Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Christopher C, Wendler"'
Publikováno v:
FEBS Open Bio, Vol 11, Iss 8, Pp 2364-2382 (2021)
We previously found that DNA methyltransferase 3a (DNMT3a) plays an important role in regulating embryonic cardiomyocyte gene expression, morphology, and function. In this study, we investigated the role of the most abundant DNMT in mammalian cells,
Externí odkaz:
https://doaj.org/article/66be8a155d704192813463ad529cae02
Autor:
Daniela L Buscariollo, Xiefan Fang, Victoria Greenwood, Huiling Xue, Scott A Rivkees, Christopher C Wendler
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e87547 (2014)
Evidence indicates that disruption of normal prenatal development influences an individual's risk of developing obesity and cardiovascular disease as an adult. Thus, understanding how in utero exposure to chemical agents leads to increased susceptibi
Externí odkaz:
https://doaj.org/article/6480dc0b142c4e3aac407bc531fc2193
Publikováno v:
Section on Neonatal-Perinatal Medicine Program.
Purpose: Up to 30% of low birth weight preterm infants manifest some form of periventricular white matter injury (PWMI) making it the most common form of brain injury affecting premature infants. It is believed that loss of oligodendrocyte progenitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f03bc0a05aedfecc379de799214e76bb
https://doi.org/10.1542/peds.147.3_meetingabstract.756
https://doi.org/10.1542/peds.147.3_meetingabstract.756
Autor:
Valeria C Benavides, Murali K Mallela, Carmen J Booth, Christopher C Wendler, Scott A Rivkees
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e35213 (2012)
Hyperthyroidism during pregnancy is treated with the antithyroid drugs (ATD) propylthiouracil (PTU) and methimazole (MMI). PTU currently is recommended as the drug of choice during early pregnancy. Yet, despite widespread ATD use in pregnancy, formal
Externí odkaz:
https://doaj.org/article/8e398444428343ba9e5e081515650d78
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e28296 (2011)
Evidence suggests that adenosine acts via cardiac A1 adenosine receptors (A1ARs) to protect embryos against hypoxia. During embryogenesis, A1ARs are the dominant regulator of heart rate, and A1AR activation reduces heart rate. Adenosine action is inh
Externí odkaz:
https://doaj.org/article/489842cc7c424f51a5758fd912335c2f
Publikováno v:
The FASEB Journal. 33
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c64afdd4df9de81d543ab41d482219d
https://doi.org/10.1096/fasebj.2019.33.1_supplement.lb169
https://doi.org/10.1096/fasebj.2019.33.1_supplement.lb169
Autor:
Jourdon Robinson, Xiefan Fang, Daniel Freeman, John Wang-Hu, Christopher C. Wendler, Lingli Jiang, Scott A. Rivkees
Publikováno v:
American Journal of Physiology-Cell Physiology. 309:C425-C436
cAMP is a highly regulated secondary messenger involved in many biological processes. Chronic activation of the cAMP pathway by catecholamines results in cardiac hypertrophy and fibrosis; however, the mechanism by which elevated cAMP leads to cardiom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecc2921c8059d874a16aaeb61b4d4b8a
https://doi.org/10.1152/ajpcell.00058.2015
https://doi.org/10.1152/ajpcell.00058.2015
There is growing evidence that disruption in the prenatal environment can have long-lasting effects on an individual's health in adulthood. Research on the fetal programming of adult diseases, including cardiovascular disease, focuses on epi-mutation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81d43292107f8a4bcf1a33db55521884
https://europepmc.org/articles/PMC5487283/
https://europepmc.org/articles/PMC5487283/
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 307:R1471-R1487
Previous studies demonstrated that in utero caffeine treatment at embryonic day (E) 8.5 alters DNA methylation patterns, gene expression, and cardiac function in adult mice. To provide insight into the mechanisms, we examined cardiac gene and microRN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::435c1068ce284d0d4e65f156d267500d
https://doi.org/10.1152/ajpregu.00307.2014
https://doi.org/10.1152/ajpregu.00307.2014
Publikováno v:
Brain Research. 1586:64-72
Periventricular white matter injury (PWMI) is the most common cause of brain injury in preterm infants. It is believed that loss of late oligodendrocyte progenitor cells (OPCs) and disrupted maturation of oligodendrocytes contributes to defective mye
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0529f328f92dbf562fbafae4a6074441
https://doi.org/10.1016/j.brainres.2014.08.046
https://doi.org/10.1016/j.brainres.2014.08.046