Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Christopher Buccitelli"'
Autor:
Narendra Kumar Chunduri, Paul Menges, Xiaoxiao Zhang, Angela Wieland, Vincent Leon Gotsmann, Balca R. Mardin, Christopher Buccitelli, Jan O. Korbel, Felix Willmund, Maik Kschischo, Markus Raeschle, Zuzana Storchova
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
The mechanisms that allow cancer cells to survive with monosomies are poorly understood. Here the authors analyse p53-deficient monosomic cell lines using transcriptomics and proteomics, and find that impaired ribosome biogenesis and p53 downregulati
Externí odkaz:
https://doaj.org/article/f60023c0c8584a2bac35d7bc8847a8c0
Autor:
Emanuel Wyler, Kirstin Mösbauer, Vedran Franke, Asija Diag, Lina Theresa Gottula, Roberto Arsiè, Filippos Klironomos, David Koppstein, Katja Hönzke, Salah Ayoub, Christopher Buccitelli, Karen Hoffmann, Anja Richter, Ivano Legnini, Andranik Ivanov, Tommaso Mari, Simone Del Giudice, Jan Papies, Samantha Praktiknjo, Thomas F. Meyer, Marcel Alexander Müller, Daniela Niemeyer, Andreas Hocke, Matthias Selbach, Altuna Akalin, Nikolaus Rajewsky, Christian Drosten, Markus Landthaler
Publikováno v:
iScience, Vol 24, Iss 3, Pp 102151- (2021)
Summary: Detailed knowledge of the molecular biology of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is crucial for understanding of viral replication, host responses, and disease progression. Here, we report gene expression
Externí odkaz:
https://doaj.org/article/aa494f159d1e4728b02c9632c197db4f
Autor:
Lorena Salgueiro, Christopher Buccitelli, Konstantina Rowald, Kalman Somogyi, Sridhar Kandala, Jan O Korbel, Rocio Sotillo
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 3, Pp n/a-n/a (2020)
Abstract Chromosome instability (CIN) has been associated with therapeutic resistance in many cancers. However, whether tumours become genomically unstable as an evolutionary mechanism to overcome the bottleneck exerted by therapy is not clear. Using
Externí odkaz:
https://doaj.org/article/225029ac68f7435d9344bd21f7538671
Autor:
Konstantina Rowald, Martina Mantovan, Joana Passos, Christopher Buccitelli, Balca R. Mardin, Jan O. Korbel, Martin Jechlinger, Rocio Sotillo
Publikováno v:
Cell Reports, Vol 15, Iss 12, Pp 2679-2691 (2016)
Chromosome instability (CIN) is associated with poor survival and therapeutic outcome in a number of malignancies. Despite this correlation, CIN can also lead to growth disadvantages. Here, we show that simultaneous overexpression of the mitotic chec
Externí odkaz:
https://doaj.org/article/b18daaf5285944e4bbc910a431353d51
Autor:
Leo Hansmann, Thomas Blankenstein, Klaus Dornmair, Hans-Peter Rahn, Holger Hackstein, Julian Strobel, Armin Gerbitz, Dieter Beule, Eric Blanc, Andreas Moosmann, Lars Bullinger, Kerstin Dietze, Philipp Mertins, Oliver Popp, Christopher Buccitelli, Xiaojing Chen, Livius Penter, Amin Ben Hamza, Meng-Tung Hsu, Christian Alexander Stein, María Fernanda Lammoglia Cobo, Carlotta Welters
Supplementary Data from Immune Phenotypes and Target Antigens of Clonally Expanded Bone Marrow T Cells in Treatment-Naïve Multiple Myeloma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::326688ee2fbf55de238c9000bbcc9400
https://doi.org/10.1158/2326-6066.22545401
https://doi.org/10.1158/2326-6066.22545401
Autor:
Leo Hansmann, Thomas Blankenstein, Klaus Dornmair, Hans-Peter Rahn, Holger Hackstein, Julian Strobel, Armin Gerbitz, Dieter Beule, Eric Blanc, Andreas Moosmann, Lars Bullinger, Kerstin Dietze, Philipp Mertins, Oliver Popp, Christopher Buccitelli, Xiaojing Chen, Livius Penter, Amin Ben Hamza, Meng-Tung Hsu, Christian Alexander Stein, María Fernanda Lammoglia Cobo, Carlotta Welters
Supplementary Figure from Immune Phenotypes and Target Antigens of Clonally Expanded Bone Marrow T Cells in Treatment-Naïve Multiple Myeloma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a022295c65ecfb3a28dc22817638e31d
https://doi.org/10.1158/2326-6066.22545398
https://doi.org/10.1158/2326-6066.22545398
Autor:
Leo Hansmann, Thomas Blankenstein, Klaus Dornmair, Hans-Peter Rahn, Holger Hackstein, Julian Strobel, Armin Gerbitz, Dieter Beule, Eric Blanc, Andreas Moosmann, Lars Bullinger, Kerstin Dietze, Philipp Mertins, Oliver Popp, Christopher Buccitelli, Xiaojing Chen, Livius Penter, Amin Ben Hamza, Meng-Tung Hsu, Christian Alexander Stein, María Fernanda Lammoglia Cobo, Carlotta Welters
Multiple myeloma is a hematologic malignancy of monoclonal plasma cells that accumulate in the bone marrow. Despite their clinical and pathophysiologic relevance, the roles of bone marrow–infiltrating T cells in treatment-naïve patients are incomp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad070a93cf52269f92b2f532afcb132e
https://doi.org/10.1158/2326-6066.c.6550931
https://doi.org/10.1158/2326-6066.c.6550931
Autor:
Carlotta Welters, María Fernanda Lammoglia Cobo, Christian Alexander Stein, Meng-Tung Hsu, Amin Ben Hamza, Livius Penter, Xiaojing Chen, Christopher Buccitelli, Oliver Popp, Philipp Mertins, Kerstin Dietze, Lars Bullinger, Andreas Moosmann, Eric Blanc, Dieter Beule, Armin Gerbitz, Julian Strobel, Holger Hackstein, Hans-Peter Rahn, Klaus Dornmair, Thomas Blankenstein, Leo Hansmann
Publikováno v:
Cancer immunology research. 10(11)
Multiple myeloma is a hematologic malignancy of monoclonal plasma cells that accumulate in the bone marrow. Despite their clinical and pathophysiologic relevance, the roles of bone marrow–infiltrating T cells in treatment-naïve patients are incomp
Publikováno v:
Nature Reviews Genetics. 21:630-644
Gene expression involves transcription, translation and the turnover of mRNAs and proteins. The degree to which protein abundances scale with mRNA levels and the implications in cases where this dependency breaks down remain an intensely debated topi
Autor:
Zuzana Storchova, Vincent Leon Gotsmann, Narendra Kumar Chunduri, Christopher Buccitelli, Balca R. Mardin, Raeschle M, Angela Wieland, Xiaoxiao Zhang, Maik Kschischo, Paul Menges, Jan O. Korbel, Felix Willmund
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications
Nature Communications
Chromosome loss that results in monosomy is detrimental to viability, yet it is frequently observed in cancers. How cancers survive with monosomy is unknown. Using p53-deficient monosomic cell lines, we find that chromosome loss impairs proliferation