Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Christopher Bruce Alexander Whitelaw"'
Autor:
Corinne Kostic, Simon Geoffrey Lillico, Sylvain Vincent Crippa, Nicolas Grandchamp, Héloïse Pilet, Stéphanie Philippe, Zen Lu, Tim James King, Jacques Mallet, Chamsy Sarkis, Yvan Arsenijevic, Christopher Bruce Alexander Whitelaw
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e71363 (2013)
Large animal models are an important resource for the understanding of human disease and for evaluating the applicability of new therapies to human patients. For many diseases, such as cone dystrophy, research effort is hampered by the lack of such m
Externí odkaz:
https://doaj.org/article/7784ac9227994fef97df496cab29b329
Autor:
Christopher Bruce Alexander Whitelaw, Enguang Rong, Inga Dry, Simon G. Lillico, Wenfang S. Tan, Robert G. Dalziel, Andy Law
We produced a genome wide CRISPR knockout library, btCRISPRko.v1, targeting all protein coding genes in the cattle genome and used it to identify host genes important for Bovine Herpes Virus Type 1 (BHV-1) replication. By infecting library transduced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1122245347e1b0f6e273ed97a46a3c99
https://doi.org/10.1101/2020.06.17.155788
https://doi.org/10.1101/2020.06.17.155788
Autor:
Christopher Bruce Alexander Whitelaw, Jonathan D. Cooper, Gerard Thompson, Simon G. Lillico, K. Hamer, Tim King, Paul A. Skehel, E. Clutton, Sally L. Eaton, Christopher Proudfoot, Rachel A. Kline, Nina Marie Rzechorzek, Rachael Gregson, Charles A. O'Neill, Thomas M. Wishart
Publikováno v:
Eaton, S, Proudfoot, C, Lillico, S, Skehel, P, Kline, R, Hamer, K, Rzechorzek, N, Clutton, R, Gregson, R, King, T, O'Neill, C A, Cooper, J D, Thompson, G, Whitelaw, C & Wishart, T 2019, ' CRISPR/Cas9 mediated generation of an ovine model for infantile neuronal ceroid lipofuscinosis (CLN1 disease) ', Scientific Reports, vol. 9, 9891 (2019) . https://doi.org/10.1038/s41598-019-45859-9
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-8 (2019)
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-8 (2019)
The neuronal ceroid lipofuscinoses (NCLs) are a group of devastating monogenetic lysosomal disorders that affect children and young adults with no cure or effective treatment currently available. One of the more severe infantile forms of the disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60c9cd67e875b1fb284999f85912a35c
https://doi.org/10.1038/s41598-019-45859-9
https://doi.org/10.1038/s41598-019-45859-9
Autor:
Victoria MacRae, Christopher Bruce Alexander Whitelaw, Hiu-Gwen Tsang, Kim M. Summers, Nabil A Rashdan, Brendan Corcoran
Publikováno v:
Cell Biochemistry and Function. 34:113-132
The human cardiovascular system is a complex arrangement of specialized structures with distinct functions. The molecular landscape, including the genome, transcriptome and proteome, is pivotal to the biological complexity of both normal and abnormal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0fe333a6013013747808e3249054b175
https://doi.org/10.1002/cbf.3173
https://doi.org/10.1002/cbf.3173
Autor:
David C. Hay, Christopher Proudfoot, Christopher Bruce Alexander Whitelaw, Matthew R. Livesey, Ruchi Sharma, Francesc X Donadeu, David J. A. Wyllie
Publikováno v:
Stem Cells and Development. 23:1524-1534
Pluripotent stem cells (PSCs) offer unprecedented biomedical potential not only in relation to humans but also companion animals, particularly the horse. Despite this, attempts to generate bona fide equine embryonic stem cells have been unsuccessful.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2d821d4dedbd2146bd1cbea4813e44c
https://doi.org/10.1089/scd.2013.0565
https://doi.org/10.1089/scd.2013.0565
Autor:
Andrea Catalina Diaz, Audrey Graham, Claire Neil, Ruchi Sharma, Elspeth Milne, Alea Gillian Parham, Amandine Breton, Christopher Bruce Alexander Whitelaw, Francesc X Donadeu
Publikováno v:
Breton, A, Sharma, R, Diaz, A C, Parham, A G, Graham, A, Neil, C, Whitelaw, C B, Milne, E & Donadeu, F X 2013, ' Derivation and Characterization of Induced Pluripotent Stem Cells from Equine Fibroblasts ', Stem Cells and Development, vol. 22, no. 4, pp. 611-621 . https://doi.org/10.1089/scd.2012.0052
Pluripotent stem cells offer unprecedented potential not only for human medicine but also for veterinary medicine, particularly in relation to the horse. Induced pluripotent stem cells (iPSCs) are particularly promising, as they are functionally simi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3baf21440cd7738a9dfef6cfcd5e66d2
https://doi.org/10.1089/scd.2012.0052
https://doi.org/10.1089/scd.2012.0052
Autor:
Tahar Ait-Ali, Alan Archibald, Dequan Xu, Simon G. Lillico, Mark W. Barnett, Christopher Bruce Alexander Whitelaw
Publikováno v:
Xu, D, Lillico, S G, Barnett, M W, Whitelaw, C B A, Archibald, A L & Ait-Ali, T 2012, ' USP18 restricts PRRSV growth through alteration of nuclear translocation of NF-κB p65 and p50 in MARC-145 cells ', Virus Research, vol. 169, no. 1, pp. 264-267 . https://doi.org/10.1016/j.virusres.2012.07.002
Virus Research
Virus Research
Although the functions of porcine respiratory and reproductive syndrome virus (PRRSV) proteins are increasingly understood, the roles of host factors in modifying infection are less well understood. Growing evidence places deubiquitination at the cor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff9296ea944805a498b8712ac1f00d0b
Autor:
Simon G. Lillico, Sandro Cavirani, Valentina Franceschi, Douglas B. Vasey, Gaetano Donofrio, Christopher Bruce Alexander Whitelaw, Antonio Capocefalo
Publikováno v:
Journal of Virological Methods. 161:308-311
BoHV-4 replication cycle is dependent on the S-phase of the cell-cycle at the stage of viral DNA synthesis. Because p21 is a rate-limiting regulator of the G1/S-phase transition and up-regulated by DNA-damaging agents, in this study p21 expression in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e552e9fe780d77ac3c56ca25a4e1a303
https://doi.org/10.1016/j.jviromet.2009.06.012
https://doi.org/10.1016/j.jviromet.2009.06.012
Publikováno v:
Reproduction in Domestic Animals. 43:355-358
Transgenic technology holds considerable promise to advance understanding in biomedical and agricultural systems with some believing that one day transgenic animals may directly contribute to farming and breeding practice. Nevertheless, applications
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::786f3a626d2eee41e8260e91632c152d
https://doi.org/10.1111/j.1439-0531.2008.01184.x
https://doi.org/10.1111/j.1439-0531.2008.01184.x
Autor:
Christopher Bruce Alexander Whitelaw, Lecia L. Pewe, Andreas F. Kolb, Stanley Perlman, John Webster, Stuart G. Siddell
Publikováno v:
Kolb, A F, Pewe, L, Webster, J, Perlman, S, Whitelaw, C B & Siddell, S G 2001, ' Virus-neutralizing monoclonal antibody expressed in milk of transgenic mice provides full protection against virus-induced encephalitis ', Journal of Virology, vol. 75, no. 6, pp. 2803-9 . https://doi.org/10.1128/JVI.75.6.2803-2809.2001
Journal of Virology
Journal of Virology
Neutralizing antibodies represent a major host defense mechanism against viral infections. In mammals, passive immunity is provided by neutralizing antibodies passed to the offspring via the placenta or the milk as immunoglobulin G and secreted immun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e893dd677023765415fab6bcb3d42de4
https://doi.org/10.1128/jvi.75.6.2803-2809.2001
https://doi.org/10.1128/jvi.75.6.2803-2809.2001