Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Christopher D Wiley"'
Publikováno v:
PLoS ONE, Vol 4, Iss 7, p e6435 (2009)
Identifying the molecular basis of phenotypes that have evolved independently can provide insight into the ways genetic and developmental constraints influence the maintenance of phenotypic diversity. Melanic (darkly pigmented) phenotypes in mammals
Externí odkaz:
https://doaj.org/article/cea99974afb84f61a6a32f1ab0725938
Publikováno v:
PLoS ONE, Vol 3, Iss 10, p e3572 (2008)
Crosses between natural populations of two species of deer mice, Peromyscus maniculatus (BW), and P. polionotus (PO), produce parent-of-origin effects on growth and development. BW females mated to PO males (bwxpo) produce growth-retarded but otherwi
Externí odkaz:
https://doaj.org/article/13bad2d3cce8440690b39c2c9c9bd52c
Autor:
Laurence D. Parnell, Kira S. McCaffrey, Athena W. Brooks, Caren E. Smith, Chao-Qiang Lai, Jacob J. Christensen, Christopher D. Wiley, Jose M. Ordovas
Publikováno v:
Lifestyle Genomics, Vol 16, Iss 1, Pp 124-138 (2023)
Introduction: Rate-limiting enzymes (RLEs) are innate slow points in metabolic pathways, and many function in bio-processes related to nutrient sensing. Many RLEs carry causal mutations relevant to inherited metabolic disorders. Because the activity
Externí odkaz:
https://doaj.org/article/4c723f262a13490c8bb45fdc865b1bbb
Publikováno v:
Biomedicines, Vol 12, Iss 2, p 414 (2024)
Cellular senescence is a complex stress response marked by stable proliferative arrest and the secretion of biologically active molecules collectively known as the senescence-associated secretory phenotype (SASP). Mitochondria-derived reactive oxygen
Externí odkaz:
https://doaj.org/article/6b10dfa27b2a4466913ebea65f588595
Publikováno v:
Cells, Vol 12, Iss 6, p 860 (2023)
Metastasis is a systemic condition and the major challenge among cancer types, as it can lead to multiorgan vulnerability. Recently, attention has been drawn to cellular senescence, a complex stress response condition, as a factor implicated in metas
Externí odkaz:
https://doaj.org/article/992ef65f64904f319a05ddf55b0e5f70
Autor:
Jennifer Lee, Chloe Purello, Sarah L. Booth, Brian Bennett, Christopher D. Wiley, Ron Korstanje
Publikováno v:
GeroScience.
Chow diet is used in the majority of rodent studies and, although assumed to be standardized for dietary source and nutritional contents, it varies widely across commercial formulations. Similarly, current approaches to study aging in rodents involve
Autor:
Judith Campisi, Pierre-Yves Desprez, Chandani Limbad, Christopher D. Wiley, Albert R. Davalos, Marco Demaria, Michael C. Velarde, Jose Flores, Diego A. Diaz, Elijah Jones, Emily Chang, Sena Alptekin, Alexis Valdovinos, Tanya Pulido, Fatouma Alimirah
Supplementary Data supporting the manuscript.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b59381d521715fc65caf131847259a20
https://doi.org/10.1158/0008-5472.22425504
https://doi.org/10.1158/0008-5472.22425504
Autor:
Judith Campisi, Pierre-Yves Desprez, Chandani Limbad, Christopher D. Wiley, Albert R. Davalos, Marco Demaria, Michael C. Velarde, Jose Flores, Diego A. Diaz, Elijah Jones, Emily Chang, Sena Alptekin, Alexis Valdovinos, Tanya Pulido, Fatouma Alimirah
Cellular senescence entails an irreversible growth arrest that evolved in part to prevent cancer. Paradoxically, senescent cells secrete proinflammatory and growth-stimulatory molecules, termed the senescence-associated secretory phenotype (SASP), wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cbf005205af3a3a2da05c292515bfa6
https://doi.org/10.1158/0008-5472.c.6512058.v1
https://doi.org/10.1158/0008-5472.c.6512058.v1
Publikováno v:
Nature Metabolism. 5:355-356
Autor:
Katsuhiko Ishihara, Christopher D. Wiley, Qiuxia Wu, Indra Heckenbach, Ryan Kwok, Herbert G. Kasler, Nathan Basisty, Judith Campisi, Eric Verdin, Jose Alberto Lopez-Dominguez, Issam Ben-Sahra, Shankar S. Iyer, Kaitlyn Vitangcol, Mark S. Schmidt, Charles Brenner, Ik Jung Kim, John C. Newman, Elena Silva, Hoi Shan Wong, Yong-Moon Lee, Abhijit Kale, Eddy Gibbs, Kyong Oh Shin, Morten Scheibye-Knudsen, Angela Oliveira Pisco, Rosalba Perrone, Anthony J. Covarrubias, Stephen R. Quake, Melanie Ott, Rebeccah Riley, Birgit Schilling
Publikováno v:
Nat Metab
Declining tissue nicotinamide adenine dinucleotide (NAD) levels are linked to ageing and its associated diseases. However, the mechanism for this decline is unclear. Here, we show that pro-inflammatory M1-like macrophages, but not naive or M2 macroph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f61511ea586b3cbd91a077842b7bacd
https://europepmc.org/articles/PMC7908681/
https://europepmc.org/articles/PMC7908681/