Dietary Vitamin D and Its Metabolites Non-Genomically Stabilize the Endothelium.

Autor: Christopher C Gibson, Chadwick T Davis, Weiquan Zhu, Jay A Bowman-Kirigin, Ashley E Walker, Zhengfu Tai, Kirk R Thomas, Anthony J Donato, Lisa A Lesniewski, Dean Y Li

Publikováno v: PLoS ONE, Vol 10, Iss 10, p e0140370 (2015)

Vitamin D is a known modulator of inflammation. Native dietary vitamin D3 is thought to be bio-inactive, and beneficial vitamin D3 effects are thought to be largely mediated by the metabolite 1,25(OH)2D3. Reduced serum levels of the most commonly mea

Externí odkaz: https://doaj.org/article/e8790ceb20744644be7a87d0c72576e4

Functional immune mapping with deep-learning enabled phenomics applied to immunomodulatory and COVID-19 drug discovery

Autor: Yolanda T. Chong, Vlad Rodic, Fiona L. Weathersby, Carl A. Brooks, Michael F. Cuccarese, Nathan H. Lazar, Ian K. Quigley, Christopher C. Gibson, Ronald W. Alfa, Berton A. Earnshaw, Kirk R. Thomas, Michael A. Statnick, Brandon L. Probst, Ben Fogelson, Nicholas D. Campbell, Jes Ford, Kathleen-Rose Skelly, Mason L. Victors, Seth W. Glazier, Peter F. McLean, James D. Jensen, Imran S. Haque, Anne E. Carpenter, Sharath S. Hegde, Chadwick T. Davis, Katie Heiser, Pamela Jacobson, Brandon M. Mendivil, Adeline S. Low, Joseph Carpenter, Elissa D. Pastuzyn, Hannah B. Gordon

Development of accurate disease models and discovery of immune-modulating drugs is challenged by the immune system’s highly interconnected and context-dependent nature. Here we apply deep-learning-driven analysis of cellular morphology to develop a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f9c21782616d4199bcf88ffc3650d4b4
https://doi.org/10.1101/2020.08.02.233064

Discovery of a pre-cataclysmic binary with unusual chromaticity of the eclipsed white dwarf by the GPX survey

Autor: Varvara Brazhko, Emmanuel Jehin, Fabio Salvaggio, E. A. Antokhina, A. Burdanov, Igor I. Antokhin, Riccardo Papini, Alan Fitzsimmons, V. Krushinsky, Zouhair Benkhaldoun, Christopher C. Gibson, Khalid Barkaoui, Özgür Baştürk, Alessandro Marchini, Paul Benni, Michaël Gillon, A. A. Popov

Publikováno v: Mon. Not. R. Astron. Soc.
Monthly Notices of the Royal Astronomical Society
Krushinsky, V, Benni, P, Burdanov, A, Antokhin, I, Antokhina, E, Jehin, E, Barkaoui, K, Fitzsimmons, A, Gibson, C, Gillon, M, Popov, A, Baştürk, Ö, Benkhaldoun, Z, Marchini, A, Papini, R, Salvaggio, F & Brazhko, V 2020, ' Discovery of a pre-cataclysmic binary with unusual chromaticity of the eclipsed white dwarf by the GPX survey ', Monthly Notices of the Royal Astronomical Society, vol. 493, no. 4, pp. 5208-5217 . https://doi.org/10.1093/mnras/staa547

We report the discovery of a relatively bright eclipsing binary system, which consists of a white dwarf and a main sequence K7 star with clear signs of chromospheric and spot activity. The light curve of this system shows $\sim0.2$mag ellipsoidal var

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::135755422cacae71b664242e8ce39852
https://pureadmin.qub.ac.uk/ws/files/225703098/2002_1_.08031.pdf

Intravitreal AAV2.COMP-Ang1 Prevents Neurovascular Degeneration in a Murine Model of Diabetic Retinopathy

Autor: Judd Cahoon, Dean Y. Li, David Krizaj, Bonnie Archer, Xiaohui Zhang, Subtrata K. Das, Christopher C. Gibson, Wyatt B. Messenger, Reinhold J. Medina, Paul R. Olson, Guangping Gao, Kortnie Walker, Ruju R. Rai, Spencer Nielson, Santosh Kumar Muddana, Peter Barabas, Balamurali K. Ambati, Alan W. Stitt, Lara S Carroll, Christina L. O’Neil, Gou Y. Koh, Maggie Marie Flood, Hironori Uehara

Publikováno v: Diabetes

Diabetic retinopathy (DR) is the leading cause of blindness in the working-age population in the U.S. The vision-threatening processes of neuroglial and vascular dysfunction in DR occur in concert, driven by hyperglycemia and propelled by a pathway o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4d0c2aa257c5b74abd56172ebbd739f
https://doi.org/10.2337/db14-1030

The interplay of cyclic stretch and vascular endothelial growth factor in regulating the initial steps for angiogenesis

Autor: Li Li, Christopher C. Gibson, Daniel B. Pike, Yan-Ting Shiu, Justin R. Wilkins

Publikováno v: Biotechnology Progress. 31:248-257

Angiogenesis is regulated by chemical and mechanical factors in vivo. The regulatory role of mechanical factors and how chemical and mechanical angiogenic regulators work in concert remains to be explored. We investigated the effect of cyclic uniaxia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eea246450e6756c9fea312e17b76b48
https://doi.org/10.1002/btpr.2017