Zobrazeno 1 - 10
of 133
pro vyhledávání: '"Christopher D Lima"'
Autor:
Devanshi Jain, M Rhyan Puno, Cem Meydan, Nathalie Lailler, Christopher E Mason, Christopher D Lima, Kathryn V Anderson, Scott Keeney
Publikováno v:
eLife, Vol 7 (2018)
Mechanisms regulating mammalian meiotic progression are poorly understood. Here we identify mouse YTHDC2 as a critical component. A screen yielded a sterile mutant, ‘ketu’, caused by a Ythdc2 missense mutation. Mutant germ cells enter meiosis but
Externí odkaz:
https://doaj.org/article/08ec398323f14159913426dc55b9377a
Publikováno v:
eLife, Vol 6 (2017)
Nuclear RNA exosomes catalyze a range of RNA processing and decay activities that are coordinated in part by cofactors, including Mpp6, Rrp47, and the Mtr4 RNA helicase. Mpp6 interacts with the nine-subunit exosome core, while Rrp47 stabilizes the ex
Externí odkaz:
https://doaj.org/article/3001c44def614adb99d747f25f8af67f
Autor:
Yuhki Saito, Ben R. Hawley, M. Rhyan Puno, Shreya N. Sarathy, Christopher D. Lima, Samie R. Jaffrey, Robert B. Darnell, Scott Keeney, Devanshi Jain
Publikováno v:
Genes & Development. 36:180-194
Mechanisms regulating meiotic progression in mammals are poorly understood. The N6-methyladenosine (m6A) reader and 3′ → 5′ RNA helicase YTHDC2 switches cells from mitotic to meiotic gene expression programs and is essential for meiotic entry,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa0a85f8cc77c9b57f29c1d63f9b34bd
https://doi.org/10.1101/gad.349190.121
https://doi.org/10.1101/gad.349190.121
Publikováno v:
Proceedings of the National Academy of Sciences. 120
The Ufd1/Npl4/Cdc48 complex is a universal protein segregase that plays key roles in eukaryotic cellular processes. Its functions orchestrating the clearance or removal of polyubiquitylated targets are established; however, prior studies suggest that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eba82f4ee6d1b4a6d03b3efca8d0f9b
https://doi.org/10.1073/pnas.2213703120
https://doi.org/10.1073/pnas.2213703120
Autor:
M Rhyan, Puno, Christopher D, Lima
Publikováno v:
Methods in enzymology. 673
The nuclear RNA exosome collaborates with the MTR4 helicase and RNA adaptor complexes to process, surveil, and degrade RNA. Here we outline methods to characterize RNA translocation and strand displacement by exosome-associated helicases and adaptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9dffee62ce7a1aacf34acaed8c2c2dcc
https://pubmed.ncbi.nlm.nih.gov/35965016
https://pubmed.ncbi.nlm.nih.gov/35965016
Autor:
M. Rhyan Puno, Christopher D. Lima
Publikováno v:
Cell
RNA quality control relies on co-factors and adaptors to identify and prepare substrates for degradation by ribonucleases such as the 3' to 5' ribonucleolytic RNA exosome. Here, we determined cryogenic electron microscopy structures of human nuclear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0b2f8fb29e63fd2027f1cee8f2dba11
https://europepmc.org/articles/PMC9210550/
https://europepmc.org/articles/PMC9210550/
Autor:
Jacqueline Gire O’Rourke, Jaclyn R. Gareau, Joseph Ochaba, Wan Song, Tamás Raskó, David Reverter, John Lee, Alex Mas Monteys, Judit Pallos, Lisa Mee, Malini Vashishtha, Barbara L. Apostol, Thomas Peter Nicholson, Katalin Illes, Ya-Zhen Zhu, Mary Dasso, Gillian P. Bates, Marian Difiglia, Beverly Davidson, Erich E. Wanker, J. Lawrence Marsh, Christopher D. Lima, Joan S. Steffan, Leslie M. Thompson
Publikováno v:
Cell Reports, Vol 4, Iss 2, Pp 362-375 (2013)
A key feature in Huntington disease (HD) is the accumulation of mutant Huntingtin (HTT) protein, which may be regulated by posttranslational modifications. Here, we define the primary sites of SUMO modification in the amino-terminal domain of HTT, sh
Externí odkaz:
https://doaj.org/article/2cae4460f6614c9f87bd7c29ab921075
Autor:
M. Rhyan Puno, Christopher D. Lima
Publikováno v:
Helicase Enzymes Part B ISBN: 9780323997737
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::beeff94f0f4420f5ed06836abed45e19
https://doi.org/10.1016/bs.mie.2022.03.060
https://doi.org/10.1016/bs.mie.2022.03.060
Autor:
Yuhki, Saito, Ben R, Hawley, M Rhyan, Puno, Shreya N, Sarathy, Christopher D, Lima, Samie R, Jaffrey, Robert B, Darnell, Scott, Keeney, Devanshi, Jain
Publikováno v:
Genesdevelopment. 36(3-4)
Mechanisms regulating meiotic progression in mammals are poorly understood. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5227ee7d460bd9c2bbbc54bd9af7ef34
https://pubmed.ncbi.nlm.nih.gov/35058317
https://pubmed.ncbi.nlm.nih.gov/35058317
Publikováno v:
The EMBO Journal
Repair of DNA double‐stranded breaks by homologous recombination (HR) is dependent on DNA end resection and on post‐translational modification of repair factors. In budding yeast, single‐stranded DNA is coated by replication protein A (RPA) fol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c51cbbb6375ad2dee57878a98fabc264
http://europepmc.org/articles/PMC8591536
http://europepmc.org/articles/PMC8591536