Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Christopher C. Shelton"'
Autor:
Gary K. Schwartz, Philip B. Paty, Daniel Notterman, Li-Xuan Qin, Yue-Ming Li, Christopher C. Shelton, Raymond D. Meng
Because Notch signaling is implicated in colon cancer tumorigenesis and protects cells from apoptosis by inducing prosurvival targets, it was hypothesized that inhibition of Notch signaling with γ-secretase inhibitors (GSI) may enhance the chemosens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::577ee88e5616221b0e76c0cd52f57018
https://doi.org/10.1158/0008-5472.c.6499221.v1
https://doi.org/10.1158/0008-5472.c.6499221.v1
Autor:
Gary K. Schwartz, Philip B. Paty, Daniel Notterman, Li-Xuan Qin, Yue-Ming Li, Christopher C. Shelton, Raymond D. Meng
Supplementary Figure 2 from γ-Secretase Inhibitors Abrogate Oxaliplatin-Induced Activation of the Notch-1 Signaling Pathway in Colon Cancer Cells Resulting in Enhanced Chemosensitivity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3349e452f9e5aa7442538a51831c31bd
https://doi.org/10.1158/0008-5472.22379322
https://doi.org/10.1158/0008-5472.22379322
Autor:
Yuan Tian, Kwangwook Ahn, Yue-Ming Li, M. Lane Gilchrist, Christopher C. Shelton, Xulun Zhang, Sangram S. Sisodia
Publikováno v:
Proceedings of the National Academy of Sciences. 107:21435-21440
A complex composed of presenilin (PS), nicastrin, PEN-2, and APH-1 is absolutely required for γ-secretase activity in vivo. Evidence has emerged to suggest a role for PS as the catalytic subunit of γ-secretase, but it has not been established that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d3d0c776efa7ee351ff051a7961971a
https://doi.org/10.1073/pnas.1013246107
https://doi.org/10.1073/pnas.1013246107
Autor:
Christopher C. Shelton, Deming Chau, Lei Zhu, Li Yang, Yue-Ming Li, Hakim Djaballah, Rong Wang, Hui Zheng
Publikováno v:
Proceedings of the National Academy of Sciences. 106:20228-20233
gamma-Secretase cleaves multiple substrates within the transmembrane domain that include the amyloid precursor protein as well as the Notch family of receptors. These substrates are associated with Alzheimer disease and cancer. Despite extensive inve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::788898118680a4752e4da1e9e95de696
https://doi.org/10.1073/pnas.0910757106
https://doi.org/10.1073/pnas.0910757106
Publikováno v:
ASSAY and Drug Development Technologies. 7:461-470
gamma-Secretase is an aspartyl protease that cleaves multiple substrates including the amyloid precursor protein (APP) and the Notch proteins. Abnormal proteolysis of APP is involved in the pathogenesis of Alzheimer's disease (AD) and overactive Notc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b728e832716b4595b0b018033b6075f
https://doi.org/10.1089/adt.2009.0202
https://doi.org/10.1089/adt.2009.0202
Autor:
Guangli Yang, Ye Ingrid Yin, Jiong Chun, Ouathek Ouerfelli, Yue Ming Li, Christopher C. Shelton
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:922-925
The stereoselective synthesis of novel photoreactive gamma-secretase inhibitors 2 and 3 has been achieved. Key steps of the strategy involve preparation of alpha-N-Boc-epoxide 8 and formation of lactone 14 in a practical and stereo-controlled fashion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff3b6b06458ae7ac0e552544b686dac0
https://doi.org/10.1016/j.bmcl.2008.11.117
https://doi.org/10.1016/j.bmcl.2008.11.117
Autor:
Billy R. Martin, Laura E. Wise, Christopher C. Shelton, Aron H. Lichtman, Benjamin F. Cravatt
Publikováno v:
European Journal of Pharmacology. 557:44-48
In the present study, we investigated whether anandamide produces its behavioral effects through a cannabinoid CB(1) receptor mechanism of action. The behavioral effects of anandamide were evaluated in mice that lacked both fatty acid amide hydrolase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f63deece52510db83777dda2d4894fc
https://doi.org/10.1016/j.ejphar.2006.11.002
https://doi.org/10.1016/j.ejphar.2006.11.002
Publikováno v:
Pain. 109:319-327
Although the N -arachidonoyl ethanolamine (anandamide) binds to cannabinoid receptors and has been implicated in the suppression of pain, its rapid catabolism in vivo by fatty acid amide hydrolase (FAAH) has presented a challenge in investigating the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbe545e4ba70054ee03267bf213e209f
https://doi.org/10.1016/j.pain.2004.01.022
https://doi.org/10.1016/j.pain.2004.01.022
Publikováno v:
Molecular Neurodegeneration, Vol 4, Iss 1, p 22 (2009)
Molecular Neurodegeneration
Molecular Neurodegeneration
γ-Secretase is an aspartyl protease that cleaves multiple substrates that are involved in broad biological processes ranging from stem cell development to neurodegeneration. The investigation of γ-secretase has been limited by currently available a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe855471d027d969169b4a0ef4896677
https://doi.org/10.1186/1750-1326-4-22
https://doi.org/10.1186/1750-1326-4-22
Autor:
Christopher C. Shelton, Li-Xuan Qin, Philip B. Paty, Yue Ming Li, Daniel A. Notterman, Raymond D. Meng, Gary K. Schwartz
Because Notch signaling is implicated in colon cancer tumorigenesis and protects cells from apoptosis by inducing prosurvival targets, it was hypothesized that inhibition of Notch signaling with γ-secretase inhibitors (GSI) may enhance the chemosens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2332cdaf50a1cd9ae6f4918f686868c
https://europepmc.org/articles/PMC3242515/
https://europepmc.org/articles/PMC3242515/