Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Christopher C, Frye"'
Autor:
Laura Bryan, Michael Henry, Ronan M. Kelly, Christopher C. Frye, Matthew D. Osborne, Martin Clynes, Paula Meleady
Publikováno v:
BMC Biotechnology, Vol 21, Iss 1, Pp 1-21 (2021)
Abstract Background The ability to achieve high peak viable cell density earlier in CHO cell culture and maintain an extended cell viability throughout the production process is highly desirable to increase recombinant protein yields, reduce host cel
Externí odkaz:
https://doaj.org/article/2c0f82402ee7444596300a1ca0795729
Autor:
Laura Bryan, Michael Henry, Ronan M. Kelly, Michael Lloyd, Christopher C. Frye, Matthew D. Osborne, Martin Clynes, Paula Meleady
Publikováno v:
Current Research in Biotechnology, Vol 3, Iss , Pp 49-56 (2021)
Understanding the biology of CHO cells at a cellular level is extremely valuable to the pharmaceutical industry, as it presents the opportunity to rationally engineer clonally derived cell lines (CDCLs) with elevated recombinant specific productivity
Externí odkaz:
https://doaj.org/article/577b1f6cdaaf44fe9f8ca25ad5e49c52
Autor:
Matthew D. Osborne, Ronan M. Kelly, Martin Clynes, Christopher C. Frye, Michael Henry, Michael E. Lloyd, Laura Bryan, Paula Meleady
Publikováno v:
Current Research in Biotechnology, Vol 3, Iss, Pp 49-56 (2021)
Understanding the biology of CHO cells at a cellular level is extremely valuable to the pharmaceutical industry, as it presents the opportunity to rationally engineer clonally derived cell lines (CDCLs) with elevated recombinant specific productivity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c79b82f1d7683b96a0f04fa4574d724
http://www.sciencedirect.com/science/article/pii/S259026282100006X
http://www.sciencedirect.com/science/article/pii/S259026282100006X
Autor:
Michael Henry, Laura Bryan, Matthew D. Osborne, Ronan M. Kelly, Christopher C. Frye, Paula Meleady, Martin Clynes
Publikováno v:
BMC Biotechnology
BMC Biotechnology, Vol 21, Iss 1, Pp 1-21 (2021)
BMC Biotechnology, Vol 21, Iss 1, Pp 1-21 (2021)
Background The ability to achieve high peak viable cell density earlier in CHO cell culture and maintain an extended cell viability throughout the production process is highly desirable to increase recombinant protein yields, reduce host cell impurit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c94ee106dba105b6e839b2d08b4e6f8e
https://doi.org/10.1186/s12896-021-00704-8
https://doi.org/10.1186/s12896-021-00704-8
Autor:
Michael Henry, Paula Meleady, Niall Barron, Clair Gallagher, Martin Clynes, Laura Bryan, Christopher C. Frye, Matthew D. Osborne, Ronan M. Kelly
Publikováno v:
Biotechnology Letters
Objectives We used miRNA and proteomic profiling to understand intracellular pathways that contribute to high and low specific productivity (Qp) phenotypes in CHO clonally derived cell lines (CDCLs) from the same cell line generation project. Results
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::393fa236acf55412bafece999beefcca
https://pubmed.ncbi.nlm.nih.gov/34131805
https://pubmed.ncbi.nlm.nih.gov/34131805
Autor:
Ning Wang, Christopher C. Frye, Zhuo Cheng, Stephanie L. Sandefur, Michael E. Lloyd, Stephen F. Konieczny, Patrick G. Schweickert
Publikováno v:
Biotechnology journalREFERENCES. 16(4)
Most biopharmaceuticals produced today are generated using Chinese hamster ovary (CHO) cells, therefore significant attention is focused on methods to improve CHO cell productivity and product quality. The discovery of gene-editing tools, such as CRI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd81b98fa053c8e4bb2501d8ed6415f9
https://pubmed.ncbi.nlm.nih.gov/33369118
https://pubmed.ncbi.nlm.nih.gov/33369118
Autor:
Alexei Kharitonenkov, John M Beals, Radmila Micanovic, Beth A Strifler, Radhakrishnan Rathnachalam, Victor J Wroblewski, Shun Li, Anja Koester, Amy M Ford, Tamer Coskun, James D Dunbar, Christine C Cheng, Christopher C Frye, Thomas F Bumol, David E Moller
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e58575 (2013)
Fibroblast growth factor 21 is a novel hormonal regulator with the potential to treat a broad variety of metabolic abnormalities, such as type 2 diabetes, obesity, hepatic steatosis, and cardiovascular disease. Human recombinant wild type FGF21 (FGF2
Externí odkaz:
https://doaj.org/article/5847a90134ee450d8853ad80dc8fbeb7
Autor:
Courtney S. Cochancela, Christopher C. Frye, Elizabeth V. Eikey, Linda Sun, Linh G. Ly, Julissa Murrieta
Publikováno v:
Sustainable Digital Communities ISBN: 9783030436865
iConference
iConference
As social media becomes more prevalent, understanding its use and its relationship with mental health is crucial, especially among marginalized populations. Immigrant college students in the United States face unique challenges that put them at an in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe2458d9b2284e577c30a3660c954ee2
https://doi.org/10.1007/978-3-030-43687-2_11
https://doi.org/10.1007/978-3-030-43687-2_11
Autor:
Michael Henry, Paula Meleady, Martin Clynes, Christopher C. Frye, Ciaran P. Brady, Niall Barron, Clair Gallagher, Ronan M. Kelly, Matthew D. Osborne
Publikováno v:
Journal of Biotechnology. 281:21-30
Product degradation, such as clipping, is a common quality issue in the production of Fc-fusion proteins from Chinese hamster ovary (CHO) cells. Degradation of proteins is mainly due to the action of either intracellular or extracellular host cell pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d11043883c87492e496e6a45bc4006d
https://doi.org/10.1016/j.jbiotec.2018.05.018
https://doi.org/10.1016/j.jbiotec.2018.05.018
Publikováno v:
Biotechnology Progress. 34:570-583
Mammalian cell line development is critical to bioproduct manufacturing. Success requires selecting a line with desirable performance characteristics, including consistent expression throughout the proposed manufacturing window. Given the genetic and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::015109df4bf2841eacc00861201748d7
https://doi.org/10.1002/btpr.2667
https://doi.org/10.1002/btpr.2667