Výsledky vyhledávání - "Christopher D. Houle"

K-ras Mutations in Lung Tumors and Tumors from Other Organs are Consistent with a Common Mechanism of Ethylene Oxide Tumorigenesis in the B6C3F1 Mouse

Autor: Christopher D. Houle, Hue-Hua L. Hong, Robert C. Sills, Thai-Vu T. Ton

Publikováno v: Toxicologic Pathology. 35:81-85

Ethylene oxide is a multisite carcinogen in rodents and classified as a human carcinogen by the National Toxicology Program. In 2-year mouse studies, ethylene oxide (EO) induced lung, Harderian gland (HG), and uterine neoplasms. We evaluated represen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b5a387d59e05e7bf9afd592bed67278
https://doi.org/10.1080/01926230601063839

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Cardiovascular Involvement in 8 Dogs withBlastomyces dermatitidisInfection

Autor: Chad Schmiedt, Heidi Kellum, AIfred M. Legendre, Rebecca E. Gompf, Janice M. Bright, Christopher D. Houle, Melissa Schutten, Rebecca Stepien

Publikováno v: Journal of Veterinary Internal Medicine. 20:1351-1354

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::60f68192685bb8e6528f09a9f67c32d3
https://doi.org/10.1111/j.1939-1676.2006.tb00750.x

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Frequent p53 and H-ras Mutations in Benzene- and Ethylene Oxide-Induced Mammary Gland Carcinomas from B6C3F1 Mice

Autor: Robert C. Sills, Thai-Vu T. Ton, Natasha P. Clayton, Hue-Hua L. Hong, Christopher D. Houle, James Huff

Publikováno v: Toxicologic Pathology. 34:752-762

Benzene and ethylene oxide are multisite carcinogens in rodents and classified as human carcinogens by the National Toxicology Program. In 2-year mouse studies, both chemicals induced mammary carcinomas. We examined spontaneous, benzene-, and ethylen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e63e624e6d471a4ff66e42dcebbf867
https://doi.org/10.1080/01926230600935912

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Loss of Expression and Altered Localization of KAI1 and CD9 Protein Are Associated with Epithelial Ovarian Cancer Progression

Autor: Barbara J. Davis, J. Carl Barrett, Julie F. Foley, Cynthia A. Afshari, Xiao-Yu Ding, Christopher D. Houle

Publikováno v: Gynecologic Oncology. 86:69-78

Objective. Impairment of cell adhesion plays a vital role in tumor progression. E- and N-cadherin, CD9, and KAI1 are all adhesion molecules that have been implicated in the progression of several different tumor types. To help explain the potential r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf80ca04b76e9e021b0f219bf0761e02
https://doi.org/10.1006/gyno.2002.6729

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Protective effect of pregnancy for development of uterine leiomyoma

Autor: Barbara J. Davis, J. Carl Barrett, Cheryl L. Walker, Kimberley Cesen-Cummings, Donna D. Baird, Christopher D. Houle

Publikováno v: Carcinogenesis. 22:2049-2052

Many factors that can modulate the risk of developing uterine leiomyoma have been identified, including parity. Epidemiological data on decreased risk of developing this disease has been subject to different interpretations regarding whether pregnanc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9f8cd181e17d062cca56fecd61fe67f
https://doi.org/10.1093/carcin/22.12.2049

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Application of visualization tools to the analysis of histopathological data enhances biological insight and interpretation

Autor: Patrick Hurban, Gary A. Boorman, K. L. Phillips, David E. Malarkey, Christopher D. Houle, Pamela E. Blackshear, Alexandra N. Heinloth, Edward K. Lobenhofer

Publikováno v: Toxicologic pathology. 34(7)

Gene expression profiling, metabolomic screens, and other high-dimensional methods have become an integral part of many biological investigations. To facilitate interpretation of these data, it is important to have detailed phenotypic data—includin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba4442d2ce5ddf4f0aea1a11a4c2ca55
https://pubmed.ncbi.nlm.nih.gov/17178692

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Spontaneous and irradiation-induced tumor susceptibility in BRCA2 germline mutant mice and cooperative effects with a p53 germline mutation

Autor: Kimberly A. McAllister, Roger W. Wiseman, L. Michelle Bennett, Barbara J. Davis, Jason Malphurs, William Gersch, Laura Wharey, Toni Ward, Christopher D. Houle, Laura J. Betz, N. Keith Collins, John C. Seely

Publikováno v: Toxicologic pathology. 34(2)

Mutations in both p53 and BRCA2 are commonly seen together in human tumors suggesting that the loss of both genes enhances tumor development. To elucidate this interaction in an animal model, mice lacking the carboxy terminal domain of Brca2 were cro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::629213d34c79a743bd6d12ca9b891df4
https://pubmed.ncbi.nlm.nih.gov/16546942

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