Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Christopher B. Pople"'
Autor:
Joshua M. Poulin, Gregory E. Bigford, Krista L. Lanctôt, Peter Giacobbe, Ayal Schaffer, Mark Sinyor, Jennifer S. Rabin, Mario Masellis, Amit Singnurkar, Christopher B. Pople, Nir Lipsman, Muhammad I. Husain, Joshua D. Rosenblat, Xingshan Cao, Bradley J. MacIntosh, Sean M. Nestor
Publikováno v:
Trials, Vol 25, Iss 1, Pp 1-19 (2024)
Abstract Background Major depressive disorder (MDD) is a leading cause of disability worldwide across domains of health and cognition, affecting overall quality of life. Approximately one third of individuals with depression do not fully respond to t
Externí odkaz:
https://doaj.org/article/8958465c86ef44d6807fc658be7eb838
Autor:
Yuexi Huang, Ying Meng, Christopher B. Pople, Allison Bethune, Ryan M. Jones, Agessandro Abrahao, Clement Hamani, Suneil K. Kalia, Lorraine V. Kalia, Nir Lipsman, Kullervo Hynynen
Publikováno v:
Pharmaceutics, Vol 14, Iss 12, p 2607 (2022)
Magnetic resonance-guided focused ultrasound (MRgFUS), in conjunction with circulating microbubbles, is an emerging technology that can transiently enhance the permeability of the blood-brain barrier (BBB) locally and non-invasively to facilitate tar
Externí odkaz:
https://doaj.org/article/c2c534cc2ecb4ce7ba8ddd5945c58e5e
Autor:
Ying Meng, Maged Goubran, Jennifer S Rabin, Melissa McSweeney, Julie Ottoy, Christopher B Pople, Yuexi Huang, Alexandra Storace, Miracle Ozzoude, Allison Bethune, Benjamin Lam, Walter Swardfager, Chinthaka Heyn, Agessandro Abrahao, Benjamin Davidson, Clement Hamani, Isabelle Aubert, Henrik Zetterberg, Nicholas J Ashton, Thomas K Karikari, Kaj Blennow, Sandra E Black, Kullervo Hynynen, Nir Lipsman
Publikováno v:
Brain. 146:865-872
The blood–brain barrier (BBB) protects the brain but is also an important obstacle for the effective delivery of therapeutics in Alzheimer’s disease and other neurodegenerative disorders. Transcranial magnetic resonance-guided focused ultrasound
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::307d800cbcd63cbc43a64114c3a42659
https://doi.org/10.1093/brain/awac459
https://doi.org/10.1093/brain/awac459
Autor:
Ying Meng, Christopher B. Pople, Yuexi Huang, Ryan M. Jones, Julie Ottoy, Maged Goubran, Lais M. Oliveira, Benjamin Davidson, Liam S.P. Lawrence, Angus Z. Lau, Allison Bethune, Pejman Maralani, Agessandro Abrahao, Clement Hamani, Kullervo Hynynen, Suneil K. Kalia, Nir Lipsman, Lorraine V. Kalia
Publikováno v:
Movement Disorders. 37:2134-2139
GBA1 mutation is the most common genetic risk factor for Parkinson's disease (PD). Replacement of the lysosomal enzyme glucocerebrosidase (GCase) slows neurodegeneration in PD models and may be a promising disease-modifying therapy in patients with P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19c83a81b793db0f2a29201cd561f23b
https://doi.org/10.1002/mds.29190
https://doi.org/10.1002/mds.29190
Autor:
Benjamin Davidson, Peter Giacobbe, Tony P. George, Sean M. Nestor, Jennifer S. Rabin, Maged Goubran, Alexander J. Nyman, Anusha Baskaran, Ying Meng, Christopher B. Pople, Simon J. Graham, Fred Tam, Clement Hamani, Nir Lipsman
Publikováno v:
Molecular Psychiatry. 27:3992-4000
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6932b543915181a995b0e1559f6084f6
https://doi.org/10.1038/s41380-022-01677-6
https://doi.org/10.1038/s41380-022-01677-6
Autor:
Dan Budiansky, Ying Meng, Christopher B Pople, Nir Lipsman, Suganth Suppiah, Mary Jane Lim-Fat, Arjun Sahgal, Daniel Li, James Perry
Publikováno v:
Journal of Neuro-Oncology. 156:49-59
Despite manifold advances in oncology, cancers of the central nervous system remain among the most lethal. Unique features of the brain, including distinct cellular composition, immunological privilege, and physical barriers to therapeutic delivery,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::afd7079279d8dfc51fcec27da707702f
https://doi.org/10.1007/s11060-021-03861-0
https://doi.org/10.1007/s11060-021-03861-0
Autor:
David Eapen-John, Ying Meng, Clement Hamani, Christopher B Pople, Nir Lipsman, Peter Giacobbe, Karim Mithani, Jennifer S. Rabin, Xingshan Cao, Benjamin Davidson
Publikováno v:
Journal of Neurology, Neurosurgery & Psychiatry. 93:207-215
BackgroundFour ablative neurosurgical procedures are used in the treatment of refractory psychiatric illness. The long-term effects of these procedures on psychiatric symptoms across disorders has never been synthesised and meta-analysed.MethodsA pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba1bfae326eee9c8e54ecc3bc6086ec3
https://doi.org/10.1136/jnnp-2020-325308
https://doi.org/10.1136/jnnp-2020-325308
Autor:
Ying Meng, Julia Keith, Hon S. Leong, Arun Seth, Yuexi Huang, Kullervo Hynynen, Arjun Sahgal, Chinthaka Heyn, Nir Lipsman, Christopher B Pople, Suganth Suppiah, Maheleth Llinas, Isabelle Aubert, James Perry, Benjamin Davidson, Clement Hamani, Yutaka Amemiya
Publikováno v:
Neuro-Oncology
Background Liquid biopsy is promising for early detection, monitoring of response, and recurrence of cancer. The blood-brain barrier (BBB) limits the shedding of biomarker, such as cell-free DNA (cfDNA), into the blood from brain tumors, and their de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2ab7904476d851a3a2a314372a981c3
http://europepmc.org/articles/PMC8485448
http://europepmc.org/articles/PMC8485448
Autor:
Ying Meng, Christopher B Pople, Suganth Suppiah, Lorraine V. Kalia, Benjamin Davidson, Karim Mithani, Clement Hamani, Daniel Zhengze Li, Michael L. Schwartz, Nadia Scantlebury, Suneil K. Kalia, Luca Bigioni, Nir Lipsman
Publikováno v:
Journal of Neurosurgery. 135:273-278
OBJECTIVE The development of transcranial MR-guided focused ultrasound (MRgFUS) has revitalized the practice of lesioning procedures in functional neurosurgery. Previous health economic analysis found MRgFUS thalamotomy to be a cost-effective treatme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58f5a9b13bbf13adfdebb6879818488f
https://doi.org/10.3171/2020.5.jns20692
https://doi.org/10.3171/2020.5.jns20692
Autor:
James Perry, Ying Meng, Rossanna C. Pezo, Sten Myrehaug, Clement Hamani, Chinthaka Hyen, Arjun Sahgal, Benjamin Davidson, Raymond M. Reilly, Yuexi Huang, Suganth Suppiah, Amit Singnurkar, Nir Lipsman, Maheleth Llinas, Kullervo Hynynen, Christopher B Pople, Maureen E. Trudeau
Publikováno v:
Science translational medicine. 13(615)
The blood-brain barrier (BBB) is an important factor limiting the effectiveness of central nervous system (CNS) therapeutics. MR-guided focused ultrasound (MRgFUS) is a noninvasive, spatially precise technology that enhances drug delivery across a te
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8588774d270b448f1598b4af2196d835
https://pubmed.ncbi.nlm.nih.gov/34644145
https://pubmed.ncbi.nlm.nih.gov/34644145