Zobrazeno 1 - 10
of 108
pro vyhledávání: '"Christopher C. Lai"'
Autor:
Sumirtha Balaratnam, Curran Rhodes, Desta Doro Bume, Colleen Connelly, Christopher C. Lai, James A. Kelley, Kamyar Yazdani, Philip J. Homan, Danny Incarnato, Tomoyuki Numata, John S. Schneekloth Jr
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
The small modified nucleotide PreQ1 binds to the PreQ1 riboswitch and regulates gene expression by inducing RNA conformation change. Here the authors design and characterize a specific preQ1-derived probe by x-ray crystallography, mass spectral analy
Externí odkaz:
https://doaj.org/article/c3fe0cb68393406ba791bbafef33d2f3
Autor:
Yumeng Wu, Chengrun Tang, Ruomei Rui, Liumeng Yang, Wei Ding, Jiangyuan Wang, Yiming Li, Christopher C. Lai, Yueping Wang, Ronghua Luo, Weilie Xiao, Hongbing Zhang, Yongtang Zheng, Yanping He
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 10, Iss 3, Pp 512-528 (2020)
A series of 2-(((5-akly/aryl-1H-pyrazol-3-yl)methyl)thio)-5-alkyl-6-(cyclohexylmethyl)-pyrimidin-4(3H)-ones were synthesized and their anti-HIV-1 activities were evaluated. Most of these compounds were highly active against wild-type (WT) HIV-1 strai
Externí odkaz:
https://doaj.org/article/7d525690913f449f9b92e02272fa7654
Autor:
Wu Yumeng, Chengrun Tang, Wei Ding, Yue-Ping Wang, Wei-Lie Xiao, Yong-Tang Zheng, Hongbing Zhang, Yi-Ming Li, Yan-Ping He, Jiangyuan Wang, Christopher C. Lai, Liu-Meng Yang, Rui Ruomei, Rong-Hua Luo
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 10, Iss 3, Pp 512-528 (2020)
A series of 2-(((5-akly/aryl-1H-pyrazol-3-yl)methyl)thio)-5-alkyl-6-(cyclohexylmethyl)-pyrimidin-4(3H)-ones were synthesized and their anti-HIV-1 activities were evaluated. Most of these compounds were highly active against wild-type (WT) HIV-1 strai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::054483f4db1260ba67ef0781bbe61d50
http://www.sciencedirect.com/science/article/pii/S2211383519303909
http://www.sciencedirect.com/science/article/pii/S2211383519303909
Autor:
Nimit L. Patel, Lixin Fan, Georg J. Furtmüller, Yun Xing Wang, Yichuan Zhang, Jason R. Stagno, Christopher C. Lai, Byoung Chol Oh, Poulami Majumder, Joel P. Schneider, Marcos Iglesias, Giorgio Raimondi, James A. Kelley, Caroline Andrews, Gerald Brandacher
Publikováno v:
Small
Combination therapies that target multiple pathways involved in immune rejection of transplants hold promise for patients in need of restorative surgery. Herein, a non-interacting multiphase molecular assembly approach is developed to crystallize tof
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3d7c8f7e695e5eef5760eddda4b65d1
https://pubmed.ncbi.nlm.nih.gov/32812339
https://pubmed.ncbi.nlm.nih.gov/32812339
Publikováno v:
Monatshefte für Chemie - Chemical Monthly. 149:1919-1929
Quantum mechanical and hybrid QM/QM′ ONIOM methodology have been applied to investigate the structure and molecular interactions between DB08446 and the binding site of HIV-1 RT. The binding energy calculated using the ONIOM2(M06-2X-D3/6-311 + G(2d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f13fbe04132019163babd113d5207b94
https://doi.org/10.1007/s00706-018-2239-2
https://doi.org/10.1007/s00706-018-2239-2
Autor:
Lucía Gandolfi Donadío, James A. Kelley, Xiaoling Zhou, Lia Cynthia Garcia, Christopher C. Lai, Megan L. Peach, Nancy E. Lewin, Maria Julieta Comin, Peter M. Blumberg, Eleonora Elhalem
Publikováno v:
Bioorganic & Medicinal Chemistry. 25:2971-2980
C1 domain-containing proteins, such as protein kinase C (PKC), have a central role in cellular signal transduction. Their involvement in many diseases, including cancer, cardiovascular disease, and immunological and neurological disorders has been ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82ed507ec724289cb336f8d8748c1ca1
https://doi.org/10.1016/j.bmc.2017.03.022
https://doi.org/10.1016/j.bmc.2017.03.022
Autor:
Feng Yue, Xian Chen, Wu Daochun, Wang Yueping, Xia Xueshan, Yan-Ping He, Cong Li, Hua Wang, Yang Junfeng, Yufang Zhang, Christopher C. Lai
Publikováno v:
Medicinal Chemistry Research. 26:1388-1396
A novel series of dihydro-hydroxyl-phene-thylsulfanyl-ω-cyclohexyl/phenyl-oxopyrimidine derivatives have been synthesized and their in vitro anti-hepatitis C virus activities have been evaluated using Huh 7.5.1 cells. Some of the compounds showed mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88550737eaff06dd847e136c22a6708f
https://doi.org/10.1007/s00044-017-1815-z
https://doi.org/10.1007/s00044-017-1815-z
Autor:
Yumeng, Wu, Chengrun, Tang, Ruomei, Rui, Liumeng, Yang, Wei, Ding, Jiangyuan, Wang, Yiming, Li, Christopher C, Lai, Yueping, Wang, Ronghua, Luo, Weilie, Xiao, Hongbing, Zhang, Yongtang, Zheng, Yanping, He
Publikováno v:
Acta Pharmaceutica Sinica. B
A series of 2-(((5-akly/aryl-1H-pyrazol-3-yl)methyl)thio)-5-alkyl-6-(cyclohexylmethyl)-pyrimidin-4(3H)-ones were synthesized and their anti-HIV-1 activities were evaluated. Most of these compounds were highly active against wild-type (WT) HIV-1 strai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f160629f962dcf4a578b86063064ee67
https://pubmed.ncbi.nlm.nih.gov/32140396
https://pubmed.ncbi.nlm.nih.gov/32140396
Autor:
Terrence R. Burke, Jung-Eun Park, James A. Kelley, Wen-Jian Qian, Robert A. Grant, Kyung S. Lee, Michael B. Yaffe, Christopher C. Lai
Publikováno v:
Biopolymers. 104:663-673
Our recently discovered, selective, on-resin route to N(τ)-alkylated imidazolium-containing histidine residues affords new strategies for peptide mimetic design. In this, we demonstrate the use of this chemistry to prepare a series of macrocyclic ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a7685d765a9a57f2529171a1e0aceef
https://doi.org/10.1002/bip.22698
https://doi.org/10.1002/bip.22698
Autor:
Wen-Jian Qian, Kyung S. Lee, Suk-Youl Park, Daniel Lim, James A. Kelley, Jung-Eun Park, Michael B. Yaffe, Christopher C. Lai, Terrence R. Burke, Ki Won Lee
Publikováno v:
Biopolymers. 102:444-455
Binding of polo-like kinase 1 (Plk1) polo-box domains (PBDs) to phosphothreonine (pThr)/phosphoserine (pSer)-containing sequences is critical for the proper function of Plk1. Although high-affinity synthetic pThr-containing peptides provide starting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::537ba48eaa7c11f13c377ef0aa48834e
https://doi.org/10.1002/bip.22569
https://doi.org/10.1002/bip.22569