Zobrazeno 1 - 10 of 18 pro vyhledávání: '"Christopher D Heger"'
1
Akademický článek
A proof-of-concept analysis of carbohydrate-deficient transferrin by imaged capillary isoelectric focusing and in-capillary immunodetection
Autor: Jiaqi Wu, Charles H Haitjema, Christopher D Heger, Annegret Boge
Publikováno v: BioTechniques, Vol 68, Iss 2, Pp 85-90 (2020)
Carbohydrate-deficient transferrin (CDT) is a reliable biomarker for chronic alcohol abuse. We developed a method for CDT analysis by capillary isoelectric focusing, followed by immunodetection directly in the capillary, in an automated fashion and o
Externí odkaz: https://doaj.org/article/1d579584a5b94c37a1a308cf396e28f0
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2
Akademický článek
Phosphorylation provides a negative mode of regulation for the yeast Rab GTPase Sec4p.
Autor: Christopher D Heger, Christiane D Wrann, Ruth N Collins
Publikováno v: PLoS ONE, Vol 6, Iss 9, p e24332 (2011)
The Rab family of Ras-related GTPases are part of a complex signaling circuitry in eukaryotic cells, yet we understand little about the mechanisms that underlie Rab protein participation in such signal transduction networks, or how these networks are
Externí odkaz: https://doaj.org/article/6f6f20a483de47ce890c723dfb46877c
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7
Data from LPA Receptor Heterodimerizes with CD97 to Amplify LPA-Initiated RHO-Dependent Signaling and Invasion in Prostate Cancer Cells
Autor: Kathleen Kelly, Maria Merino, Paul K. Goldsmith, Mark Raffeld, Christopher D. Heger, Juan Juan Yin, Ross Lake, Yvona Ward
CD97, an adhesion-linked G-protein–coupled receptor (GPCR), is induced in multiple epithelial cancer lineages. We address here the signaling properties and the functional significance of CD97 expression in prostate cancer. Our findings show that CD
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::19929f721173bc68efd9bbe8409c83fe
https://doi.org/10.1158/0008-5472.c.6503009.v1
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9
Brightfield Proximity Ligation Assay Reveals Both Canonical and Mixed Transforming Growth Factor-β/Bone Morphogenetic Protein Smad Signaling Complexes in Tissue Sections
Autor: Samuel L. Dengler, Catherine M. Conway, Misako Sato, Binwu Tang, Lalage M. Wakefield, Paul K. Goldsmith, Christopher D. Heger, Kathleen C. Flanders, Stephen M. Hewitt
Publikováno v: Journal of Histochemistry and Cytochemistry
Transforming growth factor-β (TGF-β) is an important regulator of cellular homeostasis and disease pathogenesis. Canonical TGF-β signaling occurs through Smad2/3–Smad4 complexes; however, recent in vitro studies suggest that elevated levels of T
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecf40cd7a99f1b55fbdffab2204a652b
https://doi.org/10.1369/0022155414550163
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10
Phosphorylation of centromeric histone H3 variant regulates chromosome segregation inSaccharomyces cerevisiae
Autor: Lars Boeckmann, John S. Choy, Munira A. Basrai, Yoshimitsu Takahashi, Christopher McAndrew, Anthony R. Dawson, Christopher D. Heger, Timothy J. Waybright, Prashant K. Mishra, Timothy D. Veenstra, May Y. Szeto, Paul K. Goldsmith, Richard Baker, Wei-Chun Au
Publikováno v: Molecular Biology of the Cell
Cse4 is posttranslationally modified in Saccharomyces cerevisiae. Ipl1 contributes to Cse4 phosphorylation in vivo and in vitro. Phosphorylation of Cse4 at centromeres is enhanced in response to nocodazole or reduced cohesion. The results suggest tha
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ffba19ca43e755274d638bd8bb934d0
https://doi.org/10.1091/mbc.e12-12-0893
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