Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Christopher C. Valley"'
Autor:
Diane S. Lidke, M. Edward Medof, Christopher C. Valley, Ajay Sammeta, Elliot Pohlmann, Wasim Hussain, Michael G. Strainic
Publikováno v:
FASEB J
How receptor tyrosine kinase (RTK) growth signaling is controlled physiologically is incompletely understood. We have previously provided evidence that the survival and mitotic activities of vascular endothelial cell growth factor receptor-2 (VEGFR2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e35530503694de346cb6511cae44c5d
https://doi.org/10.1096/fj.201900677r
https://doi.org/10.1096/fj.201900677r
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0123941 (2015)
Fluorescence superresolution (SR) microscopy, or fluorescence nanoscopy, provides nanometer scale detail of cellular structures and allows for imaging of biological processes at the molecular level. Specific SR imaging methods, such as localization-b
Externí odkaz:
https://doaj.org/article/84669deb6a4a40a9859d35fb30bb6414
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1859:1398-1416
The challenge of crystallizing single-pass plasma membrane receptors has remained an obstacle to understanding the structural mechanisms that connect extracellular ligand binding to cytosolic activation. For example, the complex interplay between rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd70baef25814250216841f4ac9f0096
https://doi.org/10.1016/j.bbamem.2017.01.016
https://doi.org/10.1016/j.bbamem.2017.01.016
Autor:
Anthony R. Braun, Andrew K. Lewis, Christine B. Karim, Stephen L. Peery, Benjamin E. Brummel, Jonathan N. Sachs, Christopher C. Valley
Publikováno v:
Journal of Molecular Biology. 428:4843-4855
Death receptor 5 (DR5) is an apoptosis-inducing member of the tumor necrosis factor receptor superfamily, whose activity has been linked to membrane cholesterol content. Upon ligand binding, DR5 forms large clusters within the plasma membrane that ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a5b74098e1fb249e0641e7f4fbe2d63
https://doi.org/10.1016/j.jmb.2016.10.001
https://doi.org/10.1016/j.jmb.2016.10.001
Autor:
Toine ten Broeke, Christopher C. Valley, Keith A. Lidke, Gestur Vidarsson, Jeanette H. W. Leusen, Michael J. Wester, Samantha L. Schwartz, Diane S. Lidke, Gittan L. A. Blezer, Arianne M. Brandsma
Publikováno v:
Science signaling, 11(540):eaaq0891. American Association for the Advancement of Science
Sci Signal
Sci Signal
Fc receptors (FcRs) are an important bridge between the innate and adaptive immune system. Fc gamma receptor I (FcγRI; CD64), the high-affinity receptor for immunoglobulin G (IgG), plays roles in inflammation, autoimmune responses, and immunotherapy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3208a98f23b1fb024c0d2c3efd9672f3
https://pure.amc.nl/en/publications/mechanisms-of-insideout-signaling-of-the-highaffinity-igg-receptor-fcri(05da9665-9ffd-4964-990f-461d5778cebf).html
https://pure.amc.nl/en/publications/mechanisms-of-insideout-signaling-of-the-highaffinity-igg-receptor-fcri(05da9665-9ffd-4964-990f-461d5778cebf).html
Autor:
Mara P. Steinkamp, Alexey I. Chizhik, Diane S. Lidke, William S. Hlavacek, Narain Karedla, Keith A. Lidke, Christopher C. Valley, Bridget S. Wilson, Donna J. Arndt-Jovin
Publikováno v:
Molecular Biology of the Cell
Epidermal growth factor receptor kinase mutations drive oncogenesis, but the molecular mechanism of pathological signal initiation is poorly understood. Using high-resolution microscopy methods, the authors reveal that these kinase mutations induce s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::217df7bc5a2acd8b68feacc36abebcef
https://doi.org/10.1091/mbc.e15-05-0269
https://doi.org/10.1091/mbc.e15-05-0269
Autor:
Mark A. Lemmon, Nicholas J. Bessman, Kathryn M. Ferguson, Christopher C. Valley, Emanuel Salazar-Cavazos, Diane S. Lidke, Jason O. Moore, Daniel M. Freed, Daniel J. Leahy, Patrick O. Byrne, Anatoly Kiyatkin
Epidermal growth factor receptor (EGFR) regulates many crucial cellular programs, with seven different activating ligands shaping cell signaling in distinct ways. Using crystallography and other approaches, we show how the EGFR ligands epiregulin (ER
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04bee0c7189ae253708e4bd9dbb49778
https://europepmc.org/articles/PMC5650921/
https://europepmc.org/articles/PMC5650921/
Autor:
Alessandro Cembran, Christopher C. Valley, Jonathan N. Sachs, Andrew K. Lewis, Nicholas P. Labello, Jason D. Perlmutter, Jiali Gao
Publikováno v:
Journal of Biological Chemistry. 287:34979-34991
Of the 20 amino acids, the precise function of methionine (Met) remains among the least well understood. To establish a determining characteristic of methionine that fundamentally differentiates it from purely hydrophobic residues, we have used in vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f6536b817ace101dc3c79657dbc4001
https://doi.org/10.1074/jbc.m112.374504
https://doi.org/10.1074/jbc.m112.374504
Publikováno v:
Biochemistry. 51:6545-6555
The widely accepted model for tumor necrosis factor 1 (TNFR1) signaling is that ligand binding causes receptor trimerization, which triggers a reorganization of cytosolic domains and thus initiates intracellular signaling. This model of stoichiometri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c49a24310821f495d871a623036af9bd
https://doi.org/10.1021/bi3006626
https://doi.org/10.1021/bi3006626
Autor:
Christopher C. Valley, Charles J. Yeo, Benjamin E. Leiby, Eric Londin, Agnieska K. Witkiewicz, Jordan M. Winter, David W. Rittenhouse, Joseph A. Cozzitorto, Myriam Gorospe, Isidore Rigoutsos, Matthew C. Weber, Richard A. Burkhart, Jonathan N. Sachs, Jonathan R. Brody, Danielle M. Pineda
Publikováno v:
Cancer Biology & Therapy. 13:946-955
Apoptosis is one of the core signaling pathways disrupted in pancreatic ductal adenocarcinoma (PDA). Death receptor 5 (DR5) is a member of the tumor necrosis factor (TNF)-receptor superfamily that is expressed in cancer cells. Binding of TNF-related
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63cf7c41b99e66166c90b0937e8c6bca
https://doi.org/10.4161/cbt.20952
https://doi.org/10.4161/cbt.20952