikováno v:
Cell. 123(3):493-505
Activation of melanocortin-4-receptors (MC4Rs) reduces body fat stores by decreasing food intake and increasing energy expenditure. MC4Rs are expressed in multiple CNS sites, any number of which could mediate these effects. To identify the functional
Autor:
Joel K. Elmquist, Robert A. McGovern, Shun M. Liu, Roberto Coppari, Abigail E. Pullen, Streamson C. Chua, Charlotte E. Lee, Bradford B. Lowell, Thomas Ludwig, Masumi Ichinose, Christopher D. Kenny, Vinsee Tang
Publikováno v:
Cell Metabolism. 1:63-72
SummaryLeptin is required for normal energy and glucose homeostasis. The hypothalamic arcuate nucleus (ARH) has been proposed as an important site of leptin action. To assess the physiological significance of leptin signaling in the ARH, we used mice
Autor:
Nina Balthasar, Bradford B. Lowell, Christopher D. Kenny, Charlotte E. Lee, Roberto Coppari, Robert A. McGovern, Joel K. Elmquist, Streamson C. Chua, Julie E. McMinn, Shun M. Liu, Vinsee Tang
Publikováno v:
Neuron. 42:983-991
Neuroanatomical and electrophysiological studies have shown that hypothalamic POMC neurons are targets of the adipostatic hormone leptin. However, the physiological relevance of leptin signaling in these neurons has not yet been directly tested. Here
Autor:
Lauryn M. Christiansen, Joel K. Elmquist, Michael A. Cowley, Vinsee Tang, Christopher D. Kenny, Harveen Dhillon, Charlotte E. Lee, Roberto Coppari, Elisabeth A. Edelstein, Jeffrey M. Zigman, Streamson C. Chua, Robert A. McGovern, Ryan D. White, Bradford B. Lowell, Nina Balthasar, Chianping Ye
Publikováno v:
Neuron. 49(2)
SummaryLeptin, an adipocyte-derived hormone, acts directly on the brain to control food intake and energy expenditure. An important question is the identity of first-order neurons initiating leptin's anti-obesity effects. A widely held view is that m