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pro vyhledávání: '"Christopher Browning Cole"'
Autor:
Christopher Browning Cole, Maria Pia Morelli, Massimo Fantini, Maria Fergusson, Sharon A. Mavroukakis, Anjum Zaki, Kwong Y. Tsang, Philip Martin Arlen, Christina M. Annunziata
Publikováno v:
Journal of Clinical Oncology. 40:2531-2531
2531 Background: NEO201 is a humanized IgG1 monoclonal antibody generated against tumor-associated antigens from colorectal cancer which binds specifically to tumor-associated CEACAM-5 and CEACAM-6 variants without binding CECAM 5/6 on normal epithel
Publikováno v:
Frontiers in Oncology
Frontiers in Oncology, Vol 10 (2021)
Frontiers in Oncology, Vol 10 (2021)
Ovarian cancer is the leading cause of death among gynecological neoplasms, with an estimated 14,000 deaths in 2019. First-line treatment options center around a taxane and platinum-based chemotherapy regimen. However, many patients often have recurr
Autor:
Christopher Browning Cole, Kwong Y. Tsang, Christina M. Annunziata, Massimo Fantini, Philip M. Arlen
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
BackgroundNEO-201 is an IgG1 mAb reactive against many different human carcinomas expressing the NEO-201 antigen, but not against most normal epithelial tissues. NEO-201 can mediate antitumor activity against tumor cells through multiple mechanisms s