Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Christopher D. Guzman"'
Autor:
Phillip A. Sharp, Florian I. Schmidt, Sensen Zhang, Randall Jeffrey Platt, Feng Zhang, Lupeng Ye, Murat Gunel, Matthew B. Dong, Sidi Chen, Ryan D. Chow, Youssef Errami, Paul A. Renauer, Guangchuan Wang, Michael A. Q. Martinez, Mark W. Youngblood, Christopher D. Guzman, Kaya Bilguvar
Publikováno v:
Nature neuroscience
PMC
PMC
A causative understanding of genetic factors that regulate glioblastoma pathogenesis is of central importance. Here we developed an adeno-associated virus-mediated, autochthonous genetic CRISPR screen in glioblastoma. Stereotaxic delivery of a virus
Autor:
Stanley Z. Lam, Yaying Du, Xiaoyun Dai, Christopher D. Guzman, Xiaoyu Zhou, Sidi Chen, Jonathan J. Park, Donald R. Lannin, Guangchuan Wang, Hyunu Ray Kim, Lupeng Ye, Jingjia J. Zhou, Matthew B. Dong, Roy S. Herbst, Paul A. Renauer, Ryan D. Chow, Lvyun Zhu, Krista Y. Chen, Youssef Errami, Johanna Shen
Publikováno v:
Cell
CD8 T cells play essential roles in anti-tumor immune responses. Here, we performed genome-scale CRISPR screens in CD8 T cells directly under cancer immunotherapy settings, and identified regulators of tumor infiltration and degranulation. The in viv
Autor:
Xiaoyun Dai, Lupeng Ye, Matthew B. Dong, Guangchuan Wang, Phillip A. Sharp, Sidi Chen, Christopher D. Guzman, Randall Jeffrey Platt, Ryan D. Chow, Feng Zhang
Publikováno v:
Science Advances
Science Advances, 4 (2)
Science Advances, 4 (2)
Cancer genomics consortia have charted the landscapes of numerous human cancers. Whereas somemutations were found in classical oncogenes and tumor suppressors, others have not yet been functionally studied in vivo. To date, a comprehensive assessment
Autor:
Kelley Anderson, George M. Church, Noah D. Taylor, Srivatsan Raman, Christopher D. Guzman, Jameson K. Rogers
Publikováno v:
Nucleic Acids Research
Characterization and standardization of inducible transcriptional regulators has transformed how scientists approach biology by allowing precise and tunable control of gene expression. Despite their utility, only a handful of well-characterized regul
Autor:
Xiaoyun Dai, Randall Jeffrey Platt, Phillip A. Sharp, Feng Zhang, Guangchuan Wang, Ryan D. Chow, Christopher D. Guzman, Sidi Chen, Lupeng Ye, Matthew B. Dong
High-resolution, high-throughput direct in vivo screening of functional genetic factors in native tissues has long been challenging. Adeno-associated viruses (AAV) are powerful carriers of transgenes and have been shown to mediate efficient genome ed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::599366020b2dac190c473390cf0ed7dc
https://doi.org/10.1101/153643
https://doi.org/10.1101/153643
Autor:
Randall Jeffrey Platt, Paul A. Renauer, Florian I. Schmidt, Sensen Zhang, Ryan D. Chow, Fan Zhang, Sidi Chen, Youssef Errami, Murat Gunel, Kaya Bilguvar, Lupeng Ye, Matthew B. Dong, Mark W. Youngblood, Christopher D. Guzman, Phillip A. Sharp, Guangchuan Wang, Michael A. Q. Martinez
Glioblastoma (GBM) is one of the deadliest cancers, with limited effective treatments and single-digit five-year survival1-7. A causative understanding of genetic factors that regulate GBM formation is of central importance8-19. However, a global, qu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4675b17ac523505b06de03e8f1efe3ea
Autor:
Jonathan L. Braff, John Aach, Norbert Perrimon, Dmitry Ter-Ovanesyan, Benjamin E. Housden, Samira Kiani, Daniel J. Wiegand, Christopher D. Guzman, Shuailiang Lin, Jonathan Scheiman, James J. Collins, Eswar Prasad Ramachandran Iyer, Noah Davidsohn, Alejandro Chavez, Ron Weiss, George M. Church, Benjamin W. Pruitt, Suhani Vora, Marcelle Tuttle
Publikováno v:
Nature methods
The RNA-guided nuclease Cas9 can be reengineered as a programmable transcription factor. However, modest levels of gene activation have limited potential applications. We describe an improved transcriptional regulator obtained through the rational de
Autor:
John Aach, Marcelle Tuttle, Benjamin W. Pruitt, Christopher D. Guzman, Daniel J. Wiegand, James J. Collins, Jonathan L. Braff, Suhani Vora, Samira Kiani, George M. Church, Noah Davidsohn, Jonathan Scheiman, Eswar Prasad Ramachandran Iyer, Alejandro Chavez, Ron Weiss, Dmitry Ter-Ovanesyan
The RNA-guided bacterial nuclease Cas9 can be reengineered as a programmable transcription factor by a series of changes to the Cas9 protein in addition to the fusion of a transcriptional activation domain (AD). However, the modest levels of gene act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b342c6ffa1672d722f7eba65570c1048