Zobrazeno 1 - 10
of 110
pro vyhledávání: '"Christopher C Coss"'
Autor:
Sophia G Liva, Yu‐Chou Tseng, Anees M Dauki, Michael G Sovic, Trang Vu, Sally E Henderson, Yi‐Chiu Kuo, Jason A Benedict, Xiaoli Zhang, Bryan C Remaily, Samuel K Kulp, Moray Campbell, Tanios Bekaii‐Saab, Mitchell A Phelps, Ching‐Shih Chen, Christopher C Coss
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 2, Pp n/a-n/a (2020)
Abstract No approved therapy exists for cancer‐associated cachexia. The colon‐26 mouse model of cancer cachexia mimics recent late‐stage clinical failures of anabolic anti‐cachexia therapy and was unresponsive to anabolic doses of diverse and
Externí odkaz:
https://doaj.org/article/e590447d2f534e9b86dfa986d39f3eb8
Autor:
Peter Y Yu, Heather L Gardner, Ryan Roberts, Hakan Cam, Seethalakshmi Hariharan, Ling Ren, Amy K LeBlanc, Hui Xiao, Jiayuh Lin, Denis C Guttridge, Xiaokui Mo, Chad E Bennett, Christopher C Coss, Yonghua Ling, Mitch A Phelps, Peter Houghton, Cheryl A London
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0181885 (2017)
STAT3 is a transcription factor involved in cytokine and receptor kinase signal transduction that is aberrantly activated in a variety of sarcomas, promoting metastasis and chemotherapy resistance. The purpose of this work was to develop and test a n
Externí odkaz:
https://doaj.org/article/1e0e13539a7340a3a783709d729e834f
Publikováno v:
Asian Journal of Andrology, Vol 16, Iss 2, Pp 256-261 (2014)
Several testosterone preparations are used in the treatment of hypogonadism in the ageing male. These therapies differ in their convenience, flexibility, regional availability and expense but share their pharmacokinetic basis of approval and dearth o
Externí odkaz:
https://doaj.org/article/cb7a209083cf49388d5dbc9bca43efe1
Autor:
Bonnie K Harrington, Heather L Gardner, Raquel Izumi, Ahmed Hamdy, Wayne Rothbaum, Kevin R Coombes, Todd Covey, Allard Kaptein, Michael Gulrajani, Bart Van Lith, Cecile Krejsa, Christopher C Coss, Duncan S Russell, Xiaoli Zhang, Bridget K Urie, Cheryl A London, John C Byrd, Amy J Johnson, William C Kisseberth
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0159607 (2016)
Acalabrutinib (ACP-196) is a second-generation inhibitor of Bruton agammaglobulinemia tyrosine kinase (BTK) with increased target selectivity and potency compared to ibrutinib. In this study, we evaluated acalabrutinib in spontaneously occurring cani
Externí odkaz:
https://doaj.org/article/885fb92964b3445a99b5a10f0adb8206
Autor:
Ramesh Narayanan, Muralimohan Yepuru, Christopher C Coss, Zhongzhi Wu, Matthew N Bauler, Christina M Barrett, Michael L Mohler, Yun Wang, Juhyun Kim, Linda M Snyder, Yali He, Nelson Levy, Duane D Miller, James T Dalton
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e83380 (2013)
Receptor tyrosine kinases (RTKs), in response to their growth factor ligands, phosphorylate and activate downstream signals important for physiological development and pathological transformation. Increased expression, activating mutations and rearra
Externí odkaz:
https://doaj.org/article/99a4bb75c3cc4be7b28f17e6807eb989
Autor:
Trang T. Vu, Kyeongmin Kim, Millennium Manna, Justin Thomas, Bryan C. Remaily, Emma J. Montgomery, Travis Costa, Lauren Granchie, Zhiliang Xie, Yizhen Guo, Min Chen, Alyssa Marie M. Castillo, Samuel K. Kulp, Xiaokui Mo, Sridhar Nimmagadda, Paul Gregorevic, Dwight H. Owen, Latha P. Ganesan, Thomas A. Mace, Christopher C. Coss, Mitch A. Phelps
Publikováno v:
Pharmacological Research, Vol 199, Iss , Pp 107048- (2024)
High baseline clearance of immune checkpoint inhibitors (ICIs), independent of dose or systemic exposure, is associated with cachexia and poor outcomes in cancer patients. Mechanisms linking ICI clearance, cachexia and ICI therapy failure are unknown
Externí odkaz:
https://doaj.org/article/2e67e650671f4d189b77c2eafc481db4
Autor:
Justin Thomas, Molly A. Torok, Kriti Agrawal, Timothy Pfau, Trang T. Vu, Justin Lyberger, Hsiaochi Chang, Alyssa Marie M. Castillo, Min Chen, Bryan Remaily, Kyeongmin Kim, Zhiliang Xie, Mary E. Dillhoff, Samuel K. Kulp, Gregory K. Behbehani, Zobeida Cruz-Monserrate, Latha P. Ganesan, Dwight H. Owen, Mitch A. Phelps, Christopher C. Coss, Thomas A. Mace
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 13, p 7066 (2022)
The neonatal Fc receptor (FcRn) is responsible for recycling of IgG antibodies and albumin throughout the body. This mechanism has been exploited for pharmaceutic delivery across an array of diseases to either enhance or diminish this function. Monoc
Externí odkaz:
https://doaj.org/article/f0f5d16c774d4cad947053189266bdaf
Autor:
Christopher C. Coss, Jeffrey T. Patrick, Damien Gerald, Gerard Hilinski, Reena Shakya, John C. Byrd
Publikováno v:
Holland‐Frei Cancer Medicine. :1-9
Autor:
Joanna E. Burdette, James R. Fuchs, Leslie N. Aldrich, Mitch A. Phelps, Xiaoli Zhang, A. Douglas Kinghorn, Steven M. Swanson, Hongyan Wang, Salane King, Christopher C. Coss, Shamalatha Kolli, Sarmistha Mazumder, Daniel D. Lantvit, Melissa A. Korkmaz, Andrew C. Huntsman, Denisse Herrera, Alexandria N. Young
SF1: Synthesis & characterization of PHYs, SF2: Purity of PHYs, SF3: PHY34 cytotoxicity in various cancer types, SF4: Additional in vivo data, SF5: PHY25 & 30 cytotoxicity time course.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4414ea5e9f72b816d205eb53b72b7ebd
https://doi.org/10.1158/1535-7163.22504809
https://doi.org/10.1158/1535-7163.22504809
Autor:
Joanna E. Burdette, James R. Fuchs, Leslie N. Aldrich, Mitch A. Phelps, Xiaoli Zhang, A. Douglas Kinghorn, Steven M. Swanson, Hongyan Wang, Salane King, Christopher C. Coss, Shamalatha Kolli, Sarmistha Mazumder, Daniel D. Lantvit, Melissa A. Korkmaz, Andrew C. Huntsman, Denisse Herrera, Alexandria N. Young
High-grade serous ovarian cancer (HGSOC) is a lethal gynecological malignancy with a need for new therapeutics. Many of the most widely used chemotherapeutic drugs are derived from natural products or their semi-synthetic derivatives. We have develop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::edfc145fe4413a848e2a021faf5379ce
https://doi.org/10.1158/1535-7163.c.6537858.v1
https://doi.org/10.1158/1535-7163.c.6537858.v1