Zobrazeno 1 - 10
of 527
pro vyhledávání: '"Christopher D. Buckley"'
Autor:
Georgiana Neag, Jonathan Lewis, Jason D. Turner, Julia E. Manning, Isaac Dean, Melissa Finlay, Gowsihan Poologasundarampillai, Jonathan Woods, Muhammad Arham Sahu, Kabir A. Khan, Jenefa Begum, Helen M. McGettrick, Ilaria Bellantuono, Victoria Heath, Simon W. Jones, Christopher D. Buckley, Roy Bicknell, Amy J. Naylor
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-13 (2024)
Abstract Type-H capillary endothelial cells control bone formation during embryogenesis and postnatal growth but few signalling mechanisms underpinning this influence have been characterised. Here, we identify a highly expressed type-H endothelial ce
Externí odkaz:
https://doaj.org/article/85498a388ee845cc9022af51c103ca92
Autor:
Paramita Baruah, Jennifer L. Marshall, Meriam Nefla, Valentina Pucino, Holly Adams, Jason D. Turner, Sebastian Gilbert, Emily Powell, Georgiana Neag, Peter Monksfield, Richard M. Irving, Adam P. Croft, Ingrid E. Dumitriu, Christopher D. Buckley
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
Background and aimHead and neck paragangliomas (HNPGN) are tumours that carry significant morbidity The role of the stroma in the pathogenesis of HNPGN is not completely understood. This study explores the profile of fibroblasts and macrophages in HN
Externí odkaz:
https://doaj.org/article/2b4ad7c7303a4af8ba2287c86538d1b3
Autor:
Michael T. H. Ng, Rowie Borst, Hamez Gacaferi, Sarah Davidson, Jessica E. Ackerman, Peter A. Johnson, Caio C. Machado, Ian Reekie, Moustafa Attar, Dylan Windell, Mariola Kurowska-Stolarska, Lucy MacDonald, Stefano Alivernini, Micon Garvilles, Kathrin Jansen, Ananya Bhalla, Angela Lee, James Charlesworth, Rajat Chowdhury, Paul Klenerman, Kate Powell, Carl-Philip Hackstein, ICECAP Consortium, Dominic Furniss, Jonathan Rees, Derek Gilroy, Mark Coles, Andrew J. Carr, Stephen N. Sansom, Christopher D. Buckley, Stephanie G. Dakin
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Frozen shoulder is a spontaneously self-resolving chronic inflammatory fibrotic human disease, which distinguishes the condition from most fibrotic diseases that are progressive and irreversible. Using single-cell analysis, we identify pro-i
Externí odkaz:
https://doaj.org/article/0ab5f854810c4af1beacea8e07505eca
Autor:
Jolet Y. Mimpen, Robert Hedley, Anna Ridley, Mathew J. Baldwin, Dylan Windell, Ananya Bhalla, Lorenzo Ramos-Mucci, Christopher D. Buckley, Mark C. Coles, Abtin Alvand, Andrew J. Price, Andrew J. Carr, Stephanie G. Dakin, Sarah J. B. Snelling
Publikováno v:
Arthritis Research & Therapy, Vol 25, Iss 1, Pp 1-15 (2023)
Abstract Objectives Osteoarthritis (OA) is increasingly recognised as a whole joint disease, with an important role for synovium. However, the repertoire of immune cells and fibroblasts that constitute OA synovium remains understudied. This study aim
Externí odkaz:
https://doaj.org/article/ad4812c86da64d16ae2f61590a6143f6
Autor:
Valentina Pucino, Meriam Nefla, Vincent Gauthier, Ghada Alsaleh, Sally A. Clayton, Jennifer Marshall, Andrew Filer, Andy R. Clark, Karim Raza, Christopher D. Buckley
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionThe synovial membrane is the main site of inflammation in rheumatoid arthritis (RA). Here several subsets of fibroblasts and macrophages, with distinct effector functions, have been recently identified. The RA synovium is hypoxic and acid
Externí odkaz:
https://doaj.org/article/cf1c330f4be2412981ed289d70a14e95
Autor:
Saba Nayar, Elena Pontarini, Joana Campos, Onorina Berardicurti, Charlotte G. Smith, Saba Asam, David H. Gardner, Serena Colafrancesco, Davide Lucchesi, Rachel Coleby, Ming-May Chung, Valentina Iannizzotto, Kelly Hunter, Simon J. Bowman, Gianluca Carlesso, Ronald Herbst, Helen M. McGettrick, Jeff Browning, Christopher D. Buckley, Benjamin A. Fisher, Michele Bombardieri, Francesca Barone
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-13 (2022)
The study suggests a link between ICOS-ICOSL signaling and LTa3 induction on T cells. LTa3 subsequently activates fibroblasts in the salivary gland, leading to formation of tertiary lymphoid tissues (TLS).
Externí odkaz:
https://doaj.org/article/d98526377cb948829a419d58788242d6
Autor:
Olalekan Lee Aiyegbusi, Lavinia Ferrante di Ruffano, Ameeta Retzer, Philip N. Newsome, Christopher D. Buckley, Melanie J. Calvert
Publikováno v:
Trials, Vol 23, Iss 1, Pp 1-15 (2022)
Abstract Background Tissue-agnostic drug development provides a paradigm shift in precision medicine and requires innovative trial designs. However, outcome selection for such trials can prove challenging. The objectives of this review were to: (i) I
Externí odkaz:
https://doaj.org/article/d54d62ce295041858e8b838a735a30e1
Autor:
Vincent Gauthier, Maria Kyriazi, Meriam Nefla, Valentina Pucino, Karim Raza, Christopher D. Buckley, Ghada Alsaleh
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Fibroblasts, derived from the embryonic mesenchyme, are a diverse array of cells with roles in development, homeostasis, repair, and disease across tissues. In doing so, fibroblasts maintain micro-environmental homeostasis and create tissue niches by
Externí odkaz:
https://doaj.org/article/37284b22939d444e8a3070cf207582b2
Autor:
Xiangyu Ge, Mojca Frank-Bertoncelj, Kerstin Klein, Amanda McGovern, Tadeja Kuret, Miranda Houtman, Blaž Burja, Raphael Micheroli, Chenfu Shi, Miriam Marks, Andrew Filer, Christopher D. Buckley, Gisela Orozco, Oliver Distler, Andrew P. Morris, Paul Martin, Stephen Eyre, Caroline Ospelt
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-39 (2021)
Abstract Background Genome-wide association studies have reported more than 100 risk loci for rheumatoid arthritis (RA). These loci are shown to be enriched in immune cell-specific enhancers, but the analysis so far has excluded stromal cells, such a
Externí odkaz:
https://doaj.org/article/8cd52096d8e14ee7b73e6f6f9def48f2
Autor:
Fiona Rayner, Amy E. Anderson, Kenneth F. Baker, Christopher D. Buckley, Bernard Dyke, Sally Fenton, Andrew Filer, Carl S. Goodyear, Catharien M. U. Hilkens, Shaun Hiu, Sean Kerrigan, Mariola Kurowska-Stolarska, Fiona Matthews, Iain McInnes, Wan-Fai Ng, Arthur G. Pratt, Jonathan Prichard, Karim Raza, Stefan Siebert, Deborah Stocken, M. Dawn Teare, Stephen Young, John D. Isaacs
Publikováno v:
BMC Rheumatology, Vol 5, Iss 1, Pp 1-10 (2021)
Abstract Background Our knowledge of immune-mediated inflammatory disease (IMID) aetiology and pathogenesis has improved greatly over recent years, however, very little is known of the factors that trigger disease relapses (flares), converting diseas
Externí odkaz:
https://doaj.org/article/7bbdfdc9383c46daab23a559ec6892ed