Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Christopher C. Forbes"'
Publikováno v:
Journal of the American Chemical Society. 128:9211-9218
A series of membrane-spanning bolaamphiphiles (molecules with two hydrophilic end-groups connected by a hydrophobic linker) were prepared by a modular synthetic method and evaluated for their abilities to affect the dynamics of a surrounding bilayer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea4366c405b4fd09e97885e9f21486c8
https://doi.org/10.1021/ja0619253
https://doi.org/10.1021/ja0619253
Autor:
Olaf Wiest, Bradley D. Smith, Martin J. Deetz, Christopher C. Forbes, Marco Jonas, Jeremiah P. Malerich
Publikováno v:
The Journal of Organic Chemistry. 67:3949-3952
The barrier for rotation about an N-alkylcarbamate C(carbonyl)-N bond is around 16 kcal/mol. In the case of an N-phenylcarbamate, the rotational barrier is lowered to 12.5 kcal/mol, but with N-(2-pyrimidyl)carbamates the barriers are so low (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cd95f95ac581244ce916078641a9cb6
https://doi.org/10.1021/jo025554u
https://doi.org/10.1021/jo025554u
Autor:
Dennis Klimpel, Malika Kumarasiri, Masahiro Ikejiri, Christopher C. Forbes, Mijoon Lee, Shahriar Mobashery, Dusan Hesek, Marta Toth, Mana Espahbodi, Bruce C. Noll, Mayland Chang
An extensive structure-activity relationship study with the template of 2-(4-phenoxyphenylsulfonylmethyl)thiirane (1), a potent and highly selective inhibitor for human gelatinases, is reported herein. Syntheses of 65 new analogues, each in multistep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::210cc56c6dba4c4fae89fb57e9783702
https://hdl.handle.net/11541.2/121287
https://hdl.handle.net/11541.2/121287
Autor:
Marta Toth, Qicun Shi, Mijoon Lee, Shahriar Mobashery, Christopher C. Forbes, Jed F. Fisher, Rafael Fridman, Leticia I. Llarrull, Michael Gossing, Dusan Hesek
Publikováno v:
Chemical biologydrug design. 74(6)
(+/-)-2-[(4-Phenoxyphenylsulfonyl)methyl]thiirane 1 is a potent and selective mechanism-based inhibitor of the gelatinase sub-class of the zinc-dependent matrix metalloproteinase family. Inhibitor 1 has excellent activity in in vivo models of gelatin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c67739b19918de50e2f487516492ede1
https://pubmed.ncbi.nlm.nih.gov/19807733
https://pubmed.ncbi.nlm.nih.gov/19807733
Autor:
Adriel Villegas-Estrada, Marta Toth, Rafael Fridman, Mayland Chang, Christopher C. Forbes, Gloria Kreitinger, Giuseppe Celenza, Bill Boggess, Mijoon Lee, Shahriar Mobashery
(4-Phenoxyphenylsulfonyl)methylthiirane (inhibitor 1) is a highly selective inhibitor of gelatinases (matrix metalloproteinases 2 and 9), which is showing considerable promise in animal models for cancer and stroke. Despite demonstrated potent, selec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da50604831697f7c5fa9f787f98ed0bd
http://hdl.handle.net/11697/4939
http://hdl.handle.net/11697/4939
Publikováno v:
ChemInform. 36
There is a demand for new methods of protecting organic dyes from aggregation effects and photochemical degradation. The purpose of this microreview is to summarize the recent attempts to improve the properties of dyes by molecular encapsulation. Org
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6daf9376d9bc955459a41c4c9276cf2
https://doi.org/10.1002/chin.200549274
https://doi.org/10.1002/chin.200549274
Publikováno v:
Journal of the American Chemical Society. 127(10)
A squaraine dye with bulky end groups is employed as the thread component in two Leigh-type amide rotaxanes. The rotaxanes are synthesized in a simple two-step process. X-ray crystal structures of the rotaxanes show that the pyridyl-containing macroc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27f243ed2227ba358d193d9922fd56e6
https://pubmed.ncbi.nlm.nih.gov/15755140
https://pubmed.ncbi.nlm.nih.gov/15755140
Publikováno v:
Organic letters. 3(22)
[reaction: see text]. N-(pyrimidin-2-yl)pentafluorobenzamide adopts a cis amide bond in the solid state with a pyrimidyl nitrogen pointing toward the center of the perfluorophenyl ring. In solution, the compound is a mixture of cis and trans rotamers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3a520b91050f096a2ba324719c07ba0
https://pubmed.ncbi.nlm.nih.gov/11678717
https://pubmed.ncbi.nlm.nih.gov/11678717
Autor:
Bill Boggess, Christopher C. Forbes, William R. Wolter, Mayland Chang, Mark A. Suckow, Mijoon Lee, Shahriar Mobashery, Giuseppe Celenza, Adriel Villegas-Estrada
Publikováno v:
Chemical Biology & Drug Design. :080125065906037
(4-Phenoxyphenylsulfonyl)methylthiirane (compound 1) is a highly selective and potent inhibitor of gelatinases that shows considerable promise in animal models for cancer and stroke. The metabolism of compound 1 was investigated in mice, following in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::947bddde6522893015d544be82532e2d
https://doi.org/10.1111/j.1747-0277.2008.00632.x
https://doi.org/10.1111/j.1747-0277.2008.00632.x