Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Christopher D J Sinclair"'
Autor:
Valeria Ricotti, Matthew R B Evans, Christopher D J Sinclair, Jordan W Butler, Deborah A Ridout, Jean-Yves Hogrel, Ahmed Emira, Jasper M Morrow, Mary M Reilly, Michael G Hanna, Robert L Janiczek, Paul M Matthews, Tarek A Yousry, Francesco Muntoni, John S Thornton
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0162542 (2016)
A number of promising experimental therapies for Duchenne muscular dystrophy (DMD) are emerging. Clinical trials currently rely on invasive biopsies or motivation-dependent functional tests to assess outcome. Quantitative muscle magnetic resonance im
Externí odkaz:
https://doaj.org/article/19bd8f41fda140849f988d7494cfbc4e
Autor:
Tracey A Willis, Kieren G Hollingsworth, Anna Coombs, Marie-Louise Sveen, Soren Andersen, Tanya Stojkovic, Michelle Eagle, Anna Mayhew, Paulo Loureiro de Sousa, Liz Dewar, Jasper M Morrow, Christopher D J Sinclair, John S Thornton, Kate Bushby, Hanns Lochmuller, Michael G Hanna, Jean-Yves Hogrel, Pierre G Carlier, John Vissing, Volker Straub
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e90377 (2014)
We conducted a prospective multinational study of muscle pathology using magnetic resonance imaging (MRI) in patients with limb-girdle muscular dystrophy 2I (LGMD2I). Thirty eight adult ambulant LGMD2I patients (19 male; 19 female) with genetically i
Externí odkaz:
https://doaj.org/article/809289b1bcdc4a229f182469ffcb1256
Autor:
Tracey A Willis, Kieren G Hollingsworth, Anna Coombs, Marie-Louise Sveen, Søren Andersen, Tanya Stojkovic, Michelle Eagle, Anna Mayhew, Paulo L de Sousa, Liz Dewar, Jasper M Morrow, Christopher D J Sinclair, John S Thornton, Kate Bushby, Hanns Lochmüller, Michael G Hanna, Jean-Yves Hogrel, Pierre G Carlier, John Vissing, Volker Straub
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e70993 (2013)
Outcome measures for clinical trials in neuromuscular diseases are typically based on physical assessments which are dependent on patient effort, combine the effort of different muscle groups, and may not be sensitive to progression over short trial
Externí odkaz:
https://doaj.org/article/52f1434bf16d451bb2e6f4224e501642
Autor:
Alexander P. Murphy, Jasper Morrow, Julia R. Dahlqvist, Tanya Stojkovic, Tracey A. Willis, Christopher D. J. Sinclair, Stephen Wastling, Tarek Yousry, Michael S. Hanna, Meredith K. James, Anna Mayhew, Michelle Eagle, Laurence E. Lee, Jean‐Yves Hogrel, Pierre G. Carlier, John S. Thornton, John Vissing, Kieren G. Hollingsworth, Volker Straub
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 6, Iss 6, Pp 1033-1045 (2019)
Abstract Objective Limb girdle muscular dystrophy type R9 (LGMD R9) is an autosomal recessive muscle disease for which there is currently no causative treatment. The development of putative therapies requires sensitive outcome measures for clinical t
Externí odkaz:
https://doaj.org/article/8b6e15b896ea41baaac336a6d6cf25b8
Autor:
Pietro Fratta, Andrea Malaspina, Robin Howard, Karin Trimmel, Luca Zampedri, Ahmed Emira, Nikhil Sharma, John S. Thornton, Jasper M. Morrow, Linda Greensmith, Tarek A. Yousry, Katie Sidle, Stephen J. Wastling, Uros Klickovic, Michael G. Hanna, Christopher D. J. Sinclair, Sachit Shah
Publikováno v:
Neurology
ObjectiveTo investigate the use of muscle MRI for the differential diagnosis and as a disease progression biomarker for 2 major forms of motor neuron disorders: spinal bulbar muscular atrophy (SBMA) and amyotrophic lateral sclerosis (ALS).MethodsWe a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c456caa7b3b98b04d07fc8497d3c504d
http://europepmc.org/articles/PMC6745729
http://europepmc.org/articles/PMC6745729
Autor:
Avneesh Chhabra, Lianxin Zhao, John A. Carrino, Eo Trueblood, Saso Koceski, Filip Shteriev, Lionel Lenkinski, Christopher D. J. Sinclair, Gustav Andreisek
Publikováno v:
Radiology Research and Practice, Vol 2013 (2013)
High resolution and high field magnetic resonance neurography (MR neurography, MRN) is shown to have excellent anatomic capability. There have been considerable advances in the technology in the last few years leading to various feasibility studies u
Externí odkaz:
https://doaj.org/article/d08460fb0072420eaeafe617b458d483
Autor:
Giuseppe Lauria, Michael G. Hanna, U Kugathasan, Tarek A. Yousry, Khadijah Owusu-Ansah, Matthew R B Evans, David L.H. Bennett, James M. Polke, Henry Houlden, Thorsten Hornemann, Mary M. Reilly, Emma R. Wilson, Christopher D. J. Sinclair, Saranya Suriyanarayanan, John S. Thornton, Jasper M. Morrow, Raffaella Lombardi, Matilde Laura, Julian Blake
Publikováno v:
Journal of neurology, neurosurgery, and psychiatry. 90(8)
ObjectivesHereditary sensory neuropathy type 1 (HSN1) is a rare, slowly progressive neuropathy causing profound sensory deficits and often severe motor loss. L-serine supplementation is a possible candidate therapy but the lack of responsive outcome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e8379f4321a958391787a5cbc8831e6
https://pubmed.ncbi.nlm.nih.gov/30995999
https://pubmed.ncbi.nlm.nih.gov/30995999
Autor:
Robert L. Janiczek, Sachit Shah, Mary M. Reilly, Christopher D. J. Sinclair, Jasper M. Morrow, John S. Thornton, Michael G. Hanna, Elham Rawah, Matthew R B Evans, Tarek A. Yousry
Publikováno v:
NMR in Biomedicine. 29:1800-1812
Quantifying muscle water T2 (T2 -water) independently of intramuscular fat content is essential in establishing T2 -water as an outcome measure for imminent new therapy trials in neuromuscular diseases. IDEAL-CPMG combines chemical shift fat-water se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57e35859a5300128784aee06e17a1bcc
https://doi.org/10.1002/nbm.3654
https://doi.org/10.1002/nbm.3654
Autor:
Jasper M. Morrow, John S. Thornton, Sarah Finlayson, David Beeson, MJ White, A Fischmann, Stephanie A. Robb, Tarek A. Yousry, Sandeep Jayawant, Jacqueline Palace, Steve Knight, Nicola Carboni, Christopher D. J. Sinclair, Pedro M. Rodríguez Cruz, Ray Norbury, Michal Al-Hajjar
Publikováno v:
Muscle & Nerve. 54:211-219
Introduction In this study we investigated muscle magnetic resonance imaging in congenital myasthenic syndromes (CMS). Methods Twenty-six patients with 9 CMS subtypes and 10 controls were imaged. T1-weighted (T1w) and short-tau inversion recovery (ST
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf85d9cf71516eb8ca7a7228d78100bc
https://doi.org/10.1002/mus.25035
https://doi.org/10.1002/mus.25035
Autor:
Mary M. Reilly, Jasper M. Morrow, Christopher D. J. Sinclair, John S. Thornton, Sachit Shah, Michael P. Lunn, Tarek A. Yousry
Publikováno v:
European Journal of Radiology. 130:109164
Purpose Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a treatable, immune-mediated condition characterised by progressive or relapsing motor and sensory neurological deficits. The diagnosis is based on a combination of clinical,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c57020eab3311c9e71c54e19defee204
https://doi.org/10.1016/j.ejrad.2020.109164
https://doi.org/10.1016/j.ejrad.2020.109164