Zobrazeno 1 - 10
of 129
pro vyhledávání: '"Christopher C.J. Miller"'
Autor:
Andrea Markovinovic, Sandra M. Martín-Guerrero, Gábor M. Mórotz, Shaakir Salam, Patricia Gomez-Suaga, Sebastien Paillusson, Jenny Greig, Younbok Lee, Jacqueline C. Mitchell, Wendy Noble, Christopher C.J. Miller
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-17 (2024)
Abstract Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are clinically linked major neurodegenerative diseases. Notably, TAR DNA-binding protein-43 (TDP43) accumulations are hallmark pathologies of FTD/ALS and mutations in the
Externí odkaz:
https://doaj.org/article/959726ed7de941829423f9bf27ab624c
Autor:
Naomi Hartopp, Dawn H W. Lau, Sandra M. Martin-Guerrero, Andrea Markovinovic, Gábor M. Mórotz, Jenny Greig, Elizabeth B. Glennon, Claire Troakes, Patricia Gomez-Suaga, Wendy Noble, Christopher C.J. Miller
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Signaling between the endoplasmic reticulum (ER) and mitochondria regulates many neuronal functions that are perturbed in amyotrophic lateral sclerosis (ALS) and perturbation to ER-mitochondria signaling is seen in cell and transgenic models of ALS.
Externí odkaz:
https://doaj.org/article/ab769bb8dd764b90914229b46ae9481b
Autor:
Gábor M. Mórotz, Sandra M. Martín-Guerrero, Andrea Markovinovic, Sebastien Paillusson, Matthew R. G. Russell, Pedro M. Pereira Machado, Roland A. Fleck, Wendy Noble, Christopher C.J. Miller
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Signaling between the endoplasmic reticulum (ER) and mitochondria regulates a number of fundamental physiological processes. This signaling involves close physical contacts between the two organelles that are mediated by the VAPB-PTPIP51 ″tethering
Externí odkaz:
https://doaj.org/article/39eaf584213b4fd8b1fbbb27b0353415
Autor:
Dawn H.W. Lau, Sebastien Paillusson, Naomi Hartopp, Huzefa Rupawala, Gábor M. Mórotz, Patricia Gomez-Suaga, Jenny Greig, Claire Troakes, Wendy Noble, Christopher C.J. Miller
Publikováno v:
Neurobiology of Disease, Vol 143, Iss , Pp 105020- (2020)
Signaling between the endoplasmic reticulum (ER) and mitochondria regulates a number of key neuronal functions, many of which are perturbed in Alzheimer's disease. Moreover, damage to ER-mitochondria signaling is seen in cell and transgenic models of
Externí odkaz:
https://doaj.org/article/fcc36096cd214dbfa79e4bc3e131f481
Autor:
Matteo Beretta, Tsung-Ping Su, Aram Revazian, Katrin Streckfuß-Bömeke, Kai B. Betteridge, Maddy Parsons, Christopher C.J. Miller, Katrin Schröder, Vsevolod V. Belousov, Ajay M. Shah, Roland A. Fleck, Chris Molenaar, Anne D. Hafstad, Celio Xc. Santos, James H. Doroshow
Publikováno v:
Beretta, M, Santos, C X, Molenaar, C, Hafstad, A D, Miller, C C, Revazian, A, Betteridge, K, Schröder, K, Streckfuß-Bömeke, K, Doroshow, J H, Fleck, R A, Su, T-P, Belousov, V V, Parsons, M & Shah, A M 2020, ' Nox4 regulates InsP3 receptor-dependent Ca2+ release into mitochondria to promote cell survival ', The EMBO journal, vol. 39, no. 19, e103530 . https://doi.org/10.15252/embj.2019103530, https://doi.org/10.15252/embj.2019103530
Cells subjected to environmental stresses undergo regulated cell death (RCD) when homeostatic programs fail to maintain viability. A major mechanism of RCD is the excessive calcium loading of mitochondria and consequent triggering of the mitochondria
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2428414e153146144d20d3bed459da8f
https://kclpure.kcl.ac.uk/en/publications/b1dadedb-a236-4e62-98b9-f52f75dffab6
https://kclpure.kcl.ac.uk/en/publications/b1dadedb-a236-4e62-98b9-f52f75dffab6
Autor:
Nadine Muschalik, Dawn H. W. Lau, Jenny Greig, Gábor M. Mórotz, Elizabeth B. Glennon, Francesca Mattedi, Alessio Vagnoni, Wendy Noble, Nishita Bhembre, Christopher C.J. Miller
Publikováno v:
Mórotz, G M, Glennon, E B, Greig, J, Lau, D H W, Bhembre, N, Mattedi, F, Muschalik, N, Noble, W, Vagnoni, A & Miller, C C J 2019, ' Kinesin light chain-1 serine-460 phosphorylation is altered in Alzheimer's disease and regulates axonal transport and processing of the amyloid precursor protein ', Acta Neuropathologica Communications, vol. 7, no. 1, 200 . https://doi.org/10.1186/s40478-019-0857-5
Acta Neuropathologica Communications
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-13 (2019)
Acta Neuropathologica Communications
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-13 (2019)
Damage to axonal transport is an early pathogenic event in Alzheimer’s disease. The amyloid precursor protein (APP) is a key axonal transport cargo since disruption to APP transport promotes amyloidogenic processing of APP. Moreover, altered APP pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28c59c7dcaad7bf991f2fddb1941fd4a
https://kclpure.kcl.ac.uk/ws/files/148224846/Kinesin_light_chain_1_serine_460_VAGNONI_Publishedonline5December2019_GOLD_VoR_CC_BY_.pdf
https://kclpure.kcl.ac.uk/ws/files/148224846/Kinesin_light_chain_1_serine_460_VAGNONI_Publishedonline5December2019_GOLD_VoR_CC_BY_.pdf
Autor:
Christopher C.J. Miller, Sebastien Paillusson, Daniel Little, Patricia Gomez-Suaga, Wendy Noble, Radu Stoica, Diane P. Hanger, Michael J. Devine, Paul Gissen
Publikováno v:
Paillusson, S, Gomez Suaga, P, Stoica, R, Little, D, Gissen, P, Devine, M J, Noble, W, Hanger, D P & Miller, C C J 2017, ' α-Synuclein binds to the ER–mitochondria tethering protein VAPB to disrupt Ca 2+ homeostasis and mitochondrial ATP production ', Acta Neuropathologica, vol. 134, pp. 129–149 . https://doi.org/10.1007/s00401-017-1704-z
α-Synuclein is strongly linked to Parkinson’s disease but the molecular targets for its toxicity are not fully clear. However, many neuronal functions damaged in Parkinson’s disease are regulated by signalling between the endoplasmic reticulum (
Publikováno v:
Biophysical Journal. 120:82a
Autor:
Claire Troakes, Gábor M. Mórotz, Dawn H. W. Lau, Sebastien Paillusson, Naomi Hartopp, Patricia Gomez-Suaga, Jenny Greig, Christopher C.J. Miller, Wendy Noble, Huzefa Rupawala
Publikováno v:
Neurobiology of Disease
Lau, D H W, Paillusson, S, Hartopp, N, Rupawala, H, Mórotz, G M, Gomez-Suaga, P, Greig, J, Troakes, C, Noble, W & Miller, C C J 2020, ' Disruption of endoplasmic reticulum-mitochondria tethering proteins in post-mortem Alzheimer's disease brain ', Neurobiology of Disease, vol. 143, NBD-20-191R1, pp. 1-25 . https://doi.org/10.1016/j.nbd.2020.105020
Neurobiology of Disease, Vol 143, Iss, Pp 105020-(2020)
Lau, D H W, Paillusson, S, Hartopp, N, Rupawala, H, Mórotz, G M, Gomez-Suaga, P, Greig, J, Troakes, C, Noble, W & Miller, C C J 2020, ' Disruption of endoplasmic reticulum-mitochondria tethering proteins in post-mortem Alzheimer's disease brain ', Neurobiology of Disease, vol. 143, NBD-20-191R1, pp. 1-25 . https://doi.org/10.1016/j.nbd.2020.105020
Neurobiology of Disease, Vol 143, Iss, Pp 105020-(2020)
Signaling between the endoplasmic reticulum (ER) and mitochondria regulates a number of key neuronal functions, many of which are perturbed in Alzheimer's disease. Moreover, damage to ER-mitochondria signaling is seen in cell and transgenic models of
Autor:
Yu Wai Chen, Ka Ming Vincent Tam, Ho Yin Edwin Chan, Wan Ning Vanessa Chow, Christopher C.J. Miller, Jacky Chi Ki Ngo, Wen Li, Kwok-Fai Lau
Publikováno v:
Biochemical Journal
Phosphorylation of FE65 Ser610 by serum- and glucocorticoid-induced kinase 1 (SGK1) attenuates amyloid precursor protein (APP) processing via regulation of FE65–APP interaction.
Alzheimer's disease (AD) is a fatal neurodegenerative disease aff
Alzheimer's disease (AD) is a fatal neurodegenerative disease aff