Zobrazeno 1 - 10
of 132
pro vyhledávání: '"Christopher D Scharer"'
Publikováno v:
PLoS Pathogens, Vol 16, Iss 4, p e1008438 (2020)
One of the defining characteristics of the B cell receptor (BCR) is the extensive diversity in the repertoire of immunoglobulin genes that make up the BCR, resulting in broad range of specificity. Gammaherpesviruses are B lymphotropic viruses that es
Externí odkaz:
https://doaj.org/article/09b66100827c472e9c8dcee21a7fcde5
Autor:
Esther Zumaquero, Sara L Stone, Christopher D Scharer, Scott A Jenks, Anoma Nellore, Betty Mousseau, Antonio Rosal-Vela, Davide Botta, John E Bradley, Wojciech Wojciechowski, Travis Ptacek, Maria I Danila, Jeffrey C Edberg, S Louis Bridges Jr, Robert P Kimberly, W Winn Chatham, Trenton R Schoeb, Alexander F Rosenberg, Jeremy M Boss, Ignacio Sanz, Frances E Lund
Publikováno v:
eLife, Vol 8 (2019)
Although B cells expressing the IFNγR or the IFNγ-inducible transcription factor T-bet promote autoimmunity in Systemic Lupus Erythematosus (SLE)-prone mouse models, the role for IFNγ signaling in human antibody responses is unknown. We show that
Externí odkaz:
https://doaj.org/article/fc145a6e8204428a8ea15655113e477f
Autor:
Weirong Chen, So-Hee Hong, Scott A. Jenks, Fabliha A. Anam, Christopher M. Tipton, Matthew C. Woodruff, Jennifer R. Hom, Kevin S. Cashman, Caterina Elisa Faliti, Xiaoqian Wang, Shuya Kyu, Chungwen Wei, Christopher D. Scharer, Tian Mi, Sakeenah Hicks, Louise Hartson, Doan C. Nguyen, Arezou Khosroshahi, Saeyun Lee, Youliang Wang, Regina Bugrovsky, Yusho Ishii, F. Eun-Hyung Lee, Ignacio Sanz
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by multiple autoantibody types, some of which are produced by long-lived plasma cells (LLPC). Active SLE generates increased circulating antibody-secreting cells (ASC)
Externí odkaz:
https://doaj.org/article/32d01e342442483b94987433b744c8c5
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
The germinal center response or reaction (GCR) is a hallmark event of adaptive humoral immunity. Unfolding in the B cell follicles of the secondary lymphoid organs, a GC culminates in the production of high-affinity antibody-secreting plasma cells al
Externí odkaz:
https://doaj.org/article/5e589c15bc734046aa4a472526fd8801
Autor:
Omer Gokcumen, Qihui Zhu, Lubbertus C F Mulder, Rebecca C Iskow, Christian Austermann, Christopher D Scharer, Towfique Raj, Jeremy M Boss, Shamil Sunyaev, Alkes Price, Barbara Stranger, Viviana Simon, Charles Lee
Publikováno v:
PLoS Genetics, Vol 9, Iss 4, p e1003404 (2013)
Ancient population structure shaping contemporary genetic variation has been recently appreciated and has important implications regarding our understanding of the structure of modern human genomes. We identified a ∼36-kb DNA segment in the human g
Externí odkaz:
https://doaj.org/article/e5a221c3e1214f9da489979a98d2f913
Autor:
James R. Rose, Bagdeser Akdogan-Ozdilek, Andrew R. Rahmberg, Michael D. Powell, Sakeenah L. Hicks, Christopher D. Scharer, Jeremy M. Boss
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-19 (2023)
An integrated analysis uncovers transcriptional and epigenetic differences of human circulating memory T cell subsets and identifies unique transcription factor networks associated with memory subset differentiation.
Externí odkaz:
https://doaj.org/article/a067bd43035a480cbc06a1f70910044e
Autor:
Miranda L. Curtiss, Alexander F. Rosenberg, Christopher D. Scharer, Betty Mousseau, Natalia A. Ballesteros Benavides, John E. Bradley, Beatriz León, Chad Steele, Troy D. Randall, Frances E. Lund
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionData from patient cohorts and mouse models of atopic dermatitis, food allergy and asthma strongly support a role for chitinase-3-like-1 protein (CHI3L1) in allergic disease.MethodsTo address whether Chi3l1 also contributes to TH2 response
Externí odkaz:
https://doaj.org/article/cac7025d889a467685c55cbc25d7bc30
Autor:
Zhihong Zuo, Anna K. Kania, Dillon G. Patterson, Sakeenah L. Hicks, Jeffrey Maurer, Mansi Gupta, Jeremy M. Boss, Christopher D. Scharer
Publikováno v:
Heliyon, Vol 9, Iss 6, Pp e17527- (2023)
The transcription factor Interferon regulatory factor 8 (IRF8) is involved in maintaining B cell identity. However, how IRF8 regulates T cell independent B cell responses are not fully characterized. Here, an in vivo CRISPR/Cas9 system was optimized
Externí odkaz:
https://doaj.org/article/e2d535e0932a4c759017e58be7c52fae
Autor:
Miyoung Lee, Delaney K. Geitgey, Jamie A. G. Hamilton, Jeremy M. Boss, Christopher D. Scharer, Jennifer M. Spangle, Karmella A. Haynes, Curtis J. Henry
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
The world’s population with obesity is reaching pandemic levels. If current trends continue, it is predicted that there will be 1.5 billion people with obesity by 2030. This projection is alarming due to the association of obesity with numerous dis
Externí odkaz:
https://doaj.org/article/256b4796d3674787b290beebc2961457
Autor:
Martin A. Rivas, Ceyda Durmaz, Andreas Kloetgen, Cristopher R. Chin, Zhengming Chen, Bhavneet Bhinder, Amnon Koren, Aaron D. Viny, Christopher D. Scharer, Jeremy M. Boss, Olivier Elemento, Christopher E. Mason, Ari M. Melnick
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The cohesin complex plays critical roles in genomic stability and gene expression through effects on 3D architecture. Cohesin core subunit genes are mutated across a wide cross-section of cancers, but not in germinal center (GC) derived lymphomas. In
Externí odkaz:
https://doaj.org/article/d81425a378284c1c898ba5565c38ac34