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pro vyhledávání: '"Christopher Beneduce"'
Inhibitory Fc-Gamma IIb Receptor Signaling Induced by Multivalent IgG-Fc Is Dependent on Sialylation
Autor:
Christopher Beneduce, Stephanie Nguyen, Nathaniel Washburn, John Schaeck, Robin Meccariello, Kimberly Holte, Daniel Ortiz, Anthony M. Manning, Carlos J. Bosques, Elma Kurtagic
Publikováno v:
Cells, Vol 12, Iss 17, p 2130 (2023)
Immunoglobulin (IgG) Fc glycosylation has been shown to be important for the biological activity of antibodies. Fc sialylation is important for the anti-inflammatory activity of IgGs. However, evaluating the structure–activity relationship (SAR) of
Externí odkaz:
https://doaj.org/article/596cb9d1b1e841fbb5b6fd29af19e280
Publikováno v:
Current topics in microbiology and immunology. 423
Over 80 different autoimmune disorders have been identified. A common denominator across most of these disorders is the presence of pathogenic autoantibodies. The pathogenic and inflammatory nature of antibodies is well accepted, and over the last th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fc7634710cc8695a18b10b633f7fffbd
https://pubmed.ncbi.nlm.nih.gov/30790077
https://pubmed.ncbi.nlm.nih.gov/30790077
Publikováno v:
Current Topics in Microbiology and Immunology ISBN: 9783030310523
Over 80 different autoimmune disorders have been identified. A common denominator across most of these disorders is the presence of pathogenic autoantibodies. The pathogenic and inflammatory nature of antibodies is well accepted, and over the last th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6047d47269d3d9da4735c403bce6a1b1
https://doi.org/10.1007/82_2019_148
https://doi.org/10.1007/82_2019_148
Autor:
Maurice Hains, Kimberly Holte, Amit Choudhury, Daniel Ortiz, Christopher Beneduce, Jonathan C. Lansing, Thomas Prod’homme, Steven Tyler, Robert Prenovitz, Lynn Markowitz, Elma Kurtagic, Allison Simpson, Laura I. Rutitzky, Julia Brown, Leona E. Ling, Stephanie Nguyen, Birgit Schultes, Ishan Capila, Anthony M. Manning, Robin Meccariello, Inessa Schwab, Nathaniel Washburn, Carlos J. Bosques, Matthew A. Child, Radouane Zouaoui, Jason Killough, Falk Nimmerjahn, Jing Wang, Naveen Bhatnagar
Publikováno v:
Science Translational Medicine. 8
Autoantibody immune complex (IC) activation of Fcγ receptors (FcγRs) is a common pathogenic hallmark of multiple autoimmune diseases. Given that the IC structural features that elicit FcγR activation are poorly understood and the FcγR system is h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dccfaa1f5bb42ddec8bfc28ba84dedf7
https://doi.org/10.1126/scitranslmed.aaf9418
https://doi.org/10.1126/scitranslmed.aaf9418