Zobrazeno 1 - 10
of 331
pro vyhledávání: '"Christopher C, Williams"'
Autor:
Channing J. Paller, Erich P. Huang, Thomas Luechtefeld, Holly A. Massett, Christopher C. Williams, Jinxiu Zhao, Amy E. Gravell, Tami Tamashiro, Steven A. Reeves, Gary L. Rosner, Michael A. Carducci, Lawrence Rubinstein, S. Percy Ivy
Publikováno v:
Frontiers in Medicine, Vol 6 (2019)
Experimental therapeutic oncology agents are often combined to circumvent tumor resistance to individual agents. However, most combination trials fail to demonstrate sufficient safety and efficacy to advance to a later phase. This study collected sur
Externí odkaz:
https://doaj.org/article/cd7815f522cd4ad1b572ff59f04dc918
Autor:
Philip Jones, Nancy E. Kohl, Timothy P. Heffernan, Joseph R. Marszalek, Giulio F. Draetta, Andy M. Zuniga, Simon S. Yu, Christopher C. Williams, Erika Suzuki, Nakia D. Spencer, Sahil Seth, Vandhana Ramamoorthy, Michael Peoples, Robert A. Mullinax, Meredith A. Miller, Timothy McAfoos, Pijus K. Mandal, Xiaoyan Ma, Anastasia M. Lopez, Chiu-Yi Liu, Jeffrey J. Kovacs, Zhijun Kang, Yongying Jiang, Justin K. Huang, Virginia Giuliani, Sonal Gera, Guang Gao, Ningping Feng, Qing Chang, Christopher L. Carroll, Caroline C. Carrillo, Jason P. Burke, Christopher A. Bristow, Benjamin J. Bivona, Maria Emilia Di Francesco, Jason B. Cross, Connor A. Parker, Sarah Johnson, Qi Wu, Angela L. Harris, Faika Mseeh, Paul Leonard, Barbara Czako, Brooke A. Meyers, Yuting Sun
Src homology 2 domain-containing phosphatase (SHP2) is a phosphatase that mediates signaling downstream of multiple receptor tyrosine kinases (RTK) and is required for full activation of the MAPK pathway. SHP2 inhibition has demonstrated tumor growth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::679aa5c2787960118aa25b0d20d0a771
https://doi.org/10.1158/0008-5472.c.6512119.v1
https://doi.org/10.1158/0008-5472.c.6512119.v1
Autor:
Nancy E. Kohl, Zhijun Kang, Connor A. Parker, Yuting Sun, Yongying Jiang, Simon S. Yu, Cross Jason, Ningping Feng, Faika Mseeh, Timothy McAfoos, Maria Emilia Di Francesco, Timothy P. Heffernan, Angela L. Harris, Brooke A. Meyers, Paul G. Leonard, Joseph R. Marszalek, Christopher C. Williams, Qi Wu, Jeffrey J. Kovacs, Pijus K. Mandal, Jason P Burke, Giulio Draetta, Barbara Czako, Philip Jones, Christopher Carroll
Publikováno v:
Journal of Medicinal Chemistry. 64:15141-15169
Src homology 2 (SH2) domain-containing phosphatase 2 (SHP2) plays a role in receptor tyrosine kinase (RTK), neurofibromin-1 (NF-1), and Kirsten rat sarcoma virus (KRAS) mutant-driven cancers, as well as in RTK-mediated resistance, making the identifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::52237ec958405671436618b3a028bf48
https://doi.org/10.1021/acs.jmedchem.1c01132
https://doi.org/10.1021/acs.jmedchem.1c01132
Autor:
Sarah A. Mosure, Paola Munoz-Tello, Kuang-Ting Kuo, Brian MacTavish, Xiaoyu Yu, Daniel Scholl, Christopher C. Williams, Timothy S. Strutzenberg, Jared Bass, Richard Brust, Ashok A. Deniz, Patrick R. Griffin, Douglas J. Kojetin
PPARγ is a nuclear receptor transcription factor that regulates adipogenic and insulin sensitizing gene programs via two activation function (AF) regulatory domains: a ligand-dependent AF-2 coregulator interaction surface within the C-terminal ligan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1391d8be19b46ea8fd2251bbc5a88fd
https://doi.org/10.1101/2022.07.13.499031
https://doi.org/10.1101/2022.07.13.499031
Autor:
Jonathan D. Shapiro, Justin C. Sonberg, Benjamin C. Schafer, Christopher C. Williams, Hannah R. Ferris, Eric W. Reinheimer, Adam W. Van Wynsberghe, Charles E. Kriley, Max M. Majireck
Publikováno v:
Molecules, Vol 23, Iss 2, p 413 (2018)
N-Substituted pyridinium salts constitute one of the most valuable reagent classes in organic synthesis, due to their versatility and ease of use. Herein we report a preliminary synthesis and detailed structural analysis of several N-(1-ethoxyvinyl)p
Externí odkaz:
https://doaj.org/article/111050e0c7124d2c9e11e1e317675111
Autor:
Barbara, Czako, Yuting, Sun, Timothy, McAfoos, Jason B, Cross, Paul G, Leonard, Jason P, Burke, Christopher L, Carroll, Ningping, Feng, Angela L, Harris, Yongying, Jiang, Zhijun, Kang, Jeffrey J, Kovacs, Pijus, Mandal, Brooke A, Meyers, Faika, Mseeh, Connor A, Parker, Simon S, Yu, Christopher C, Williams, Qi, Wu, Maria Emilia, Di Francesco, Giulio, Draetta, Timothy, Heffernan, Joseph R, Marszalek, Nancy E, Kohl, Philip, Jones
Publikováno v:
Journal of medicinal chemistry. 64(20)
Src homology 2 (SH2) domain-containing phosphatase 2 (SHP2) plays a role in receptor tyrosine kinase (RTK), neurofibromin-1 (NF-1), and Kirsten rat sarcoma virus (KRAS) mutant-driven cancers, as well as in RTK-mediated resistance, making the identifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ef1c5b3d344a33f3d6564080b26ff7f2
https://pubmed.ncbi.nlm.nih.gov/34643390
https://pubmed.ncbi.nlm.nih.gov/34643390
Autor:
Caroline F. Sullivan, Isabella C. Bote, Jonathan D. Shapiro, Benjamin C. Schafer, Olivia M. Simone, Sofia Rachad, Justin C. Sonberg, Yasin A. Haffary, Christopher C. Williams, Caitlin E. Anthony, Phoebe V. Keyes, Alisha M. Blades, Holly L. Hutchinson, Danielle Gomes Rodrigues, Ashley B. Thayaparan, Sambat Bhandari, Jack A. Goodman, Danielle L. McConnell, Zoe A. Krevlin, Max M. Majireck, Amy M. Glanzer
N-Quaternized ketene N,O-acetals are typically an unstable, transient class of compounds most commonly observed as reactive intermediates. In this report, we describe a general synthetic approach to a variety of bench-stable N-quaternized ketene N,O-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d1a922b12bbe8e54ed7b03063b1d8d0
https://doi.org/10.33774/chemrxiv-2021-5n593-v2
https://doi.org/10.33774/chemrxiv-2021-5n593-v2
Autor:
Jessica L. Childs-Disney, Samantha M. Meyer, Yuquan Tong, Jessica A. Bush, Christopher C. Williams, Matthew D. Disney, Hafeez S. Haniff
Publikováno v:
ACS Chem Biol
The interrogation and manipulation of biological systems by small molecules is a powerful approach in chemical biology. Ideal compounds selectively engage a target and mediate a downstream phenotypic response. Although historically small molecule dru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::410dfdcb0bae07ca046d9df27457468f
https://pubmed.ncbi.nlm.nih.gov/34166593
https://pubmed.ncbi.nlm.nih.gov/34166593
Autor:
Hafeez S. Haniff, Jake Peterson, Walter N. Moss, Ryan J. Andrews, Collin A. O’Leary, Christopher C. Williams, Van S. Tompkins, Matthew D. Disney
Publikováno v:
NAR Genomics and Bioinformatics. 3
SARS-CoV-2 has exploded throughout the human population. To facilitate efforts to gain insights into SARS-CoV-2 biology and to target the virus therapeutically, it is essential to have a roadmap of likely functional regions embedded in its RNA genome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66e3c76a5951ce134e8f3104f70e3a58
https://doi.org/10.1093/nargab/lqab043
https://doi.org/10.1093/nargab/lqab043
Autor:
Yoshihiro Akahori, Jessica L. Childs-Disney, Toru Tanaka, Christopher C. Williams, Samantha M. Meyer, Haruo Aikawa, Matthew D. Disney, Yuquan Tong
Publikováno v:
Chem Soc Rev
Targeting RNAs with small molecules represents a new frontier in drug discovery and development. The rich structural diversity of folded RNAs offers a nearly unlimited reservoir of targets for small molecules to bind, similar to small molecule occupa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ee6fed747a971c6ef1f36510d087fe9
https://pubmed.ncbi.nlm.nih.gov/32975549
https://pubmed.ncbi.nlm.nih.gov/32975549