Výsledky vyhledávání - "Christopher C Park"

Akademický článek

Directed mammalian gene regulatory networks using expression and comparative genomic hybridization microarray data from radiation hybrids.

Autor: Sangtae Ahn, Richard T Wang, Christopher C Park, Andy Lin, Richard M Leahy, Kenneth Lange, Desmond J Smith

Publikováno v: PLoS Computational Biology, Vol 5, Iss 6, p e1000407 (2009)

Meiotic mapping of quantitative trait loci regulating expression (eQTLs) has allowed the construction of gene networks. However, the limited mapping resolution of these studies has meant that genotype data are largely ignored, leading to undirected n

Externí odkaz: https://doaj.org/article/fdfca47cfe294e2db74d8f40ee16d36e

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Dual spatial maps of transcript and protein abundance in the mouse brain

Autor: Wei-Jun Qian, Desmond J. Smith, Richard D. Smith, Christopher C. Park, Vladislav A. Petyuk

Publikováno v: Expert Review of Proteomics. 6:243-249

Integrating quantitative proteomic and transcriptomic datasets promises valuable insights in unraveling the molecular mechanisms of the brain. We concentrate on recent studies using mass spectrometry and microarray data to investigate transcript and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07c0bf810aa602040b77dda817f278ce
https://doi.org/10.1586/epr.09.46

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Synthetic Lethality of Retinoblastoma Mutant Cells in the Drosophila Eye by Mutation of a Novel Peptidyl Prolyl Isomerase Gene

Publikováno v: Genetics. 170:161-171

Mutations that inactivate the retinoblastoma (Rb) pathway are common in human tumors. Such mutations promote tumor growth by deregulating the G1 cell cycle checkpoint. However, uncontrolled cell cycle progression can also produce new liabilities for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65091c5d6b43aa177e96872e9a4ef058
https://doi.org/10.1534/genetics.104.036343

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Effects of genome-wide copy number variation on expression in mammalian cells

Autor: Arshad H. Khan, Desmond J. Smith, Christopher C. Park, Richard T. Wang, Sangtae Ahn, Kenneth Lange

Publikováno v: BMC Genomics, Vol 12, Iss 1, p 562 (2011)
Wang, RT; Ahn, S; Park, CC; Khan, AH; Lange, K; & Smith, DJ. (2011). Effects of genome-wide copy number variation on expression in mammalian cells. BMC Genomics, 12. doi: 10.1186/1471-2164-12-562. UCLA: Retrieved from: http://www.escholarship.org/uc/item/08r1570v
BMC Genomics
Wang, Richard T; Ahn, Sangtae; Park, Christopher C; Khan, Arshad H; Lange, Kenneth; & Smith, Desmond J. (2011). Effects of genome-wide copy number variation on expression in mammalian cells. BMC Genomics, 12(1), 562. doi: http://dx.doi.org/10.1186/1471-2164-12-562. Retrieved from: http://www.escholarship.org/uc/item/63w6q0rd

Background There is only a limited understanding of the relation between copy number and expression for mammalian genes. We fine mapped cis and trans regulatory loci due to copy number change for essentially all genes using a human-hamster radiation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::272ffea32f3574e9d6b7afeec695e5e1
http://www.biomedcentral.com/1471-2164/12/562

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Comparative Analysis of Proteome and Transcriptome Variation in Mouse

Publikováno v: PLoS Genetics
Ghazalpour, A; Bennett, B; Petyuk, VA; Orozco, L; Hagopian, R; Mungrue, IN; et al.(2011). Comparative analysis of proteome and transcriptome variation in mouse. PLoS Genetics, 7(6). doi: 10.1371/journal.pgen.1001393. UCLA: Retrieved from: http://www.escholarship.org/uc/item/3qp1p825
PLoS Genetics, Vol 7, Iss 6, p e1001393 (2011)

The relationships between the levels of transcripts and the levels of the proteins they encode have not been examined comprehensively in mammals, although previous work in plants and yeast suggest a surprisingly modest correlation. We have examined t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1864c7edfc637ba48dc19b2fb33d7a8
http://europepmc.org/articles/PMC3111477

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Gene networks associated with conditional fear in mice identified using a systems genetics approach

Autor: Brian J. Bennett, Simone de Jong, Arshad H. Khan, Roel A. Ophoff, Aldons J. Lusis, Christopher C. Park, Anatole Ghazalpour, Eleazar Eskin, Steve Horvath, Greg D. Gale, Charles R. Farber, Andy Lin, Desmond J. Smith, Peter Langfelder

Publikováno v: Park, Christopher C; Gale, Greg D; de Jong, Simone; Ghazalpour, Anatole; Bennett, Brian J; Farber, Charles R; et al.(2011). Gene networks associated with conditional fear in mice identified using a systems genetics approach. BMC Systems Biology, 5(1), 43. doi: http://dx.doi.org/10.1186/1752-0509-5-43. Retrieved from: http://www.escholarship.org/uc/item/2tb981tf
BMC Systems Biology, Vol 5, Iss 1, p 43 (2011)
Park, CC; Gale, GD; de Jong, S; Ghazalpour, A; Bennett, BJ; Farber, CR; et al.(2011). Gene networks associated with conditional fear in mice identified using a systems genetics approach. BMC Systems Biology, 5. doi: 10.1186/1752-0509-5-43. UCLA: Retrieved from: http://www.escholarship.org/uc/item/7857k7sm
BMC Systems Biology

Background Our understanding of the genetic basis of learning and memory remains shrouded in mystery. To explore the genetic networks governing the biology of conditional fear, we used a systems genetics approach to analyze a hybrid mouse diversity p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d68a24472df671055d4b7e4f14e6358b
http://www.escholarship.org/uc/item/2tb981tf

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