Heparan sulfate proteoglycans regulate BMP signalling during neural crest induction

Autor: Esther Bell, Christopher C. Rider, Arnold Junior Tatsinkam, James Pegge

Publikováno v: Pegge, J, Tatsinkam, A J, Rider, C C & Bell, E 2019, ' Heparan sulfate proteoglycans regulate BMP signalling during neural crest induction ', Developmental Biology, vol. 460, no. 2, pp. 108-114 . https://doi.org/10.1016/j.ydbio.2019.12.015
Developmental Biology

Bone morphogenetic protein (BMP) signalling is key to many developmental processes, including early regionalisation of the ectoderm. The neural crest is induced here by a combination of BMP and Wnt signals from nearby tissues with many secreted facto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b21ed23b728061d2000dec26328e3880
https://kclpure.kcl.ac.uk/ws/files/127051041/1_s2.0_S001216061930171X_main.pdf

The localisation of the heparin binding sites of human and murine interleukin-12 within the carboxyterminal domain of the P40 subunit

Autor: Rosemary S. Mummery, Christopher C. Rider, Pascale Garnier, Roslyn V. Gibbs, Mark J. Forster, Barbara Mulloy

Publikováno v: Garnier, P, Mummery, R, Forster, M J, Mulloy, B, Gibbs, R V & Rider, C C 2018, ' The localisation of the heparin binding sites of human and murine interleukin-12 within the carboxyterminal domain of the P40 subunit ', Cytokine, vol. 110, pp. 159-168 . https://doi.org/10.1016/j.cyto.2018.04.014
Cytokine

Graphical abstract
Highlights • We demonstrate differences in the specificity of heparin binding between human and murine IL-12s. • Heparin predominantly protects the p40 subunit against proteolysis by LysC. • A truncated IL-12 polypeptide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::346d53b1c0f2dabd969962ec735b12a6
https://researchportal.port.ac.uk/portal/en/publications/the-localisation-of-the-heparin-binding-sites-of-human-and-murine-interleukin12-within-the-carboxyterminal-domain-of-the-p40-subunit(17fa1c3b-3fef-4dde-983d-78fdeb4628e3).html

Cell-surface heparan sulfate facilitates human immunodeficiency virus Type 1 entry into some cell lines but not primary lymphocytes

Autor: Jamal Ibrahim, Philip Griffin, Christopher C. Rider, Deirdre R. Coombe, William James

Many viruses have evolved to exploit cell-surface glycosaminoglycans (GAG), particularly heparan sulfate, to facilitate their attachment and infection of host cells. Here, the case for the involvement of heparan sulfate GAG in cellular infection by h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91f5ba9d47461aba262a32d019726bf1
https://ora.ox.ac.uk/objects/uuid:2fa99a6e-8aea-44fe-92c5-3758b2e9b258

The binding of human betacellulin to heparin, heparan sulfate and related polysaccharides

Autor: Barbara Mulloy, Christopher C. Rider, Rosemary S. Mummery

Publikováno v: Glycobiology. 17:1094-1103

Recombinant human betacellulin binds strongly to heparin, requiring of the order of 0.8 M NaCl for its elution from a heparin affinity matrix. This is in complete contrast to the prototypic member of its cytokine superfamily, epidermal growth factor,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::236a3c3448bf08b21aee086d46d5f297
https://doi.org/10.1093/glycob/cwm082

Cytokines and proteoglycans: an introductory overview

Autor: Barbara Mulloy, Christopher C. Rider

Publikováno v: Biochemical Society Transactions. 34:409-413

The defining characteristic of the glycoproteins known as proteoglycans is the presence of O-linked acidic polysaccharides known as GAGs (glycosaminoglycans). The backbone of these linear polysaccharides is a repeating disaccharide, comprising N-acet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9f5b57da4afebbe6fcf10d57dfb295d
https://doi.org/10.1042/bst0340409