Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Christopher D. Dupont"'
Autor:
Christopher D. Dupont, Ingrid L. Scully, Ross M. Zimnisky, Brinda Monian, Christina P. Rossitto, Ellen B. O'Connell, Kathrin U. Jansen, Annaliesa S. Anderson, J. Christopher Love
Publikováno v:
mSphere, Vol 3, Iss 4 (2018)
ABSTRACT Staphylococcus aureus causes severe disease in humans for which no licensed vaccine exists. A novel S. aureus vaccine (SA4Ag) is in development, targeting the capsular polysaccharides (CPs) and two virulence-associated surface proteins. Vacc
Externí odkaz:
https://doaj.org/article/ec62c241bbc54b0ca93bc9305e01660a
Autor:
Bin Jia, Lisa K McNeil, Christopher D Dupont, Konstantinos Tsioris, Rachel M Barry, Ingrid L Scully, Adebola O Ogunniyi, Christopher Gonzalez, Michael W Pride, Todd M Gierahn, Paul A Liberator, Kathrin U Jansen, J Christopher Love
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0183738 (2017)
The efficacy of protein-conjugated pneumococcal polysaccharide vaccines has been well characterized for children. The level of protection conferred by unconjugated polysaccharide vaccines remains less clear, particularly for elderly individuals who h
Externí odkaz:
https://doaj.org/article/f9a232275d3844819f11312d25da5b7f
Autor:
Gerald Steven Falchook, Erminia Massarelli, Corey Whalen, Ted Ashburn, Hatem Soliman, Anna Spreafico, Taofeek K. Owonikoko, Robert Wesolowski, Patrick A. Ott, Christopher D. Dupont, John M. Goldberg, Christos Fountzilas, Laura Chow, Igor Puzanov, Julia Auer, Tooba Cheema, Adrienne Yanez, Meredith McKean, Jong Chul Park
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
BackgroundONCR-177 is a recombinant oncolytic herpes simplex virus (oHSV) that retains γ34.5 and is engineered to express five immunomodulatory transgenes (IL-12, FLT3LG ECD, CCL4 and anti-PD-1 and anti-CTLA-4 antibodies) for the intratumoral treatm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a9f459335a7ed5ab83054a624f1bc0c
https://doaj.org/article/7759d1776c924bda80633ee24777f559
https://doaj.org/article/7759d1776c924bda80633ee24777f559
Autor:
Christopher D Dupont, David A Christian, Elizabeth M Selleck, Marion Pepper, Michael Leney-Greene, Gretchen Harms Pritchard, Anita A Koshy, Sagie Wagage, Morgan A Reuter, L David Sibley, Michael R Betts, Christopher A Hunter
Publikováno v:
PLoS Pathogens, Vol 10, Iss 4, p e1004047 (2014)
During infection with the intracellular parasite Toxoplasma gondii, the presentation of parasite-derived antigens to CD4+ and CD8+ T cells is essential for long-term resistance to this pathogen. Fundamental questions remain regarding the roles of pha
Externí odkaz:
https://doaj.org/article/2977843c3cf144dca58b9f44dc6e611a
Autor:
Christina P. Rossitto, J. Christopher Love, Ellen B. O’Connell, Brinda Monian, Kathrin U. Jansen, Ingrid L. Scully, Christopher D. Dupont, Annaliesa S. Anderson, Ross M. Zimnisky
Publikováno v:
mSphere, Vol 3, Iss 4, p e00217-18 (2018)
mSphere, Vol 3, Iss 4 (2018)
mSphere
mSphere, Vol 3, Iss 4 (2018)
mSphere
Staphylococcus aureus causes severe disease in humans for which no licensed vaccine exists. A novel vaccine is in development that targets multiple elements of the bacteria since single-component vaccines have not shown efficacy to date. How these mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f607146f1dddb93b28706ebde52b5d7
https://doaj.org/article/1a6beba17be64d34a00b485e84859d89
https://doaj.org/article/1a6beba17be64d34a00b485e84859d89
Autor:
Dhan Chand, Benjamin Morin, Jennifer Buell, Ekaterina Breous-Nystrom, Jeremy D. Waight, Jedd D. Wolchok, Taha Merghoub, Elise Drouin, Nicholas S. Wilson, Christopher Clarke, Marc Van Dijk, Christopher D. Dupont, Cornelia Anne Mundt, David Savitsky, Andrea Schuster, Mark Findeis, Dennis J. Underwood, Benjamin Duckless, Mariana Manrique, Rebecca Ward, Gerd Ritter, Randi Gombos, Ana M. Martín González, Robert Stein, Jean Marie Cuillerot, Hao Tang, David Schaer
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0191926 (2018)
PLoS ONE
PLoS ONE
CTLA-4 and CD28 exemplify a co-inhibitory and co-stimulatory signaling axis that dynamically sculpts the interaction of antigen-specific T cells with antigen-presenting cells. Anti-CTLA-4 antibodies enhance tumor-specific immunity through a variety o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3531cae0cd1ba02aea8a8ea663edeca
http://europepmc.org/articles/PMC5884502?pdf=render
http://europepmc.org/articles/PMC5884502?pdf=render
Autor:
Xiang-Ping Yang, Golnaz Vahedi, Kiyoshi Hirahara, Masao Tanaka, Arlene H. Sharpe, Hayato Takahashi, Loise M. Francisco, John J. O'Shea, Arian Laurence, Giuseppe Sciumè, Christopher A. Hunter, Hong-Wei Sun, Yuka Kanno, Christopher D. Dupont, Qian Chen, Kamran Ghoreschi, Aisling O’Hara Hall
Publikováno v:
Immunity. 36:1017-1030
Summary Interleukin-27 (IL-27) is a key immunosuppressive cytokine that counters T helper 17 (Th17) cell-mediated pathology. To identify mechanisms by which IL-27 might exert its immunosuppressive effect, we analyzed genes in T cells rapidly induced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fea74932d89c52ebb9f89c5afe92bd22
https://doi.org/10.1016/j.immuni.2012.03.024
https://doi.org/10.1016/j.immuni.2012.03.024
Autor:
Edward Wang, Breelyn A. Wilky, Jennifer Buell, E. Dow, David Savitsky, Hagop Youssoufian, Ana M. Martín González, Olga Shebanova, W. Ortuzar, R.B. Stein, Christopher D. Dupont, S. Coulter, J. Wang, Joyce F. Liu, Kathleen N. Moore, C. Drescher, David M. O'Malley, Vivek Subbiah, G. Yuan
Publikováno v:
Annals of Oncology. 29:viii412-viii413
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21d5c341f89b47f3579b5c1785c608f6
https://doi.org/10.1093/annonc/mdy288.031
https://doi.org/10.1093/annonc/mdy288.031
Autor:
S. Hu, David Savitsky, Olga Shebanova, M. Carini, E. Dow, T. Meniawy, Christopher D. Dupont, M. Lim, R.B. Stein, Ana M. Martín González, Charlotte Lemech, W. Ortuzar, Jennifer Buell, Hagop Youssoufian, Jermaine Coward
Publikováno v:
Annals of Oncology. 29:viii417
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cea661360c51f49d54a28a4d845043f7
https://doi.org/10.1093/annonc/mdy288.041
https://doi.org/10.1093/annonc/mdy288.041
Autor:
Christopher A. Hunter, Beth Gregg, Elia D. Tait, Kimberly A. Jordan, Christopher D. Dupont, Tajie H. Harris, Florence Dzierszinski, Emma H. Wilson, David S. Roos, Marion Pepper
Publikováno v:
The Journal of Immunology. 185:1502-1512
The Toxoplasma gondii population consists of multiple strains, defined by genotype and virulence. Previous studies have established that protective immunity to this organism is mediated by IL-12, which drives T cells to produce IFN-γ. Paradoxically,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a294036910ec3e841f29eeaff09433e
https://doi.org/10.4049/jimmunol.0903450
https://doi.org/10.4049/jimmunol.0903450