Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Christopher Borowski"'
Autor:
Anca Remes, Dima Ibrahim Basha, Thomas Puehler, Christopher Borowski, Susanne Hille, Laura Kummer, Andreas H. Wagner, Markus Hecker, Jasmin Soethoff, Georg Lutter, Derk Frank, Rawa Arif, Norbert Frey, Marcin Zaradzki, Oliver J. Müller
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 21, Iss , Pp 83-93 (2021)
Gene therapeutic approaches to aortic diseases require efficient vectors and delivery systems for transduction of endothelial cells (ECs) and smooth muscle cells (SMCs). Here, we developed a novel strategy to efficiently deliver a previously describe
Externí odkaz:
https://doaj.org/article/c5e92ee14b7e406480200f11383c9589
Autor:
Jonas Weinmann, Sabrina Weis, Josefine Sippel, Warut Tulalamba, Anca Remes, Jihad El Andari, Anne-Kathrin Herrmann, Quang H. Pham, Christopher Borowski, Susanne Hille, Tanja Schönberger, Norbert Frey, Martin Lenter, Thierry VandenDriessche, Oliver J. Müller, Marinee K. Chuah, Thorsten Lamla, Dirk Grimm
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Adeno-associated virus is the basis of many gene therapies and gene transfer vectors. Here the authors report a pipeline to enable side-by-side comparison of pre-selected capsids in a high throughput manner.
Externí odkaz:
https://doaj.org/article/fcda7a44d2044540880d0f383706efd9
Autor:
Kareen Bartsch, Markus Damme, Tommy Regen, Lore Becker, Lillian Garrett, Sabine M Hölter, Katharina Knittler, Christopher Borowski, Ari Waisman, Markus Glatzel, Helmut Fuchs, Valerie Gailus-Durner, Martin Hrabe de Angelis, Björn Rabe
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Aicardi–Goutières syndrome (AGS) is a rare early onset childhood encephalopathy caused by persistent neuroinflammation of autoimmune origin. AGS is a genetic disorder and >50% of affected individuals bear hypomorphic mutations in ribonuclease H2 (
Externí odkaz:
https://doaj.org/article/524dc7394f8f4eb7b895adc43a3ed3ef
Autor:
Laura Kummer, Norbert Frey, Thomas Puehler, Oliver J. Müller, Derk Frank, Marcin Zaradzki, Susanne Hille, Jasmin Soethoff, Markus Hecker, Andreas H. Wagner, Christopher Borowski, Georg Lutter, Rawa Arif, Dima Ibrahim Basha, Anca Remes
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 21, Iss, Pp 83-93 (2021)
Molecular Therapy. Methods & Clinical Development
Molecular Therapy. Methods & Clinical Development
Gene therapeutic approaches to aortic diseases require efficient vectors and delivery systems for transduction of endothelial cells (ECs) and smooth muscle cells (SMCs). Here, we developed a novel strategy to efficiently deliver a previously describe
Autor:
Dirk Grimm, Josefine Sippel, Quang H Pham, Marinee Chuah, Martin Lenter, Christopher Borowski, Susanne Hille, Oliver J. Müller, Norbert Frey, Jihad El Andari, Jonas Weinmann, Warut Tulalamba, Anca Remes, Thorsten Lamla, Sabrina Weis, Anne-Kathrin Herrmann, Thierry VandenDriessche, Tanja Schönberger
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications
Nature Communications
Adeno-associated virus (AAV) forms the basis for several commercial gene therapy products and for countless gene transfer vectors derived from natural or synthetic viral isolates that are under intense preclinical evaluation. Here, we report a versat
Autor:
Christopher Borowski, Andreas H. Wagner, Norbert Frey, Oliver J. Müller, Maximilian Franz, Marcin Zaradzki, Matthias Karck, Rawa Arif, Anca Remes, Klaus Kallenbach
Publikováno v:
The Journal of Heart and Lung Transplantation. 39:389-398
Allograft vasculopathy (AV) is the primary limiting factor for long-term graft survival. An increased activity of matrix metalloproteinases (MMPs) contributes to neointima formation in AV and represents a potential therapeutic target. Adeno-associate
Autor:
Martina E. Spehlmann, Kareen Bartsch, Konrad Aden, Paul Saftig, Athena Chalaris, Björn Rabe, Christopher Borowski, Markus Damme, Norbert Frey, Sönke Rudnik, Katharina Knittler
Publikováno v:
Human Molecular Genetics. 26:3960-3972
Hypomorphic mutations in the DNA repair enzyme RNase H2 cause the neuroinflammatory autoimmune disorder Aicardi-Goutières syndrome (AGS). Endogenous nucleic acids are believed to accumulate in patient cells and instigate pathogenic type I interferon