Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Christopher D Benham"'
Autor:
Sara Pritchard, Michael J Jackson, Atsuko Hikima, Lisa Lione, Christopher D Benham, K Ray Chaudhuri, Sarah Rose, Peter Jenner, Mahmoud M Iravani
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0175797 (2017)
Bladder hyperreflexia is a common non-motor feature of Parkinson's disease. We now report on the contractility of the isolated primate detrusor strips devoid of nerve input and show that following MPTP, the amplitude and frequency of spontaneous cont
Externí odkaz:
https://doaj.org/article/c52a377c08d5456daba255145312d234
Publikováno v:
European Journal of Pharmacology. 842:321-328
Diabetic vascular dysfunction is a major complication of diabetes. Methylglyoxal (MGO) is a dicarbonyl metabolite elevated in diabetic plasma that reacts with interstitial molecules to form advanced glycation end products (AGE). We investigated wheth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::151aa92579d8c8db220ee52b6f339fe9
https://doi.org/10.1016/j.ejphar.2018.10.056
https://doi.org/10.1016/j.ejphar.2018.10.056
Autor:
Madhu Goyal, Jonathan A. G. Cox, Gurdyal S. Besra, Bhavani Anagani, Christopher D. Benham, Jatinder P. Bassin, Jagbir Singh, Tummala Rama Krishna Reddy
Publikováno v:
The Cell Surface, Vol 6, Iss, Pp 100041-(2020)
The Cell Surface
The Cell Surface
Highlights • Chalcone 1a inhibits the growth of Mycobacterium bovis BCG (MIC 6.25 µg.ml−1). • Chalcone 1a directly targets InhA.
Objectives The search for new TB drugs has become one of the great challenges for modern medicinal chemistry.
Objectives The search for new TB drugs has become one of the great challenges for modern medicinal chemistry.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bd151125dfaf5b433544d0825fffe78
http://www.sciencedirect.com/science/article/pii/S2468233020300086
http://www.sciencedirect.com/science/article/pii/S2468233020300086
Autor:
Erika Coletto, Sarah Rose, Alex Gant, Christopher D. Benham, K. Ray Chaudhuri, Peter Jenner, Sarah Pritchard, John S. Dolan, Michael J. Jackson, Atsuko Hikima, Mahmoud M. Iravani
Publikováno v:
Coletto, E, Dolan, J S, Pritchard, S, Gant, A, Hikima, A, Jackson, M J, Benham, C D, Ray Chaudhuri, K, Rose, S, Jenner, P & Iravani, M M 2019, ' Contractile dysfunction and nitrergic dysregulation in small intestine of a primate model of Parkinson's disease ', Nature Parkinson's Journal, vol. 5, 31231674 . https://doi.org/10.1038/s41531-019-0081-9
NPJ Parkinson's Disease
npj Parkinson's Disease, Vol 5, Iss 1, Pp 1-12 (2019)
NPJ Parkinson's Disease
npj Parkinson's Disease, Vol 5, Iss 1, Pp 1-12 (2019)
Bowel dysfunction is a common non-motor symptom in Parkinson’s disease (PD). The main contractile neurotransmitter in the GI tract is acetylcholine (ACh), while nitric oxide (NO) causes the relaxation of smooth muscle in addition to modulating ACh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45429ad20718814057e5115ad7785dac
https://doi.org/10.1038/s41531-019-0081-9
https://doi.org/10.1038/s41531-019-0081-9
Publikováno v:
Current Drug Metabolism. 17:359-367
Background: Diabetes mellitus (DM) is a pandemic metabolic disease characterized by a chronically elevated blood glucose concentration (hyperglycemia) due to insulin dysfunction. Approximately 50% of diabetics show diabetes complications by the time
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f0e7debdbd186659746bf08b9cff988
https://doi.org/10.2174/1389200217666151222155216
https://doi.org/10.2174/1389200217666151222155216
Publikováno v:
European Journal of Pharmacology. 888:173441
Endothelial dysfunction is a common complication in diabetes in which endothelium-dependent vasorelaxation is impaired. The aim of this study was to examine the involvement of the TRPV4 ion channel in type 1 diabetic endothelial dysfunction and the p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da0779efb5c56cea25332b014d634960
https://doi.org/10.1016/j.ejphar.2020.173441
https://doi.org/10.1016/j.ejphar.2020.173441
Publikováno v:
Diabetes/metabolism research and reviews. 34(5)
Diabetes is a complex progressive disease characterized by chronic hyperglycaemia and dyslipidaemia associated with endothelial dysfunction. Oxidized LDL (Ox-LDL) is elevated in diabetes and may contribute to endothelial dysfunction. The aim of this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c802ddbe5f966f450ea737b0ad4d598c
https://pubmed.ncbi.nlm.nih.gov/29471582
https://pubmed.ncbi.nlm.nih.gov/29471582
Publikováno v:
Molecular Immunology. 102:227-228
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1a7af60818eb37c27f5645dc4c5bc65
https://doi.org/10.1016/j.molimm.2018.06.244
https://doi.org/10.1016/j.molimm.2018.06.244
Autor:
Max J. Lab, Rolfe Birch, C. Bountra, Daniel Sánchez, Uma Anand, Christopher D. Benham, Praveen Anand, Julia Gorelik, David Klenerman, Yuri E. Korchev
Mechanosensitive ion channels convert external mechanical force into electrical and chemical signals in cells, but their physiological function in different tissues is not clearly understood. One reason for this is that there is as yet no satisfactor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1171bd40f9dc3397d481c7ce806c84c2
https://ora.ox.ac.uk/objects/uuid:56d82e55-1cac-4e9b-9eb8-e441f01c040c
https://ora.ox.ac.uk/objects/uuid:56d82e55-1cac-4e9b-9eb8-e441f01c040c
Autor:
Madhu Goyal, Ute Gerhard, Maryam Hashemian, Bhavani Anagani, Christopher D. Benham, Jatinder P. Bassin
Publikováno v:
Molecules, Vol 21, Iss 8, p 967 (2016)
Molecules; Volume 21; Issue 8; Pages: 967
Molecules
Molecules; Volume 21; Issue 8; Pages: 967
Molecules
A simple synthetic route affording 27%-85% yields of benzo[6,7][1,5]diazocino[2,1-a]isoindol-12(14H)-one ring systems from readily available 3-(2-oxo-2-phenylethyl) isobenzofuran-1(3H)-ones and 2-(aminomethyl)aniline starting materials in toluene and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a4ca0b50252dace291ebefda0a93918
http://www.mdpi.com/1420-3049/21/8/967
http://www.mdpi.com/1420-3049/21/8/967