Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Christopher C. Lapish"'
Autor:
Nicholas M. Timme, Baofeng Ma, David Linsenbardt, Ethan Cornwell, Taylor Galbari, Christopher C. Lapish
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Compulsive alcohol drinking is a core feature of alcohol use disorder. Here the authors find that in rodents, neural signals in a key decision-making brain region (dmPFC) shift from behavioral control to alcohol seeking during compulsive alcohol drin
Externí odkaz:
https://doaj.org/article/2208bf4b40174f739bb94bc4adf8927f
Publikováno v:
Entropy, Vol 22, Iss 5, p 580 (2020)
Information theory is a powerful tool for analyzing complex systems. In many areas of neuroscience, it is now possible to gather data from large ensembles of neural variables (e.g., data from many neurons, genes, or voxels). The individual variables
Externí odkaz:
https://doaj.org/article/e9639105a4e148fb83a2e35b4ba18676
Publikováno v:
Journal of Clinical and Translational Science, Vol 1, Pp 40-40 (2017)
OBJECTIVES/SPECIFIC AIMS: Motivation deficits are one of the strongest determinants of poor functional outcomes in people with schizophrenia. Mobile interventions are a promising approach to improving these deficits, as they can provide frequent cues
Externí odkaz:
https://doaj.org/article/b510f78d7f2542518b18dad1facd2d7b
Publikováno v:
PLoS Computational Biology, Vol 12, Iss 12, p e1005233 (2016)
The dynamics of neuronal excitability determine the neuron's response to stimuli, its synchronization and resonance properties and, ultimately, the computations it performs in the brain. We investigated the dynamical mechanisms underlying the excitab
Externí odkaz:
https://doaj.org/article/6ba0043144854bd387b2de1a55bb697f
Autor:
Yu Tian Wang, Lily R. Aleksandrova, Donovan M. Ashby, Christopher C. Lapish, Carine Dias, Anthony G. Phillips
Publikováno v:
International Journal of Neuropsychopharmacology
Background Latent inhibition (LI) reflects an adaptive form of learning impaired in certain forms of mental illness. Glutamate receptor activity is linked to LI, but the potential role of synaptic plasticity remains unspecified. Methods Accordingly,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::904933d7d4da08c95944d2765bda1790
https://doi.org/10.1093/ijnp/pyab011
https://doi.org/10.1093/ijnp/pyab011
Publikováno v:
PLOS ONE. 18:e0279841
Cortical and basal ganglia circuits play a crucial role in the formation of goal-directed and habitual behaviors. In this study, we investigate the cortico-striatal circuitry involved in learning and the role of this circuitry in the emergence of inf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ab0044ee58c7052049668bc97250f7e
https://doi.org/10.1371/journal.pone.0279841
https://doi.org/10.1371/journal.pone.0279841
This paper is now published open-access at Alcoholism: Clinical and Experimental Research: https://onlinelibrary.wiley.com/doi/10.1111/acer.14924. Front-loading is a drinking pattern where intake is skewed toward the onset of reward access. This phen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fedb14c4fcc388d9fc1d3e5a712b0ff
https://doi.org/10.31234/osf.io/85an3
https://doi.org/10.31234/osf.io/85an3
Publikováno v:
Alcohol Clin Exp Res
BACKGROUND: The medial prefrontal cortex (mPFC) is a brain region involved in the evaluation and selection of motivationally relevant outcomes. Neural activity in mPFC is altered following acute ethanol (EtOH) use and, in rodent models, doses as low
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4a14c61680aa9c82ec952c66c2dec8a
https://doi.org/10.1111/acer.14463
https://doi.org/10.1111/acer.14463
Publikováno v:
Alcohol Clin Exp Res
Background Beyond yielding high blood ethanol (EtOH) concentrations (BECs), binge-drinking models allow examination of drinking patterns which may be associated with EtOH's rewarding effects, including front-loading and consummatory successive negati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c46200dbff31174482625c2a3cf9e7b1
https://doi.org/10.1111/acer.14419
https://doi.org/10.1111/acer.14419
Dissertation/ Thesis
Problematic alcohol consumption develops concurrently with deficits in decision-making. These deficits may be due to alterations in dorsal medial prefrontal cortex (dmPFC) neural activity, as it is essential for the evaluation and implementation of b