Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Christopher D. Fjell"'
Autor:
Olga M. Pena, David G. Hancock, Ngan H. Lyle, Adam Linder, James A. Russell, Jianguo Xia, Christopher D. Fjell, John H. Boyd, Robert E.W. Hancock
Publikováno v:
EBioMedicine, Vol 1, Iss 1, Pp 64-71 (2014)
Background: Sepsis involves aberrant immune responses to infection, but the exact nature of this immune dysfunction remains poorly defined. Bacterial endotoxins like lipopolysaccharide (LPS) are potent inducers of inflammation, which has been associa
Externí odkaz:
https://doaj.org/article/1c734797dbc24577918cab5ecd96cdb8
Autor:
Ann M Czyzewski, Håvard Jenssen, Christopher D Fjell, Matt Waldbrook, Nathaniel P Chongsiriwatana, Eddie Yuen, Robert E W Hancock, Annelise E Barron
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0135961 (2016)
Bacterial resistance to conventional antibiotics is a global threat that has spurred the development of antimicrobial peptides (AMPs) and their mimetics as novel anti-infective agents. While the bioavailability of AMPs is often reduced due to proteas
Externí odkaz:
https://doaj.org/article/7da259ce7ab44bdbb031cb95e1ea74c9
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e79207 (2013)
Inflammatory response during sepsis is incompletely understood due to small sample sizes and variable timing of measurements following the onset of symptoms. The vasopressin in septic shock trial (VASST) compared the addition of vasopressin to norepi
Externí odkaz:
https://doaj.org/article/96860154056e4d5b85083e95d096dea2
Autor:
Taka-aki Nakada, Simone A. Thair, Mark M. Wurfel, Mihai Cirstea, Christopher D. Fjell, John H. Boyd, James A. Russell, Elena Topchiy, Catherine Wang, Keith R. Walley
Publikováno v:
Journal of Innate Immunity. 8:57-66
During septic shock, tumor necrosis factor alpha (TNFa) is an early response gene and induces a plethora of genes and signaling pathways. To identify robust signals in genes reliably upregulated by TNFa, we first measured microarray gene expression i
Autor:
Wilkinson, Taka-aki Nakada, Emiri Nakada, Simone A. Thair, John H. Boyd, Keith R. Walley, James A. Russell, Christopher D. Fjell, Melissa K. McConechy, Aguirre-Hernández R
Publikováno v:
Journal of Innate Immunity. 7:545-553
Background: Genetic variations contribute to septic shock mortality. To discover a novel locus, we performed in vitro genome-wide association studies (GWAS) and further tested the result in a cohort of septic shock patients. Methods: Two in vitro GWA
Autor:
Jianguo Xia, Ngan H. Lyle, John H. Boyd, Adam Linder, David G. Hancock, James A. Russell, Christopher D. Fjell, Olga M. Pena, Robert E. W. Hancock
Publikováno v:
EBioMedicine
EBioMedicine, Vol 1, Iss 1, Pp 64-71 (2014)
EBioMedicine, Vol 1, Iss 1, Pp 64-71 (2014)
Background Sepsis involves aberrant immune responses to infection, but the exact nature of this immune dysfunction remains poorly defined. Bacterial endotoxins like lipopolysaccharide (LPS) are potent inducers of inflammation, which has been associat
Publikováno v:
Applied and Environmental Microbiology. 80:4911-4919
Pseudomonas putida is a Gram-negative soil bacterium which is well-known for its versatile lifestyle, controlled by a large repertoire of transcriptional regulators. Besides one- and two-component regulatory systems, the genome of P. putida reveals 1
Autor:
Hector R. Wong, Christopher J. Lindsell, Ville Pettilä, Nuala J. Meyer, Simone A. Thair, Sari Karlsson, James A. Russell, Christopher D. Fjell, John H. Boyd, Esko Ruokonen, Michael G. S. Shashaty, Jason D. Christie, Kimberly W. Hart, Patrick Lahni, Keith R. Walley
Publikováno v:
Critical Care Medicine. 42:781-789
Clinical trials in septic shock continue to fail due, in part, to inequitable and sometimes unknown distribution of baseline mortality risk between study arms. Investigators advocate that interventional trials in septic shock require effective outcom
Autor:
Karin Sävman, Anitha Thomas, Robert E. W. Hancock, Christopher D. Fjell, Edie Dullaghan, Hayde Bolouri, Carina Mallard, Henrik Hagberg, C. Joakim Ek, Kelly L. Brown, Wei Wang, Norbert Maurer
Publikováno v:
Annals of Neurology. 75:395-410
Objective There is currently no pharmacological treatment that provides protection against brain injury in neonates. It is known that activation of an innate immune response is a key, contributing factor in perinatal brain injury; therefore, the neur
Autor:
Olga M. Pena, Jianguo Xia, Robert E. W. Hancock, Christopher D. Fjell, Matthew L. Mayer, David S. Wishart
Publikováno v:
Nucleic Acids Research
The widespread applications of various 'omics' technologies in biomedical research together with the emergence of public data repositories have resulted in a plethora of data sets for almost any given physiological state or disease condition. Properl