Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Christopher D. Delaney"'
Autor:
Lu Yang, Anthony K. N. Chan, Kazuya Miyashita, Christopher D. Delaney, Xi Wang, Hongzhi Li, Sheela Pangeni Pokharel, Sandra Li, Mingli Li, Xiaobao Xu, Wei Lu, Qiao Liu, Nicole Mattson, Kevin Yining Chen, Jinhui Wang, Yate-Ching Yuan, David Horne, Steven T. Rosen, Yadira Soto-Feliciano, Zhaohui Feng, Takayuki Hoshii, Gang Xiao, Markus Müschen, Jianjun Chen, Scott A. Armstrong, Chun-Wei Chen
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Identifying functional domains and genetic regulatory mechanisms is essential for developing new therapies. Here the authors present sc-Tiling, single-cell high-density CRISPR tiling screening for functional domain characterization.
Externí odkaz:
https://doaj.org/article/ddb7b59f991343969e3fce23606cbf5c
Autor:
Sumaya Abusrewil, Jason L. Brown, Christopher D. Delaney, Mark C. Butcher, Ryan Kean, Dalia Gamal, J. Alun Scott, William McLean, Gordon Ramage
Publikováno v:
Microorganisms, Vol 8, Iss 12, p 1988 (2020)
There is a growing realization that endodontic infections are often polymicrobial, and may contain Candida spp. Despite this understanding, the development of new endodontic irrigants and models of pathogenesis remains limited to mono-species biofilm
Externí odkaz:
https://doaj.org/article/0aaf6db45d67459782151c73a26ba388
Autor:
Zhaohui Feng, Yate-Ching Yuan, Nicole Mattson, Mingli Li, Kevin Yining Chen, Steven T. Rosen, Xi Wang, Markus Müschen, Anthony K. N. Chan, Xiaobao Xu, Qiao Liu, Jinhui Wang, Wei Lu, Hongzhi Li, Kazuya Miyashita, Christopher D. Delaney, Chun-Wei Chen, Lu Yang, Jianjun Chen, Yadira M. Soto-Feliciano, Scott A. Armstrong, Sheela Pangeni Pokharel, David Horne, Gang Xiao, Takayuki Hoshii, Sandra Li
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Identification of novel functional domains and characterization of detailed regulatory mechanisms in cancer-driving genes is critical for advanced cancer therapy. To date, CRISPR gene editing has primarily been applied to defining the role of individ
Autor:
Wen-Han Chang, Anthony K. N. Chan, Qiao Liu, Scott A. Armstrong, Kazuya Miyashita, Chun-Wei David Chen, Christopher D. Delaney, Lu Yang, Sheela Pangeni Pokharel
Publikováno v:
Blood. 134:530-530
Leukemic patients with MLL gene rearrangements (MLL-r) suffer from unfavorable prognosis and lack of effective targeted therapy. Recent studies suggest that MLL-r leukemias are frequently associated with epigenetic dysregulations; therefore, targetin
Autor:
Alex Kentsis, Zhaohui Feng, Christopher D. Delaney, Takayuki Hoshii, Paolo Cifani, Scott W. Lowe, Richard Koche, Scott A. Armstrong, Chun-Wei Chen, Chun-Hao Huang
Summary MLL/SET methyltransferases catalyze methylation of histone 3 lysine 4 and play critical roles in development and cancer. We assessed MLL/SET proteins and found that SETD1A is required for survival of acute myeloid leukemia (AML) cells. Mutage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac77461d534bd4f07a92118d7135c49a
https://europepmc.org/articles/PMC6052445/
https://europepmc.org/articles/PMC6052445/
Autor:
Haiming Xu, Kathrin M. Bernt, John G. Doench, James E. Bradner, Scott A. Armstrong, Rowena Eng, Xi Wang, Christopher D. Delaney, William C. Hahn, Nan Zhu, Aniruddha J. Deshpande, Chun-Wei Chen, David E. Root, Scott H. Chu, Richard Koche, Amit U. Sinha, Jun Qi
Publikováno v:
Nature Medicine. 21:335-343
Rearrangements of MLL (encoding lysine-specific methyltransferase 2A and officially known as KMT2A; herein referred to as MLL to denote the gene associated with mixed-lineage leukemia) generate MLL fusion proteins that bind DNA and drive leukemogenic
Autor:
Johannes Zuber, Aniruddha J. Deshpande, Meghan E. Eisold, Chun-Wei Chen, Takayuki Hoshii, Tej K. Pandita, Scott A. Armstrong, Haiming Xu, Yujun George Zheng, Daria G. Valerio, Monica Cusan, Chun-Hao Huang, Amaia Lujambio, Scott W. Lowe, Christopher D. Delaney
Chromatin-based mechanisms offer therapeutic targets in acute myeloid leukemia (AML) that are of great current interest. In this study, we conducted an RNAi-based screen to identify druggable chromatin regulator–based targets in leukemias marked by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae68b24b29600795f9a6565327e092f3
https://europepmc.org/articles/PMC5501293/
https://europepmc.org/articles/PMC5501293/
Autor:
Scott A. Armstrong, Sheela Pangeni Pokharel, Anthony K. N. Chan, Kazuya Miyashita, Sandra Li, Chun-Wei Chen, Hongzhi Li, Yadira M. Soto-Feliciano, Christopher D. Delaney, Yanchun Guo, Xi Wang, Lu Yang, Wen-Han Chang, Takayuki Hoshii
Publikováno v:
Blood. 132:179-179
Leukemias containing Mixed Lineage Leukemiagene rearrangement (MLL-r) account for 5-10% of human acute leukemia cases and are associated with a poor prognosis. The unmet clinical need and the lack of an effective targeted therapy emphasizes the need
Autor:
Scott A. Armstrong, Sheng Cai, Xi Wang, James E. Bradner, Jonathan Chabon, Chun-Hao Huang, Zhaohui Feng, Justin He, Amaya Lujambio Goizueta, Christopher D. Delaney, Takayuki Hoshii, Jun Qi, Richard Koche, Michael Kuehn, Chun-Wei David Chen, S. Haihua Chu, Andrei V. Krivtsov, Daria G. Valerio, Monica Cusan, Yining Kevin Chen, Scott W. Lowe, Haiming Xu
Publikováno v:
Blood. 128:571-571
Mixed Lineage Leukemia gene rearrangements (MLL-r) account for nearly 10% of human acute leukemia cases and are generally associated with poor prognosis. Previous studies have revealed an essential role of the histone H3K79 methyltransferase Disrupto
Autor:
Zhaohui Feng, Robert G. Roeder, Chun-Wei David Chen, Chun-Hao Huang, Tomoyoshi Nakadai, Scott W. Lowe, Christopher D. Delaney, Richard Koche, Paolo Cifani, Alex Kentsis, Scott A. Armstrong, Takayuki Hoshii
Publikováno v:
Blood. 128:434-434
Methylation of Histone Lysine 4 is a known histone modification associated with active gene transcription and it is modified by MLL/SET methyltransferases, including MLL1-5 and SETD1A/B. Here we show that a non-catalytic function of SETD1A is require