Comparative analysis of proteome and transcriptome variation in mouse.

Autor: Anatole Ghazalpour, Brian Bennett, Vladislav A Petyuk, Luz Orozco, Raffi Hagopian, Imran N Mungrue, Charles R Farber, Janet Sinsheimer, Hyun M Kang, Nicholas Furlotte, Christopher C Park, Ping-Zi Wen, Heather Brewer, Karl Weitz, David G Camp, Calvin Pan, Roumyana Yordanova, Isaac Neuhaus, Charles Tilford, Nathan Siemers, Peter Gargalovic, Eleazar Eskin, Todd Kirchgessner, Desmond J Smith, Richard D Smith, Aldons J Lusis

Publikováno v: PLoS Genetics, Vol 7, Iss 6, p e1001393 (2011)

The relationships between the levels of transcripts and the levels of the proteins they encode have not been examined comprehensively in mammals, although previous work in plants and yeast suggest a surprisingly modest correlation. We have examined t

Externí odkaz: https://doaj.org/article/63664e45601942ab95c1f5cacfda19f8

Dual spatial maps of transcript and protein abundance in the mouse brain

Autor: Wei-Jun Qian, Desmond J. Smith, Richard D. Smith, Christopher C. Park, Vladislav A. Petyuk

Publikováno v: Expert Review of Proteomics. 6:243-249

Integrating quantitative proteomic and transcriptomic datasets promises valuable insights in unraveling the molecular mechanisms of the brain. We concentrate on recent studies using mass spectrometry and microarray data to investigate transcript and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07c0bf810aa602040b77dda817f278ce
https://doi.org/10.1586/epr.09.46

Effects of genome-wide copy number variation on expression in mammalian cells

Autor: Arshad H. Khan, Desmond J. Smith, Christopher C. Park, Richard T. Wang, Sangtae Ahn, Kenneth Lange

Publikováno v: BMC Genomics, Vol 12, Iss 1, p 562 (2011)
Wang, RT; Ahn, S; Park, CC; Khan, AH; Lange, K; & Smith, DJ. (2011). Effects of genome-wide copy number variation on expression in mammalian cells. BMC Genomics, 12. doi: 10.1186/1471-2164-12-562. UCLA: Retrieved from: http://www.escholarship.org/uc/item/08r1570v
BMC Genomics
Wang, Richard T; Ahn, Sangtae; Park, Christopher C; Khan, Arshad H; Lange, Kenneth; & Smith, Desmond J. (2011). Effects of genome-wide copy number variation on expression in mammalian cells. BMC Genomics, 12(1), 562. doi: http://dx.doi.org/10.1186/1471-2164-12-562. Retrieved from: http://www.escholarship.org/uc/item/63w6q0rd

Background There is only a limited understanding of the relation between copy number and expression for mammalian genes. We fine mapped cis and trans regulatory loci due to copy number change for essentially all genes using a human-hamster radiation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::272ffea32f3574e9d6b7afeec695e5e1
http://www.biomedcentral.com/1471-2164/12/562

Gene networks associated with conditional fear in mice identified using a systems genetics approach

Autor: Brian J. Bennett, Simone de Jong, Arshad H. Khan, Roel A. Ophoff, Aldons J. Lusis, Christopher C. Park, Anatole Ghazalpour, Eleazar Eskin, Steve Horvath, Greg D. Gale, Charles R. Farber, Andy Lin, Desmond J. Smith, Peter Langfelder

Publikováno v: Park, Christopher C; Gale, Greg D; de Jong, Simone; Ghazalpour, Anatole; Bennett, Brian J; Farber, Charles R; et al.(2011). Gene networks associated with conditional fear in mice identified using a systems genetics approach. BMC Systems Biology, 5(1), 43. doi: http://dx.doi.org/10.1186/1752-0509-5-43. Retrieved from: http://www.escholarship.org/uc/item/2tb981tf
BMC Systems Biology, Vol 5, Iss 1, p 43 (2011)
Park, CC; Gale, GD; de Jong, S; Ghazalpour, A; Bennett, BJ; Farber, CR; et al.(2011). Gene networks associated with conditional fear in mice identified using a systems genetics approach. BMC Systems Biology, 5. doi: 10.1186/1752-0509-5-43. UCLA: Retrieved from: http://www.escholarship.org/uc/item/7857k7sm
BMC Systems Biology

Background Our understanding of the genetic basis of learning and memory remains shrouded in mystery. To explore the genetic networks governing the biology of conditional fear, we used a systems genetics approach to analyze a hybrid mouse diversity p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d68a24472df671055d4b7e4f14e6358b
http://www.escholarship.org/uc/item/2tb981tf

Directed mammalian gene regulatory networks using expression and comparative genomic hybridization microarray data from radiation hybrids

Autor: Desmond J. Smith, Sangtae Ahn, Richard M. Leahy, Andy Lin, Kenneth Lange, Christopher C. Park, Richard T. Wang

Publikováno v: Ahn, S; Wang, RT; Park, CC; Lin, A; Leahy, RM; Lange, K; et al.(2009). Directed mammalian gene regulatory networks using expression and comparative genomic hybridization microarray data from radiation hybrids. PLoS Computational Biology, 5(6). doi: 10.1371/journal.pcbi.1000407. UCLA: Retrieved from: http://www.escholarship.org/uc/item/97j835f8
PLoS Computational Biology
PLoS Computational Biology, Vol 5, Iss 6, p e1000407 (2009)

Meiotic mapping of quantitative trait loci regulating expression (eQTLs) has allowed the construction of gene networks. However, the limited mapping resolution of these studies has meant that genotype data are largely ignored, leading to undirected n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a571b3668f837664b22801e87ef6cd62
http://www.escholarship.org/uc/item/97j835f8