Testosterone and long pulse width stimulation (TLPS) for denervated muscles after spinal cord injury: a study protocol of randomised clinical trial

Autor: Ashraf S Gorgey, Refka E Khalil, Ranjodh Gill, Teodoro Castillo, David X Cifu, Edward J Lesnefsky, Robert A Adler, Malak Alrubaye, Jeannie Rivers, Lance L Goetz, Deborah Caruso, Timothy D Lavis, Christopher C Cardozo

Publikováno v: BMJ Open, Vol 12, Iss 10 (2022)

Introduction Long pulse width stimulation (LPWS; 120–150 ms) has the potential to stimulate denervated muscles and to restore muscle size in denervated people with spinal cord injury (SCI). We will determine if testosterone treatment (TT)+LPWS woul

Externí odkaz: https://doaj.org/article/877316f48e42419abf50624a7a587852

Sclerostin Antibody Preserves the Morphology and Structure of Osteocytes and Blocks the Severe Skeletal Deterioration After Motor-Complete Spinal Cord Injury in Rats

Autor: Yinshi Ren, Yiwen Qin, Shijia Zheng, Jiliang Li, William A. Bauman, Xiaodong Li, Jie Sun, Weiping Qin, Lauren Harlow, Hua Zhu Ke, Christopher C Cardozo, Yingjie Wu, Jian Q. Feng, Thomas P. Brown, Yuanzhen Peng

Publikováno v: Journal of Bone and Mineral Research. 30:1994-2004

Unloading, neural lesions, and hormonal disorders after acute motor-complete spinal cord injury (SCI) cause one of the most severe forms of bone loss, a condition that has been refractory to available interventions tested to date. Thus, these feature

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::14fbbaff0032660176458c49ed35194a
https://doi.org/10.1002/jbmr.2549

Advanced Methodology for Rapid Isolation of Single Myofibers from Flexor Digitorum Brevis Muscle.

Autor: Awad K; Bone Muscle Research Center, College of Nursing and Health Innovations, Department of Graduate Nursing, University of Texas at Arlington, Arlington, Texas, USA., Moore L; Bone Muscle Research Center, College of Nursing and Health Innovations, Department of Graduate Nursing, University of Texas at Arlington, Arlington, Texas, USA., Huang J; Bone Muscle Research Center, College of Nursing and Health Innovations, Department of Graduate Nursing, University of Texas at Arlington, Arlington, Texas, USA., Gomez L; Bone Muscle Research Center, College of Nursing and Health Innovations, Department of Graduate Nursing, University of Texas at Arlington, Arlington, Texas, USA., Brotto L; Bone Muscle Research Center, College of Nursing and Health Innovations, Department of Graduate Nursing, University of Texas at Arlington, Arlington, Texas, USA., Varanasi V; Bone Muscle Research Center, College of Nursing and Health Innovations, Department of Graduate Nursing, University of Texas at Arlington, Arlington, Texas, USA., Cardozo C; National Center for the Medical Consequences of Spinal Cord Injury, James J. Peters Department of Veterans Affairs Medical Center, New York, New York, USA.; Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Weisleder N; Department of Physiology and Cell Biology, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio, USA., Pan Z; Bone Muscle Research Center, College of Nursing and Health Innovations, Department of Graduate Nursing, University of Texas at Arlington, Arlington, Texas, USA., Zhou J; Bone Muscle Research Center, College of Nursing and Health Innovations, Department of Graduate Nursing, University of Texas at Arlington, Arlington, Texas, USA., Bonewald L; Indiana Center for Musculoskeletal Health, Indiana University Medical School, Indianapolis, Indiana, USA., Brotto M; Bone Muscle Research Center, College of Nursing and Health Innovations, Department of Graduate Nursing, University of Texas at Arlington, Arlington, Texas, USA.

Publikováno v: Tissue engineering. Part C, Methods [Tissue Eng Part C Methods] 2023 Aug; Vol. 29 (8), pp. 349-360. Date of Electronic Publication: 2023 May 24.

Myostatin inhibits insulin-like growth factor 1-dependent citrate secretion and osteogenesis via nicotinamide adenine dinucleotide phosphate oxidase-4 in a mouse mesenchymal stem cell line.

Autor: Liu XH; National Center for the Medical Consequences of Spinal Cord Injury, James J. Peter VA Medical Center, Bronx, New York, USA.; Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Pan JP; National Center for the Medical Consequences of Spinal Cord Injury, James J. Peter VA Medical Center, Bronx, New York, USA., Bauman WA; National Center for the Medical Consequences of Spinal Cord Injury, James J. Peter VA Medical Center, Bronx, New York, USA.; Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Medical Service, James J. Peter VA Medical Center, Bronx, New York, USA.; Department of Rehabilitation Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Bone Program, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Cardozo C; National Center for the Medical Consequences of Spinal Cord Injury, James J. Peter VA Medical Center, Bronx, New York, USA.; Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Medical Service, James J. Peter VA Medical Center, Bronx, New York, USA.; Department of Rehabilitation Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Bone Program, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Publikováno v: Annals of the New York Academy of Sciences [Ann N Y Acad Sci] 2022 Nov; Vol. 1517 (1), pp. 203-212. Date of Electronic Publication: 2022 Sep 07.

Electrical stimulation of hindlimb skeletal muscle has beneficial effects on sublesional bone in a rat model of spinal cord injury.

Autor: Zhao W; National Center for the Medical Consequences of SCI, James J. Peters VA Medical Center, Bronx, NY, USA; Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Peng Y; National Center for the Medical Consequences of SCI, James J. Peters VA Medical Center, Bronx, NY, USA., Hu Y; Department of Biomedical Engineering, Columbia University, New York, NY, USA., Guo XE; Department of Biomedical Engineering, Columbia University, New York, NY, USA., Li J; Indiana University Purdue University Indianapolis, Indianapolis, IN, USA., Cao J; United States Department of Agriculture Agricultural Research Service Human Nutrition Research Center, Grand Forks, ND, USA., Pan J; National Center for the Medical Consequences of SCI, James J. Peters VA Medical Center, Bronx, NY, USA., Feng JQ; Baylor College of Dentistry, TX A&M, Dallas, TX, USA., Cardozo C; National Center for the Medical Consequences of SCI, James J. Peters VA Medical Center, Bronx, NY, USA; Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Rehabilitation Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Jarvis J; School of Sport and Exercise Sciences, Liverpool John Moores University, Liverpool L3 3AF, United Kingdom., Bauman WA; National Center for the Medical Consequences of SCI, James J. Peters VA Medical Center, Bronx, NY, USA; Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Rehabilitation Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Qin W; National Center for the Medical Consequences of SCI, James J. Peters VA Medical Center, Bronx, NY, USA; Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address: weiping.qin@mssm.edu.

Publikováno v: Bone [Bone] 2021 Mar; Vol. 144, pp. 115825. Date of Electronic Publication: 2020 Dec 19.