Výsledky vyhledávání - "Christopher C, Presley"

Synthesis and characterization of chiral 6-azaspiro[2.5]octanes as potent and selective antagonists of the M

Autor: Aaron M, Bender, Trever R, Carter, Matthew, Spock, Alice L, Rodriguez, Jonathan W, Dickerson, Jerri M, Rook, Sichen, Chang, Aidong, Qi, Christopher C, Presley, Darren W, Engers, Joel M, Harp, Thomas M, Bridges, Colleen M, Niswender, P Jeffrey, Conn, Craig W, Lindsley

Publikováno v: Bioorganicmedicinal chemistry letters. 56

In this manuscript, we report a series of chiral 6-azaspiro[2.5]octanes and related spirocycles as highly potent and selective antagonists of the muscarinic acetylcholine receptor subtype 4 (mAChR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::15d71c45fc9259c6cf1b62b08759c9b1
https://pubmed.ncbi.nlm.nih.gov/34838649

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Evaluation of Synthetic Cytochrome P450-Mimetic Metalloporphyrins To Facilitate 'Biomimetic' Biotransformation of a Series of mGlu5 Allosteric Ligands

Autor: Colleen M. Niswender, Christopher C Presley, P. Jeffrey Conn, Vincent B. Luscombe, Alice L. Rodriguez, Charles K. Perry, Craig W. Lindsley, Matthew J. Mulder, Elizabeth S. Childress

Publikováno v: ACS Omega, Vol 4, Iss 7, Pp 12782-12789 (2019)

Allosteric ligands within a given chemotype can have the propensity to display a wide range of pharmacology, as well as unexpected changes in GPCR subtype selectivity, typically mediated by single-atom modifications to the ligand. Due to the unexpect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d507940bc2a7cff2b1f11bcdaff15da0
https://doi.org/10.1021/acsomega.9b02017

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Synthesis and characterization of chiral 6-azaspiro[2.5]octanes as potent and selective antagonists of the M4 muscarinic acetylcholine receptor

Autor: Jerri M. Rook, P. Jeffrey Conn, Aidong Qi, Aaron M. Bender, Matthew Spock, Colleen M. Niswender, Thomas M. Bridges, Sichen Chang, Trever R Carter, Craig W. Lindsley, Joel M. Harp, Christopher C Presley, Alice L. Rodriguez, Darren W. Engers, Jonathan W. Dickerson

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 56:128479

In this manuscript, we report a series of chiral 6-azaspiro[2.5]octanes and related spirocycles as highly potent and selective antagonists of the muscarinic acetylcholine receptor subtype 4 (mAChR4). Chiral separation and subsequent X-ray crystallogr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8e9bcf50b4cdb04cbbd84852b4ecd42f
https://doi.org/10.1016/j.bmcl.2021.128479

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New potently bioactive alkaloids from Crinum erubescens

Autor: Priscilla Krai, Seema Dalal, David G. I. Kingston, Maria B. Cassera, Michael Goetz, Qingxi Su, Christopher C. Presley

Publikováno v: Bioorganic & Medicinal Chemistry. 24:5418-5422

Antimalarial bioassay-guided fractionation of the swamp lily Crinum erubescens led to the isolation of four compounds with potent antiplasmodial activity. Compounds 1 and 2 were determined from their spectroscopic data to be the known pesticidal comp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0374de72339b41d0d93a2f8eb24922db
https://doi.org/10.1016/j.bmc.2016.08.058

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Antiplasmodial Chromanes and Chromenes from the Monotypic Plant Species Koeberlinia spinosa

Autor: Maria L. Fernández-Murga, Jason A. Clement, Yongle Du, Ana Lisa Valenciano, David G. I. Kingston, Narasimhamurthy Shanaiah, Christopher C. Presley, Maria B. Cassera, Michael Goetz

Publikováno v: Journal of natural products. 81(3)

Nine new compounds containing either a chromane or chromene ring moiety were isolated from the monotypic plant Koeberlinia spinosa. Compounds 1 – 4 are chromanes with all possible E and Z isomers of the isoprenoid side chain, with compound 5 a meth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ee5eba3d76ccab0b5346aa299cf8380
https://pubmed.ncbi.nlm.nih.gov/29048892

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Isolation, structure elucidation, and synthesis of antiplasmodial quinolones from Crinum firmifolium

Autor: Stephan Rakotonandrasana, Seema Dalal, David G. I. Kingston, Christopher C. Presley, Vincent E. Rasamison, Yongle Du, Emilio F. Merino, Maria B. Cassera, Joshua H. Butler

Antiplasmodial bioassay guided fractionation of a Madagascar collection of Crinum firmifolium led to the isolation of seven compounds. Five of the seven compounds were determined to be 2-alkylquinolin-4(1H)-ones with varying side chains. Compounds 1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf99db24c4bddc862e5772ee21d1d16f
https://europepmc.org/articles/PMC5557408/

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A Synthetic Butenolide Diterpene is now a Natural Product Isolated from Metaporana sericosepala, a Plant from the Madagascar Dry Forest

Autor: Christopher C, Presley, L Harinantenaina, Rakotondraibe, Peggy J, Brodie, Martin W, Callmander, Richard, Randrianaivo, Vincent E, Rasamison, Etienne, Rakotobe, David G I, Kingston

Publikováno v: Natural product communications. 10(9)

Antiproliferative bioassay-guided fractionation of the ethanolic extract of the endemic Madagascan plant Metaporana sericosepala led to the first natural product isolation of a butenolide diterpene, which was synthesized during an anti-inflammatory s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::237d9a90c78c1f6497b70e47108cedbd
https://pubmed.ncbi.nlm.nih.gov/26435765

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