Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Christopher C. Toner"'
Autor:
Adina T. Michael-Titus, K Connelly, Daniel P. McLaughlin, Robin Whelpton, Christopher C. Toner, S Bains, Jonathan A. Stamford
Publikováno v:
British Journal of Anaesthesia. 86:550-554
Release of excitatory amino acids and dopamine plays a central role in neuronal damage after cerebral ischaemia. In the present study, we used an in vitro model of ischaemia to investigate the effects of sevoflurane on dopamine, glutamate and asparta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dec958db9bd66b7112efa5a0baec5802
https://doi.org/10.1093/bja/86.4.550
https://doi.org/10.1093/bja/86.4.550
Autor:
Daniel P. McLaughlin, Emma Hisgrove, Philip C. Street, Christopher C. Toner, Jonathan A. Stamford, Kusum S. Mathews, E.Lindsey Bezzina, Laila H. Ziabari
Publikováno v:
Journal of Neuroscience Methods. 102:43-51
2,3,5-Triphenyltetrazolium chloride (TTC), a marker of mitochondrial enzyme activity, is widely used to assess the effects of cerebral ischaemia in vivo. In the present study, we characterised its utility as a simple rapid macrohistological measure o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adbd37d9f33d8b460e108a43a37f4c0b
https://doi.org/10.1016/s0165-0270(00)00277-6
https://doi.org/10.1016/s0165-0270(00)00277-6
Publikováno v:
Brain Research Bulletin. 48:395-399
Release of neurotransmitters, including dopamine (DA), plays a central role in neuronal death during cerebral ischaemia. We investigated the effects of changes in energy demand and supply on DA release in cerebral ischaemia in vitro. Rat striatal sli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f10c75ae5c21092512d75091becbff7
https://doi.org/10.1016/s0361-9230(99)00016-7
https://doi.org/10.1016/s0361-9230(99)00016-7
Publikováno v:
Baillière's Clinical Anaesthesiology. 10:515-533
Summary It is widely accepted by anaesthetists that depression of cerebral metabolism is the principal means of anaesthetic neuroprotection. However, the available literature provides little support for this hypothesis. First, the differing susceptib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc30fc86dd80d7a34a08ceeca811ce98
https://doi.org/10.1016/s0950-3501(96)80032-8
https://doi.org/10.1016/s0950-3501(96)80032-8
Publikováno v:
Journal of Neuroscience Methods. 67:133-140
Dopamine (DA) is released in large quantities during ischaemia and may be neurotoxic. For instance, reduction of DA release is associated with a better histological outcome following experimental stroke. In the present study, we report the measuremen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4da6ed56466073795c3a516990cb66b9
https://doi.org/10.1016/0165-0270(96)00030-1
https://doi.org/10.1016/0165-0270(96)00030-1
Autor:
Graham Cooper, Christopher C. Toner, David P. de Bono, Malcolm J. Underwood, R S More, A Coumbe, Philip Reynolds
Publikováno v:
Cardiovascular Research. 29:422-427
Objective: The aim was to quantify the effect of intraluminally applied tissue-type plasminogen activator (tPA) on the fibrinolytic activity of experimental vein grafts and assess the effect of pretreatment of the vein on early platelet and thrombus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::450e3c22452edbf13b805544fa5a6a46
https://doi.org/10.1016/s0008-6363(96)88601-9
https://doi.org/10.1016/s0008-6363(96)88601-9
Publikováno v:
Baillière's Clinical Anaesthesiology. 8:441-460
Summary Four new non-depolarizing drugs offer advantages in different clinical situations. Pipecuronium and doxacurium are long-acting compounds with a relatively slow onset and a variable duration of action. Their main advantage is a lack of cardiov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f871323292d67c7802b814d049eed87f
https://doi.org/10.1016/s0950-3501(05)80101-1
https://doi.org/10.1016/s0950-3501(05)80101-1
Autor:
Christopher C. Toner, Karen L. Blatchford, Jonathan A. Stamford, Andrew J Milne, Daniel P. McLaughlin
Publikováno v:
Brain research. 958(2)
Previous studies using a rat brain slice model of cerebral 'ischaemia' (hypoxia and hypoglycaemia) have suggested that volatile anaesthetics may have cerebroprotective potential. In this study, we tested the cerebroprotective profile of four volatile
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4d50a14ce30d4483d6cbe8b4398395c
https://pubmed.ncbi.nlm.nih.gov/12470875
https://pubmed.ncbi.nlm.nih.gov/12470875
Publikováno v:
Neurochemistry international. 38(5)
Ketamine (2-o-chlorophenenyl-2-methylaminocyclohexanone hydrochloride) is a dissociative general anaesthetic with neuroprotective properties. Since ketamine is optically active, we compared the neuroprotective efficacy of the (+)- or (-)-enantiomers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82314fd16d10c4d78aa0e6f121f7d997
https://pubmed.ncbi.nlm.nih.gov/11222916
https://pubmed.ncbi.nlm.nih.gov/11222916
Publikováno v:
European journal of pharmacology. 340(2-3)
We investigated the functional characteristics of the NMDA receptor that modulates hypoxia/hypoglycaemia-induced striatal dopamine release. Dopamine release was detected by fast cyclic voltammetry in rat neostriatal slices. Four variables were measur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25c9526646a80380255aaa6abafd2430
https://pubmed.ncbi.nlm.nih.gov/9537807
https://pubmed.ncbi.nlm.nih.gov/9537807