Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Christopher D Lucas"'
Publikováno v:
Frontiers in Immunology, Vol 5 (2014)
Due to the key role of the lung in efficient transfer of oxygen in exchange for carbon dioxide, a controlled inflammatory response is essential for restoration of tissue homeostasis following airway exposure to bacterial pathogens or environmental to
Externí odkaz:
https://doaj.org/article/65db8512be214345b8f57462971f9d01
Autor:
Ana L Alessandri, Rodger Duffin, Andrew E Leitch, Christopher D Lucas, Tara A Sheldrake, David A Dorward, Nik Hirani, Vanessa Pinho, Lirlândia Pires de Sousa, Mauro M Teixeira, John F Lyons, Christopher Haslett, Adriano G Rossi
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e25683 (2011)
Eosinophils not only defend the body against parasitic infection but are also involved in pathological inflammatory allergic diseases such as asthma, allergic rhinitis and contact dermatitis. Clearance of apoptotic eosinophils by macrophages is a key
Externí odkaz:
https://doaj.org/article/c1a3b7d4cbea493cac69e41a520b8a9c
Autor:
Amanda Croasdell Lucchini, Naomi N. Gachanja, Adriano G. Rossi, David A. Dorward, Christopher D. Lucas
Publikováno v:
Cells, Vol 10, Iss 2, p 339 (2021)
Respiratory diseases are frequently characterised by epithelial injury, airway inflammation, defective tissue repair, and airway remodelling. This may occur in a subacute or chronic context, such as asthma and chronic obstructive pulmonary disease, o
Externí odkaz:
https://doaj.org/article/e3df7c52fb6a4863a9620d8253e6b958
Autor:
Ya-Ting Wang, Alissa J. Trzeciak, Waleska Saitz Rojas, Pedro Saavedra, Yan-Ting Chen, Rachel Chirayil, Jon Iker Etchegaray, Christopher D. Lucas, Daniel J. Puleston, Kayvan R. Keshari, Justin S.A. Perry
Publikováno v:
Wang, Y-T, Trzeciak, A, Saitz Rojas, W, Saavedra, P, Chen, Y-T, Chirayil, R, Etchegaray, J I, Lucas, C D, Puleston, D, Keshari, K R & Perry, J S A 2022, ' Metabolic adaptation supports enhanced macrophage efferocytosis in limited-oxygen environments ', Cell Metabolism . https://doi.org/10.1016/j.cmet.2022.12.005
Apoptotic cell clearance (efferocytosis), a process essential for organismal homeostasis, is performed by phagocytes that inhabit harsh tissue environments, including physiologic hypoxia. Here, we find macrophages, the predominant tissue-resident pha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c593d4d11765ae5621f0e8065f6d1fd
https://www.pure.ed.ac.uk/ws/files/319436586/Wang_Submission.pdf
https://www.pure.ed.ac.uk/ws/files/319436586/Wang_Submission.pdf
Autor:
Pedro H. V. Saavedra, Alissa Trzeciak, Zhaoquan Wang, Waleska Saitz Rojas, Giulia Zago, Melissa D. Docampo, Jacob G. Verter, Marcel R. M. van den Brink, Christopher D. Lucas, Christopher J. Anderson, Alexander Y. Rudensky, Justin S. A. Perry
The phagocytic clearance of dying cells, termed efferocytosis, is essential for both tissue homeostasis and tissue health during cell death-inducing treatments. Failure to efficiently clear dying cells augments the risk of pathological inflammation a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f88d8bbaea31816b390ff1793ac56b0
https://doi.org/10.1101/2022.08.17.504322
https://doi.org/10.1101/2022.08.17.504322
Autor:
Ya-Ting Wang, Alissa Trzeciak, Waleska Saitz Rojas, Pedro Saavedra, Yan-Ting Chen, Rachel Chirayil, Jon Iker Etchegaray, Christopher D. Lucas, Daniel J. Puleston, Kayvan R. Keshari, Justin S. A. Perry
SummaryApoptotic cell clearance (efferocytosis), a process essential for organismal homeostasis, is performed by phagocytes that inhabit a wide range of environments, including physiologic hypoxia. Here, we find macrophages, the predominant tissue-re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66b3abe2ffec01f183d10e0d9ca53b00
https://doi.org/10.1101/2022.08.04.502838
https://doi.org/10.1101/2022.08.04.502838
Autor:
Brian J. McHugh, Jillian Stephen, Calum T. Robb, Sarah Fox, Tiina Kipari, Jennifer A. Cartwright, Christopher Haslett, Rodger Duffin, Christopher D. Lucas, Adriano G. Rossi
Publikováno v:
McHugh, B, Stephen, J, Robb, C, Fox, S, Kipari, T, Cartwright, J, Haslett, C, Duffin, R, Lucas, C D & Rossi, A G 2022, ' Inhibition of cyclin-dependent kinase 9 downregulates cytokine production without detrimentally affecting human monocyte-derived macrophage viability ', Frontiers in Cell and Developmental Biology, vol. 10, 905315 . https://doi.org/10.3389/fcell.2022.905315
Cyclin-dependent kinase (CDK) inhibitor drugs (CDKi), such as R-roscovitine and AT7519, induce neutrophil apoptosisin vitroand enhance the resolution of inflammation in a number ofin vivomodels. This class of compounds are potential novel therapeutic
Autor:
Christopher D. Lucas, Christopher B. Medina, Finnius A. Bruton, David A. Dorward, Michael H. Raymond, Turan Tufan, J. Iker Etchegaray, Brady Barron, Magdalena E. M. Oremek, Sanja Arandjelovic, Emily Farber, Suna Onngut-Gumuscu, Eugene Ke, Moira K. B. Whyte, Adriano G. Rossi, Kodi S. Ravichandran
Publikováno v:
SCIENCE IMMUNOLOGY
Lucas, C D, Medina, C B, Bruton, F, Dorward, D, Raymond, M H, Tufan, T, Etchegaray, J I, Barron, B, Oremek, M, Arandjelovic, S, Farber, E, Onngut-Gumuscu, S, Ke, E, Whyte, M K B, Rossi, A G & Ravichandran, K S 2022, ' Pannexin 1 drives efficient epithelial repair after tissue injury ', Science Immunology, vol. 7, no. 71, eabm4032 . https://doi.org/10.1126/sciimmunol.abm4032
Lucas, C D, Medina, C B, Bruton, F, Dorward, D, Raymond, M H, Tufan, T, Etchegaray, J I, Barron, B, Oremek, M, Arandjelovic, S, Farber, E, Onngut-Gumuscu, S, Ke, E, Whyte, M K B, Rossi, A G & Ravichandran, K S 2022, ' Pannexin 1 drives efficient epithelial repair after tissue injury ', Science Immunology, vol. 7, no. 71, eabm4032 . https://doi.org/10.1126/sciimmunol.abm4032
Epithelial tissues such as lung and skin are exposed to the environment and therefore particularly vulnerable to damage during injury or infection. Rapid repair is therefore essential to restore function and organ homeostasis. Dysregulated epithelial
Publikováno v:
International review of cell and molecular biology. 367
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to the largest global pandemic in living memory, with between 4.5 and 15M deaths globally from coronavirus disease 2019 (COVID-19). This has led to an unparalleled
Autor:
Michael H, Raymond, Andrew J, Davidson, Yi, Shen, Daniel R, Tudor, Christopher D, Lucas, Sho, Morioka, Justin S A, Perry, Julia, Krapivkina, David, Perrais, Linus J, Schumacher, Robert E, Campbell, Will, Wood, Kodi S, Ravichandran
Publikováno v:
Science (New York, N.Y.). 375(6585)
Apoptosis of cells and their subsequent removal through efferocytosis occurs in nearly all tissues during development, homeostasis, and disease. However, it has been difficult to track cell death and subsequent corpse removal in vivo. We developed a