Integration of transcriptomes of senescent cell models with multi-tissue patient samples reveals reduced COL6A3 as an inducer of senescence

Autor: Radoslav Savić, Jialiang Yang, Simon Koplev, Mahru C. An, Priyanka L. Patel, Robert N. O’Brien, Brittany N. Dubose, Tetyana Dodatko, Eduard Rogatsky, Katyayani Sukhavasi, Raili Ermel, Arno Ruusalepp, Sander M. Houten, Jason C. Kovacic, Andrew F. Stewart, Christopher B. Yohn, Eric E. Schadt, Remi-Martin Laberge, Johan L.M. Björkegren, Zhidong Tu, Carmen Argmann

Publikováno v: Cell Reports, Vol 42, Iss 11, Pp 113371- (2023)

Summary: Senescent cells are a major contributor to age-dependent cardiovascular tissue dysfunction, but knowledge of their in vivo cell markers and tissue context is lacking. To reveal tissue-relevant senescence biology, we integrate the transcripto

Externí odkaz: https://doaj.org/article/1c20f6d542d54b86acc9526737df22b2

Iterative screening of an evolutionary engineered Desmodesmus generates robust field strains with pesticide tolerance

Autor: Rebecca A. Ryan, Christopher B. Yohn, Alina A. Corcoran, Philip A. Lee, Salvador Lopez, Matthew A. Saunders, Adam P. Hanley

Publikováno v: Algal Research. 31:443-453

Microalgae hold remarkable promise to produce food, fuel, and nutraceuticals. To satisfy industrial economics, microalgae are commonly cultivated outdoors in open ponds that are subject to invasions by a suite of pests including predators, competitor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d685acbebf873947eada10133105d0a6
https://doi.org/10.1016/j.algal.2018.02.026

Evaluation of phenotype stability and ecological risk of a genetically engineered alga in open pond production

Autor: Jonathan B. Shurin, Michael D. Burkart, Steven Villareal, Nathan G. Schoepp, Christopher B. Yohn, Shawn J. Szyjka, Yan S. Poon, Shovon Mandal, Stephen P. Mayfield, Briana M. Tyler

Publikováno v: Szyjka, SJ; Mandal, S; Schoepp, NG; Tyler, BM; Yohn, CB; Poon, YS; et al.(2017). Evaluation of phenotype stability and ecological risk of a genetically engineered alga in open pond production. ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS, 24, 378-386. doi: 10.1016/j.algal.2017.04.006. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/7vg4r4wv

Genetically engineered (GE) algae offer the promise of producing food, fuel, and other valuable products with reduced requirements for land and fresh water. While the gains in productivity measured in GE terrestrial crops are predicted to be mirrored

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d55dbbea23b4404bd7b33f7962446890
https://escholarship.org/uc/item/7vg4r4wv

l(3)malignant brain tumor and Three Novel Genes Are Required for Drosophila Germ-Cell Formation

Autor: Vitor Barbosa, Leslie Pusateri, Christopher B. Yohn, Ruth Lehmann

Publikováno v: Genetics. 165:1889-1900

To identify genes involved in the process of germ-cell formation in Drosophila, a maternal-effect screen using the FLP/FRT-ovoD method was performed on chromosome 3R. In addition to expected mutations in the germ-cell determinant oskar and in other g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ae9e0bbe39d125025b90b03ad307e11
https://doi.org/10.1093/genetics/165.4.1889

Translation of the Chloroplast psbA mRNA Requires the Nuclear-encoded Poly(A)-binding Protein, RB47

Autor: Stephen P. Mayfield, M. Kuchka, Christopher B. Yohn, Amybeth Cohen, Cristen Rosch

Publikováno v: The Journal of Cell Biology

A set of nuclear mutants of C. reinhardtii were identified that specifically lack translation of the chloroplast-encoded psbA mRNA, which encodes the photosystem II reaction center polypeptide D1. Two of these mutants are deficient in the 47-kD membe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cd15b5f3af150179fc295cecb63bd0d
http://europepmc.org/articles/PMC2133045