Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Christopher D. Benjamin"'
Autor:
Aldo A. Rossini, Danny Zipris, Jean Leif, HA Drexhage, Dale L. Greiner, Mohammed Javeed I. Ansari, Jan Rozing, T Hunig, Christopher D. Benjamin, Hideo Yagita, Britte C. Beaudette-Zlatanova, Barbara J. Whalen, Henk Groen, Mohamed H. Sayegh, John P. Mordes
Publikováno v:
American Journal of Transplantation, 6(5), 894-902. Wiley-Blackwell Publishing Ltd
American Journal of Transplantation, 6(5), 894-902. Wiley
American Journal of Transplantation, 6(5), 894-902. Wiley
Costimulatory signals regulate T-cell activation. To investigate the role of costimulation in autoimmunity and transplantation, we studied the BB rat model of type 1 diabetes. Diabetes-prone BB (BBDP) rats spontaneously develop disease when 55-120 da
Autor:
Zhensung Song, Lars Wennberg, Carl G. Groth, Masafumi Goto, Akira Maeda, Olle Korsgren, Christopher D. Benjamin
Publikováno v:
Transplantation. 79:157-164
The authors' aim was to evaluate the efficacy of immunosuppression with monoclonal anti-CD40 ligand antibodies (aCD40L) or nonspecific polyclonal intravenous immunoglobulin (IVIG) in the pig-to-rat islet xenotransplantation model.Fetal porcine islet-
Autor:
Sarah A. Bixler, Christine Ambrose, Yen-Ming Hsu, Jeffrey Thompson, Adrian Whitty, Teresa G. Cachero, Eric S. Day, Christopher D. Benjamin, Mohammad Zafari, Fang Qian, Marc Pelletier, Susan L. Kalled, Leonid Gorelik, Kevin Gilbride, Dahai Gong
Publikováno v:
Journal of Biological Chemistry. 278:33127-33133
BAFF is considered a therapeutic target because dysregulated production of BAFF can induce systemic lupus erythematosus-like phenotype in mice, and elevated levels of BAFF are associated with disease severity in systemic lupus erythematosus and rheum
Autor:
Christopher D. Benjamin, Marina Guillet, Fabien Sebille, Sophie Brouard, Anne Moreau, Jean-Paul Soulillou, Nicolas Degauque, Petzold T
Publikováno v:
Transplantation. 75:169-172
Background. Donor-specific tolerance induction remains an attractive objective that generates much research in the field of transplantation. Unfortunately, most of the protocols available involve pregraft conditioning, making these treatments incompa
Autor:
Robert A. Barrington, Michael C. Carroll, Olga Pozdnyakova, Mohammad Zafari, Christopher D. Benjamin
Publikováno v:
Journal of Experimental Medicine. 196:1189-1200
To dissect the influence of CD21/CD35 and FcγRIIB in antigen retention and humoral memory, we used an adoptive transfer model in which antigen-primed B and T lymphocytes were given to sublethally irradiated wild-type mice or mice deficient in CD21/C
Autor:
Frederick R. Taylor, Christopher D. Benjamin, Cheryl A. Wilson, Yen-Ming Hsu, Kenneth H. Roux, Michael Karpusas, Janine Ferrant, Hess Donna M
Publikováno v:
Molecular Immunology. 39:77-84
The cell surface co-stimulatory protein CD154 (CD40L) is a target for monoclonal antibody (mAb) inhibitors of T-cell mediated immune diseases. This protein, like most other members of the TNF ligand family, forms homotrimeric complexes on the cell su
A novel CD154 monoclonal antibody in acute and chronic rat vascularized cardiac allograft rejection1
Autor:
Christopher D. Benjamin, Alan D. Salama, Xueli Yuan, Mohamed H. Sayegh, A. M. Waaga, Victor M. Dong, Anil Chandraker, Ana J. Coito
Publikováno v:
Transplantation. 73:1736-1742
Background. The CD40-CD154 interaction is critically important in the cell-mediated immune responses. Blockade of this costimulatory pathway has been shown to prevent acute allograft rejection in murine, as well as nonhuman primate models. However, t
Publikováno v:
Pediatric Diabetes. 2:178-183
Islet transplantation in children with autoimmune diabetes will require immunosuppression that has minimal toxicity and side-effects, and overcomes the barrier of autoimmunity. Since antibodies directed against the CD40/154 co-stimulatory pathway may
Autor:
Christopher D. Benjamin, Sarah A. Bixler, Kalpit Vora, Jürg Tschopp, Jeffrey Thompson, Christine Ambrose, Catherine Hession, Martin L. Scott, Jeffrey L. Browning, Irene Sizing, Kathy Strauch, Mohammad Zafari, Pascal Schneider, Fang Qian, Teresa G. Cachero, Colleen Mullen
Publikováno v:
Science. 293:2108-2111
B cell homeostasis has been shown to critically depend on BAFF, the B cell activation factor from the tumor necrosis factor (TNF) family. Although BAFF is already known to bind two receptors, BCMA and TACI, we have identified a third receptor for BAF
Autor:
Kathy Strauch, Janine Ferrant, Yen-Ming Hsu, Michael Karpusas, Jodie Lucci, Christopher D. Benjamin, Frederick R. Taylor, Ellen Garber
Publikováno v:
Structure. 9(4):321-329
Background: CD40 ligand (CD40L or CD154), a member of the tumor necrosis factor (TNF) family, plays a critical role in both humoral and cellular immune responses and has been implicated in biological pathways involving epithelial cells, fibroblasts,