Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Christopher D Sibley"'
Autor:
Matthew L Workentine, Christopher D Sibley, Bryan Glezerson, Swathi Purighalla, Jens C Norgaard-Gron, Michael D Parkins, Harvey R Rabin, Michael G Surette
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e60225 (2013)
The opportunistic pathogen Pseudomonas aeruginosa chronically infects the lower airways of patients with cystic fibrosis. Throughout the course of infection this organism undergoes adaptations that contribute to its long-term persistence in the airwa
Externí odkaz:
https://doaj.org/article/afd1b3202b55422ab2954edf506f1ea6
Publikováno v:
PLoS Pathogens, Vol 7, Iss 10, p e1002299 (2011)
Pseudomonas aeruginosa is an opportunistic pathogen capable of causing both acute and chronic infections in susceptible hosts. Chronic P. aeruginosa infections are thought to be caused by bacterial biofilms. Biofilms are highly structured, multicellu
Externí odkaz:
https://doaj.org/article/2342147224644849a0c0412849668218
Autor:
Christopher D Sibley, Margot E Grinwis, Tyler R Field, Christina S Eshaghurshan, Monica M Faria, Scot E Dowd, Michael D Parkins, Harvey R Rabin, Michael G Surette
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e22702 (2011)
The microbiome of the respiratory tract, including the nasopharyngeal and oropharyngeal microbiota, is a dynamic community of microorganisms that is highly diverse. The cystic fibrosis (CF) airway microbiome refers to the polymicrobial communities pr
Externí odkaz:
https://doaj.org/article/8f2d2091e9e84cb585bdff9906031cc8
Autor:
Christopher D Sibley, Kangmin Duan, Carrie Fischer, Michael D Parkins, Douglas G Storey, Harvey R Rabin, Michael G Surette
Publikováno v:
PLoS Pathogens, Vol 4, Iss 10, p e1000184 (2008)
A number of human infections are characterized by the presence of more than one bacterial species and are defined as polymicrobial diseases. Methods for the analysis of the complex biological interactions in mixed infections with a large number of mi
Externí odkaz:
https://doaj.org/article/a0980f08195449eab94bbaed47b4c103
Publikováno v:
Trends in Pharmacological Sciences. 43:263-265
Recently, Chen and colleagues reported the development of phosphatase-targeting chimeric molecules (PhosTACs), heterobifunctional small molecules that promote targeted, proximity-induced protein dephosphorylation. This strategy represents an innovati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e919c0d64ac6a0cd85c633dff8a71a6
https://doi.org/10.1016/j.tips.2022.01.005
https://doi.org/10.1016/j.tips.2022.01.005
Autor:
Christopher D. Sibley, Emily A. Morris, Webster L. Santos, Tao Huang, Yugesh Kharel, Anne M. Brown, Kevin R. Lynch, David R. Bevan
Publikováno v:
J Med Chem
The sphingosine-1-phosphate (S1P) signaling pathway is an attractive drug target due to its involvement in immune cell chemotaxis and vascular integrity. The formation of S1P is catalyzed by sphingosine kinase 1 or 2 (SphK1 or SphK2) from sphingosine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb7bc23102e599376de1c2b9c7557805
https://doi.org/10.1021/acs.jmedchem.9b01508
https://doi.org/10.1021/acs.jmedchem.9b01508
Autor:
Christopher D. Sibley, Carla Slebodnick, Eric J. Medici, Laura G. Wonilowicz, Webster L. Santos, Russell G. Fritzemeier, Connor Szwetkowski
Publikováno v:
Organic Letters. 21:8053-8057
A method for the preparation of air stable difluoroboryl acrylamides is reported. In contrast to the ubiquitous organotrifluoroborate salts, difluoroboryl acrylamides are relatively nonpolar and are readily purified by silica chromatography. Difluoro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb61712de681bf9103310c7bc9a0829b
https://doi.org/10.1021/acs.orglett.9b03031
https://doi.org/10.1021/acs.orglett.9b03031
Publikováno v:
SAGE Open Medical Case Reports, Vol 8 (2020)
SAGE Open Medical Case Reports
SAGE Open Medical Case Reports
Tattoo pigment can precipitate numerous inflammatory states, and granulomatous tattoo reactions are a diagnostically challenging form. The skin is the most common site of inflammation, but systemic inflammation can occur. Reactions to black tattoo in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ce0957c34dd74420a9d1989a2edcac7
https://doaj.org/article/12cd4a5937a546479a785ea627d48812
https://doaj.org/article/12cd4a5937a546479a785ea627d48812
Autor:
Alya Heirali, Michael G. Surette, Nicole Acosta, Harvey R. Rabin, Matthew L. Workentine, Michael D. Parkins, Ranjani Somayaji, Christopher D. Sibley
Publikováno v:
Thorax. 73:1016-1025
BackgroundComplex polymicrobial communities infect cystic fibrosis (CF) lower airways. Generally, communities with low diversity, dominated by classical CF pathogens, associate with worsened patient status at sample collection. However, it is not kno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91287e04d7164e0a0dedfac70227f2ee
https://doi.org/10.1136/thoraxjnl-2018-211510
https://doi.org/10.1136/thoraxjnl-2018-211510
Autor:
Andrew G. M. Bulloch, M.S. Farris, Isabelle A. Vallerand, Scott B. Patten, Michele L. Ramien, Christopher D. Sibley, Ryan T. Lewinson
Publikováno v:
British Journal of Dermatology. 178:76-85
Despite many years of clinical use of isotretinoin, a comprehensive review of evidence for isotretinoin therapy in patients with acne is lacking. We searched MEDLINE, Embase, Cochrane Central, relevant web pages and bibliographies for randomized cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::746c58e3066de4a8ee6a21f271584aeb
https://doi.org/10.1111/bjd.15668
https://doi.org/10.1111/bjd.15668