Výsledky vyhledávání - "Christopher C, Coss"

Akademický článek

Decoupling FcRn and tumor contributions to elevated immune checkpoint inhibitor clearance in cancer cachexia

Publikováno v: Pharmacological Research, Vol 199, Iss , Pp 107048- (2024)

High baseline clearance of immune checkpoint inhibitors (ICIs), independent of dose or systemic exposure, is associated with cachexia and poor outcomes in cancer patients. Mechanisms linking ICI clearance, cachexia and ICI therapy failure are unknown

Externí odkaz: https://doaj.org/article/2e67e650671f4d189b77c2eafc481db4

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Akademický článek

Murine cancer cachexia models replicate elevated catabolic pembrolizumab clearance in humans

Autor: Alyssa Marie M. Castillo, Trang T. Vu, Sophia G. Liva, Min Chen, Zhiliang Xie, Justin Thomas, Bryan Remaily, Yizhen Guo, Uma L. Subrayan, Travis Costa, Timothy H. Helms, Donald J. Irby, Kyeongmin Kim, Dwight H. Owen, Samuel K. Kulp, Thomas A. Mace, Mitch A. Phelps, Christopher C. Coss

Publikováno v: JCSM Rapid Communications, Vol 4, Iss 2, Pp 232-244 (2021)

Abstract Background Monoclonal antibody (mAb) immune checkpoint inhibitor (ICI) therapies have dramatically impacted oncology this past decade. However, only about one‐third of patients respond to treatment, and biomarkers to predict responders are

Externí odkaz: https://doaj.org/article/db94475297f14a02937ba2decc4f78d7

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Akademický článek

Inhibition of androgen/AR signaling inhibits diethylnitrosamine (DEN) induced tumour initiation and remodels liver immune cell networks

Autor: Timothy H. Helms, Riley D. Mullins, Jennifer M. Thomas-Ahner, Samuel K. Kulp, Moray J. Campbell, Fabienne Lucas, Nathan Schmidt, Dana M. LeMoine, Surafel Getaneh, Zhiliang Xie, Mitch A. Phelps, Steven K. Clinton, Christopher C. Coss

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)

Abstract A promotional role for androgen receptor (AR) signaling in hepatocellular carcinogenesis is emerging. In pre-clinical models, including diethylnitrosamine- (DEN-) induced hepatocellular carcinoma (HCC), anti-androgen therapies delay hepatoca

Externí odkaz: https://doaj.org/article/c25b0208e10b4d27952527a2f7974c56

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Akademický článek

Activity of Estrogen Receptor β Agonists in Therapy-Resistant Estrogen Receptor-Positive Breast Cancer

Autor: Jharna Datta, Natalie Willingham, Jasmine M. Manouchehri, Patrick Schnell, Mirisha Sheth, Joel J. David, Mahmoud Kassem, Tyler A. Wilson, Hanna S. Radomska, Christopher C. Coss, Chad E. Bennett, Ramesh K. Ganju, Sagar D. Sardesai, Maryam Lustberg, Bhuvaneswari Ramaswamy, Daniel G. Stover, Mathew A. Cherian

Publikováno v: Frontiers in Oncology, Vol 12 (2022)

BackgroundAmong women, breast cancer is the leading cause of cancer-related death worldwide. Estrogen receptor α-positive (ERα+) breast cancer accounts for 70% of all breast cancer subtypes. Although ERα+ breast cancer initially responds to estrog

Externí odkaz: https://doaj.org/article/432a0e095a4c45e2800716a4915a5e12

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Akademický článek

Overcoming resistance to anabolic SARM therapy in experimental cancer cachexia with an HDAC inhibitor

Autor: Sophia G Liva, Yu‐Chou Tseng, Anees M Dauki, Michael G Sovic, Trang Vu, Sally E Henderson, Yi‐Chiu Kuo, Jason A Benedict, Xiaoli Zhang, Bryan C Remaily, Samuel K Kulp, Moray Campbell, Tanios Bekaii‐Saab, Mitchell A Phelps, Ching‐Shih Chen, Christopher C Coss

Publikováno v: EMBO Molecular Medicine, Vol 12, Iss 2, Pp 1-21 (2020)

Abstract No approved therapy exists for cancer‐associated cachexia. The colon‐26 mouse model of cancer cachexia mimics recent late‐stage clinical failures of anabolic anti‐cachexia therapy and was unresponsive to anabolic doses of diverse and

Externí odkaz: https://doaj.org/article/e590447d2f534e9b86dfa986d39f3eb8

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