Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Christopher C. Meoli"'
Autor:
Daniel J Fazakerley, Rima Chaudhuri, Pengyi Yang, Ghassan J Maghzal, Kristen C Thomas, James R Krycer, Sean J Humphrey, Benjamin L Parker, Kelsey H Fisher-Wellman, Christopher C Meoli, Nolan J Hoffman, Ciana Diskin, James G Burchfield, Mark J Cowley, Warren Kaplan, Zora Modrusan, Ganesh Kolumam, Jean YH Yang, Daniel L Chen, Dorit Samocha-Bonet, Jerry R Greenfield, Kyle L Hoehn, Roland Stocker, David E James
Publikováno v:
eLife, Vol 7 (2018)
Insulin resistance in muscle, adipocytes and liver is a gateway to a number of metabolic diseases. Here, we show a selective deficiency in mitochondrial coenzyme Q (CoQ) in insulin-resistant adipose and muscle tissue. This defect was observed in a ra
Externí odkaz:
https://doaj.org/article/8a5796fc74b24c25b9c3c989e6b15e61
Autor:
P. Tess Whitworth, Ee Cheng Khor, Kyle L. Hoehn, Xiuquan Ma, James Cantley, Belinda Yau, Christopher C. Meoli, James G. Burchfield, Natalie K.Y. Wee, Jacqueline Stöckli, James R. Krycer, Shi-Xlong Tan, Annabel Y. Minard, Paul A. Baldock, Nolan J. Hoffman, Daniel J. Fazakerley, Marin E. Nelson, Trevor J. Biden, Gregory J. Cooney, Amanda L. Wright, Ronaldo F. Enriquez, Melkam A. Kebede, Kristen C. Thomas, David E. James, Bryce Vissel
© 2018 by The American Society for Biochemistry and Molecular Biology, Inc. Obesity is associated with metabolic dysfunction, including insulin resistance and hyperinsulinemia, and with disorders such as cardiovascular disease, osteoporosis, and neu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c71f02bc8840d707632c2abc83e61c6c
https://acuresearchbank.acu.edu.au/item/8qx48/high-dietary-fat-and-sucrose-results-in-an-extensive-and-time-dependent-deterioration-in-health-of-multiple-physiological-systems-in-mice
https://acuresearchbank.acu.edu.au/item/8qx48/high-dietary-fat-and-sucrose-results-in-an-extensive-and-time-dependent-deterioration-in-health-of-multiple-physiological-systems-in-mice
Autor:
Kyle L. Hoehn, Jerry R. Greenfield, Warren Kaplan, Ganesh Kolumam, James G. Burchfield, David E. James, Nolan J. Hoffman, Daniel L. T Chen, Jean Yh Yang, Ciana Diskin, Kelsey H. Fisher-Wellman, Sean J. Humphrey, Ghassan J. Maghzal, Kristen C. Thomas, Benjamin L. Parker, James R. Krycer, Zora Modrusan, Rima Chaudhuri, Roland Stocker, Daniel J. Fazakerley, Pengyi Yang, Dorit Samocha-Bonet, Christopher C. Meoli, Mark J. Cowley
Publikováno v:
eLife, Vol 7 (2018)
eLife
eLife
Insulin resistance in muscle, adipocytes and liver is a gateway to a number of metabolic diseases. Here, we show a selective deficiency in mitochondrial coenzyme Q (CoQ) in insulin-resistant adipose and muscle tissue. This defect was observed in a ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3f4f9362349b13b51a6a6ef1d39528a
https://acuresearchbank.acu.edu.au/item/8q630/mitochondrial-coq-deficiency-is-a-common-driver-of-mitochondrial-oxidants-and-insulin-resistance
https://acuresearchbank.acu.edu.au/item/8q630/mitochondrial-coq-deficiency-is-a-common-driver-of-mitochondrial-oxidants-and-insulin-resistance
Autor:
Daniel J Fazakerley, Rima Chaudhuri, Pengyi Yang, Ghassan J Maghzal, Kristen C Thomas, James R Krycer, Sean J Humphrey, Benjamin L Parker, Kelsey H Fisher-Wellman, Christopher C Meoli, Nolan J Hoffman, Ciana Diskin, James G Burchfield, Mark J Cowley, Warren Kaplan, Zora Modrusan, Ganesh Kolumam, Jean YH Yang, Daniel L Chen, Dorit Samocha-Bonet, Jerry R Greenfield, Kyle L Hoehn, Roland Stocker, David E James
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd9dfd56169a522c67aa9961c46fd768
https://doi.org/10.7554/elife.32111.032
https://doi.org/10.7554/elife.32111.032
Autor:
Christopher C. Meoli, James G. Burchfield, Sheyda Naghiloo, Matthew J. Prior, Daniel J. Fazakerley, Benjamin L. Parker, Jacqueline Stöckli, Rima Chaudhuri, David E. James, Beverley A. Murrow, Geoffrey D. Holman, James R. Krycer, Kristen C. Thomas, Francoise Koumanov
Publikováno v:
The Journal of Biological Chemistry
Background: We searched for novel regulators of insulin-stimulated glucose transport in adipocytes. Results: Tumor suppressor candidate 5 (TUSC5) colocalized with GLUT4, and manipulation of TUSC5 expression levels affected insulin-regulated glucose t
Autor:
Salvatore P. Mangiafico, Kari Wong, Olga Ilkayeva, Nolan J. Hoffman, Daniel J. Fazakerley, Jacqueline Stöckli, Chrysovalantou E. Xirouchaki, Chieh Hsin Yang, Gregory J. Cooney, Xiao Yi Zeng, Christopher C. Meoli, Kristen C. Thomas, Sofianos Andrikopoulos, David E. James, Kelsey H. Fisher-Wellman, Rima Chaudhuri, Deborah M. Muoio
Publikováno v:
The Journal of biological chemistry. 292(47)
Insulin resistance is a major risk factor for many diseases. However, its underlying mechanism remains unclear in part because it is triggered by a complex relationship between multiple factors, including genes and the environment. Here, we used meta
Autor:
James G. Burchfield, Sofianos Andrikopoulos, Lindsay E. Wu, David E. James, David G. Le Couteur, Chrysovalantou E. Xirouchaki, Myung Jin Kang, Elizabeth E. Powter, Ganesh Kolumam, Daniel J. Fazakerley, Salvatore P. Mangiafico, Nicholas van Bruggen, Mashani Mohamad, Victoria C. Cogger, Jacqueline Stöckli, Himani Pant, A. Stefanie Mikolaizak, Jennifer R. Gamble, Gregory J. Cooney, Christopher C. Meoli
Publikováno v:
Diabetes. 63:2656-2667
The vascular endothelial growth factor (VEGF) family of cytokines are important regulators of angiogenesis that have emerged as important targets for the treatment of obesity. While serum VEGF levels rise during obesity, recent studies using genetic
Autor:
Alexander J. Groffen, James G. Burchfield, James Cantley, Himani Pant, P.T. Whitworth, David E. James, Jia Li, Christopher C. Meoli, Rima Chaudhuri, Jacqueline Stöckli, Matthijs Verhage
Publikováno v:
Li, J, Cantley, J, Burchfield, J G, Meoli, C C, Stöckli, J, Whitworth, P T, Pant, H, Chaudhuri, R, Groffen, A J A, Verhage, M & James, D E 2014, ' DOC2 isoforms play dual roles in insulin secretion and insulin-stimulated glucose uptake ', Diabetologia, vol. 57, no. 10, pp. 2173-2182 . https://doi.org/10.1007/s00125-014-3312-y
Diabetologia, 57(10), 2173-2182. Springer Verlag
Diabetologia, 57(10), 2173-2182. Springer Verlag
Glucose-stimulated insulin secretion (GSIS) and insulin-stimulated glucose uptake are processes that rely on regulated intracellular vesicle transport and vesicle fusion with the plasma membrane. DOC2A and DOC2B are calcium-sensitive proteins that we
Autor:
Gordon J. King, Shu-Hong Hu, Andrew E. Whitten, Jagath Reddy Junutula, Jacqueline Stöckli, Christopher C. Meoli, David E. James, Russell Jarrott, Brit Winnen, Jennifer L. Martin, Wilko Duprez
Publikováno v:
Journal of Biological Chemistry. 287:40996-41006
The APPL1 and APPL2 proteins (APPL (adaptor protein, phosphotyrosine interaction, pleckstrin homology (PH) domain, and leucine zipper-containing protein)) are localized to their own endosomal subcompartment and interact with a wide range of proteins
Autor:
Yvonne Ng, Adelle C.F. Coster, Shi-Xiong Tan, Christopher C. Meoli, Himani Pant, Daniel J. Fazakerley, Jacqueline Stöckli, David E. James, Jia Li, Kelsey H. Fisher-Wellman
Aside from glucose metabolism, insulin regulates a variety of pathways in peripheral tissues. Under insulin-resistant conditions, it is well known that insulin-stimulated glucose uptake is impaired, and many studies attribute this to a defect in Akt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72b3f58f782eb5dbfdd36190fbf2b1a3
https://europepmc.org/articles/PMC4416839/
https://europepmc.org/articles/PMC4416839/