Zobrazeno 1 - 10
of 303
pro vyhledávání: '"Christopher Baum"'
Autor:
Yvonne Knopp, Franziska K. Geis, Dirk Heckl, Stefan Horn, Thomas Neumann, Johannes Kuehle, Janine Meyer, Boris Fehse, Christopher Baum, Michael Morgan, Johann Meyer, Axel Schambach, Melanie Galla
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 13, Iss , Pp 256-274 (2018)
The recently discovered CRISPR/Cas9 system is widely used in basic research and is a useful tool for disease modeling and gene editing therapies. However, long-term expression of DNA-modifying enzymes can be associated with cytotoxicity and is partic
Externí odkaz:
https://doaj.org/article/2595b6871a8e4673b10f1cd8093290c6
Publikováno v:
Viruses, Vol 3, Iss 6, Pp 677-713 (2011)
Retroviruses are evolutionary optimized gene carriers that have naturally adapted to their hosts to efficiently deliver their nucleic acids into the target cell chromatin, thereby overcoming natural cellular barriers. Here we will review—starting w
Externí odkaz:
https://doaj.org/article/7b1b69baf7bb49adad1a5dc26b2c21f5
Autor:
Saskia Kohlscheen, Sabine Wintterle, Adrian Schwarzer, Christel Kamp, Martijn H Brugman, Daniel C Breuer, Guntram Büsche, Christopher Baum, Ute Modlich
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0131866 (2015)
Thrombopoietin (Thpo) signals via its receptor Mpl and regulates megakaryopoiesis, hematopoietic stem cell (HSC) maintenance and post-transplant expansion. Mpl expression is tightly controlled and deregulation of Thpo/Mpl-signaling is linked to hemat
Externí odkaz:
https://doaj.org/article/cec0456968844460ab0b515e4ac5f129
Autor:
Orit Wolstein, Maureen Boyd, Michelle Millington, Helen Impey, Joshua Boyer, Annett Howe, Frederic Delebecque, Kenneth Cornetta, Michael Rothe, Christopher Baum, Tamara Nicolson, Rachel Koldej, Jane Zhang, Naomi Keech, Joanna Camba Colón, Louis Breton, Jeffrey Bartlett, Dong Sung An, Irvin SY Chen, Bryan Burke, Geoff P Symonds
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 1, Iss C (2014)
Gene transfer has therapeutic potential for treating HIV-1 infection by generating cells that are resistant to the virus. We have engineered a novel self-inactivating lentiviral vector, LVsh5/C46, using two viral-entry inhibitors to block early steps
Externí odkaz:
https://doaj.org/article/0729ecc492d941b88e3b1faccdaf1b47
Autor:
Ilona Hauber, Helga Hofmann-Sieber, Jan Chemnitz, Danilo Dubrau, Janet Chusainow, Rolf Stucka, Philip Hartjen, Axel Schambach, Patrick Ziegler, Karl Hackmann, Evelin Schröck, Udo Schumacher, Christoph Lindner, Adam Grundhoff, Christopher Baum, Markus G Manz, Frank Buchholz, Joachim Hauber
Publikováno v:
PLoS Pathogens, Vol 9, Iss 9, p e1003587 (2013)
Stable integration of HIV proviral DNA into host cell chromosomes, a hallmark and essential feature of the retroviral life cycle, establishes the infection permanently. Current antiretroviral combination drug therapy cannot cure HIV infection. Howeve
Externí odkaz:
https://doaj.org/article/a30385a2f1f846a49457496bcee83427
Autor:
Arianna Moiani, Annarita Miccio, Ermanno Rizzi, Marco Severgnini, Danilo Pellin, Julia Debora Suerth, Christopher Baum, Gianluca De Bellis, Fulvio Mavilio
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e55721 (2013)
Moloney murine leukemia virus (MLV)-derived gamma-retroviral vectors integrate preferentially near transcriptional regulatory regions in the human genome, and are associated with a significant risk of insertional gene deregulation. Self-inactivating
Externí odkaz:
https://doaj.org/article/1d374e7e35fd4e15a44900d2ac92c4dc
Autor:
Teng-Cheong Ha, Boris Fehse, Olga S. Kustikova, Violetta Dziadek, Maike Stahlhut, Gabi Paul, Martijn H. Brugman, Axel Schambach, Michael Rothe, Christopher Baum, Michael A. Morgan
Publikováno v:
Human Gene Therapy. 32:458-472
Retroviral insertional mutagenesis (RIM) is both a relevant risk in gene therapy and a powerful tool for identifying genes that enhance the competitiveness of repopulating hematopoietic stem and pr...
Autor:
Boris Fehse, Johann Meyer, Yvonne Knopp, Stefan Horn, Johannes Kuehle, Dirk Heckl, Michael A. Morgan, Franziska K. Geis, Thomas Neumann, Melanie Galla, Axel Schambach, Janine Meyer, Christopher Baum
Publikováno v:
Molecular Therapy. Nucleic Acids
Molecular Therapy: Nucleic Acids, Vol 13, Iss, Pp 256-274 (2018)
Molecular Therapy: Nucleic Acids, Vol 13, Iss, Pp 256-274 (2018)
The recently discovered CRISPR/Cas9 system is widely used in basic research and is a useful tool for disease modeling and gene editing therapies. However, long-term expression of DNA-modifying enzymes can be associated with cytotoxicity and is partic
Autor:
Rebekah Coley, Christopher Baum
The COVID-19 pandemic has led to rising morbidity, mortality, and social and economic disruption, stressors which have impaired mental health.1 Evidence emerged of substantial increases in anxiety and depression in spring and summer, 2020.2-7 To unde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::03ef6a42cf457b69a5e5b665a1a97749
https://doi.org/10.21203/rs.3.rs-146306/v1
https://doi.org/10.21203/rs.3.rs-146306/v1
Autor:
Teng-Cheong, Ha, Maike, Stahlhut, Michael, Rothe, Gabi, Paul, Violetta, Dziadek, Michael, Morgan, Martijn, Brugman, Boris, Fehse, Olga, Kustikova, Axel, Schambach, Christopher, Baum
Publikováno v:
Human gene therapy. 32(9-10)
Retroviral insertional mutagenesis (RIM) is both a relevant risk in gene therapy and a powerful tool for identifying genes that enhance the competitiveness of repopulating hematopoietic stem and progenitor cells (HSPCs). However, focusing only on the