Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Christopher D. McNitt"'
Autor:
Dexing Zeng, Yongkang Gai, Lingyi Sun, Xiaohui Zhang, Christopher D. McNitt, Wei Xing, Vladimir V. Popik, Zhonghan Li, Jun Sun
Publikováno v:
J Org Chem
A novel photo-click-based platform has been developed for rapid screening and affinity optimization of heterobivalent agents. This method allows for the efficient selection of high-affinity dual receptor-targeting agents via streamlining tedious orga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a48ac40b9dabb90dba90669edb66f0ec
https://doi.org/10.1021/acs.joc.9b03122
https://doi.org/10.1021/acs.joc.9b03122
Autor:
Vladimir V. Popik, Xiaofen Ma, Zhanhong Wu, Zibo Li, Hui Wang, Mengzhe Wang, Christopher D. McNitt, Sarah M. Scarry
Publikováno v:
Chemical Communications. 54:7810-7813
Here we report the 18F labeling of a prostate specific membrane antigen (PSMA) ligand via a strain promoted oxa-dibenzocyclooctyne (ODIBO)- or bicyclo[6.1.0]nonyne (BCN)-azide reaction. Although ODIBO reacts with azide 20 fold faster than BCN, in viv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bbfcd0f926a8d37fd95ad9c2766124ce
https://doi.org/10.1039/c8cc03999b
https://doi.org/10.1039/c8cc03999b
Publikováno v:
Journal of the American Chemical Society. 139:14029-14032
Irradiation of cyclopropenone-masked dibenzocyclooctynes with near-infrared pulses from a femtosecond laser triggers photodecarbonylation via nonresonant two- or three-photon excitation. Multiphoton-generated cyclooctynes undergo a SPAAC reaction wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3c702a54ede7d587f9dd96d114eddc9
https://doi.org/10.1021/jacs.7b08472
https://doi.org/10.1021/jacs.7b08472
Autor:
Catherine Tran, Vladimir V. Popik, Robert C. Spitale, Miles Kubota, Sarah Nainar, Christopher D. McNitt
Publikováno v:
Journal of the American Chemical Society. 139:8090-8093
We report the first cellular application of a photoclick SPAAC reagent to label azide-functionalized RNA. 350 nm irradiation of a cyclopropenone caged oxo-dibenzocyclooctyne (photo-ODIBO) biotin yields formation of the SPAAC reactive species, which r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::870bc445999b1340795f137fe8039af3
https://doi.org/10.1021/jacs.7b03121
https://doi.org/10.1021/jacs.7b03121
Autor:
Wilson Luo, Pierangelo Gobbo, Dewey A. Sutton, Christopher D. McNitt, Mark S. Workentin, Vladimir V. Popik
Publikováno v:
Chemistry - A European Journal. 23:1052-1059
In this study, we report the design, synthesis, and characterization of small 3 nm water soluble gold nanoparticles (AuNPs) that feature cyclopropenone-masked strained alkyne moieties capable of undergoing interfacial strain-promoted cycloaddition (i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f2585bb5de045cf4917535cc42e4a1b
https://doi.org/10.1002/chem.201603398
https://doi.org/10.1002/chem.201603398
Autor:
Nataraja Sekhar Yadavalli, Sergiy Minko, Christopher D. McNitt, Vladimir V. Popik, Amine M. Laradji
Publikováno v:
Macromolecules. 49:7625-7631
Herein we report a robust, highly selective, and efficient method to prepare dense poly(ethylene glycol) (PEG) polymer brushes on silicon substrates via solvent-free, catalyst-free, strain-promoted acetylene–azide cycloaddition (SPAAC) reaction. Fi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0566e1c14e7b2b64ff19d28c5a01dcf
https://doi.org/10.1021/acs.macromol.6b01573
https://doi.org/10.1021/acs.macromol.6b01573
Autor:
Mengzhe, Wang, Christopher D, McNitt, Hui, Wang, Xiaofen, Ma, Sarah M, Scarry, Zhanhong, Wu, Vladimir V, Popik, Zibo, Li
Publikováno v:
Chemical communications (Cambridge, England). 54(56)
Here we report the 18F labeling of a prostate specific membrane antigen (PSMA) ligand via a strain promoted oxa-dibenzocyclooctyne (ODIBO)- or bicyclo[6.1.0]nonyne (BCN)-azide reaction. Although ODIBO reacts with azide 20 fold faster than BCN, in viv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::804198c0d76e533536caaefd9445f169
https://pubmed.ncbi.nlm.nih.gov/29946609
https://pubmed.ncbi.nlm.nih.gov/29946609
Autor:
Stuart A. Whitehead, Francisco N. Barrera, Christopher D. McNitt, Vladimir V. Popik, Andrew M. Bayer, Michael D. Best, Shahrina Alam, Daiane S. Alves
Publikováno v:
Bioconjugate Chemistry. 26:1021-1031
For drug delivery purposes, the ability to conveniently attach a targeting moiety that will deliver drugs to cells and then enable controlled release of the active molecule after localization is desirable. Toward this end, we designed and synthesized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abd5eb09d56eb57f55da406fd190845c
https://doi.org/10.1021/acs.bioconjchem.5b00044
https://doi.org/10.1021/acs.bioconjchem.5b00044
Little is known about the reactivity of strain-promoted alkyne–azide cycloaddition (SPAAC) reagents with inorganic azides. We explore the reactions of a variety of popular SPAAC reagents with sodium azide and hydrozoic acid. We find that the reacti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0799dd07b63a9a62505c106c678942ff
https://europepmc.org/articles/PMC5991799/
https://europepmc.org/articles/PMC5991799/
Autor:
Adam J. Carr, Samuel I. Mattern-Schain, Stuart A. Whitehead, Vladimir V. Popik, Shahrina Alam, Christopher D. McNitt, Michael D. Best
Artificial systems for controlled membrane fusion applicable for drug delivery would ideally use triggers that are orthogonal to biology. To apply the strain-promoted alkyne-azide cycloaddition (SPAAC) to drive membrane fusion, oxo-dibenzocyclooctyne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f00254aeadfa7fcef77e59b145ff07ea
https://europepmc.org/articles/PMC5990007/
https://europepmc.org/articles/PMC5990007/