Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Christopher B. Mulholland"'
Autor:
Christopher B. Mulholland, Atsuya Nishiyama, Joel Ryan, Ryohei Nakamura, Merve Yiğit, Ivo M. Glück, Carina Trummer, Weihua Qin, Michael D. Bartoschek, Franziska R. Traube, Edris Parsa, Enes Ugur, Miha Modic, Aishwarya Acharya, Paul Stolz, Christoph Ziegenhain, Michael Wierer, Wolfgang Enard, Thomas Carell, Don C. Lamb, Hiroyuki Takeda, Makoto Nakanishi, Sebastian Bultmann, Heinrich Leonhardt
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-24 (2020)
Active and passive demethylation pathways have been implicated in the genome-wide erasure of 5mC accompanying mammalian preimplantation development. Here the authors reveal a recently evolved, mammalian-specific pathway in which global hypomethylatio
Externí odkaz:
https://doaj.org/article/de4c9930854d459f81d5177982c48222
Autor:
Atsuya Nishiyama, Christopher B. Mulholland, Sebastian Bultmann, Satomi Kori, Akinori Endo, Yasushi Saeki, Weihua Qin, Carina Trummer, Yoshie Chiba, Haruka Yokoyama, Soichiro Kumamoto, Toru Kawakami, Hironobu Hojo, Genta Nagae, Hiroyuki Aburatani, Keiji Tanaka, Kyohei Arita, Heinrich Leonhardt, Makoto Nakanishi
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Ubiquitylation of histone H3 (H3Ub2) by UHRF1 recruits DNMT1 to chromatin, which is essential for DNA methylation inheritance. Here, the authors provide evidence that there are two distinct mechanisms underlying replication timing-dependent recruitme
Externí odkaz:
https://doaj.org/article/f213b943c175422e80039e7fcf8e3765
Autor:
Gilles Gasparoni, Sebastian Bultmann, Pavlo Lutsik, Theo F. J. Kraus, Sabrina Sordon, Julia Vlcek, Vanessa Dietinger, Martina Steinmaurer, Melanie Haider, Christopher B. Mulholland, Thomas Arzberger, Sigrun Roeber, Matthias Riemenschneider, Hans A. Kretzschmar, Armin Giese, Heinrich Leonhardt, Jörn Walter
Publikováno v:
Epigenetics & Chromatin, Vol 11, Iss 1, Pp 1-19 (2018)
Abstract Background Epigenome-wide association studies (EWAS) based on human brain samples allow a deep and direct understanding of epigenetic dysregulation in Alzheimer’s disease (AD). However, strong variation of cell-type proportions across brai
Externí odkaz:
https://doaj.org/article/1a92d9181b6a46ab9551da0044aec49f
Autor:
Christopher B. Mulholland, Atsuya Nishiyama, Joel Ryan, Ryohei Nakamura, Merve Yiğit, Ivo M. Glück, Carina Trummer, Weihua Qin, Michael D. Bartoschek, Franziska R. Traube, Edris Parsa, Enes Ugur, Miha Modic, Aishwarya Acharya, Paul Stolz, Christoph Ziegenhain, Michael Wierer, Wolfgang Enard, Thomas Carell, Don C. Lamb, Hiroyuki Takeda, Makoto Nakanishi, Sebastian Bultmann, Heinrich Leonhardt
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
A Correction to this paper has been published: https://doi.org/10.1038/s41467-020-20453-0
Externí odkaz:
https://doaj.org/article/a9ee0759a31e47a58878982b9e6289ee
Autor:
Keiichi Hata, Naohiro Kobayashi, Keita Sugimura, Weihua Qin, Deis Haxholli, Yoshie Chiba, Sae Yoshimi, Gosuke Hayashi, Hiroki Onoda, Takahisa Ikegami, Christopher B Mulholland, Atsuya Nishiyama, Makoto Nakanishi, Heinrich Leonhardt, Tsuyoshi Konuma, Kyohei Arita
Ubiquitin-like with PHD and RING finger domain-containing protein 1 (UHRF1)-dependent DNA methylation is essential for maintaining cell fate during cell proliferation. Developmental pluripotency-associated 3 (DPPA3) is an intrinsically disordered pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48457cb67efef24808bd1a3052fc19b4
https://doi.org/10.1101/2022.06.14.496052
https://doi.org/10.1101/2022.06.14.496052
Autor:
Hiroyuki Takeda, Edris Parsa, Joel Ryan, Merve Yiğit, Wolfgang Enard, Carina Trummer, Christoph Ziegenhain, Michael D. Bartoschek, Ivo M. Glück, Franziska R. Traube, Don C. Lamb, Weihua Qin, Sebastian Bultmann, Christopher B. Mulholland, Aishwarya Acharya, Miha Modic, Thomas Carell, Michael Wierer, Heinrich Leonhardt, Enes Ugur, Ryohei Nakamura, Atsuya Nishiyama, Makoto Nakanishi, Paul Stolz
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
A Correction to this paper has been published: https://doi.org/10.1038/s41467-020-20453-0
Autor:
Yasushi Saeki, Carina Trummer, Akinori Endo, Sebastian Bultmann, Soichiro Kumamoto, Kyohei Arita, Atsuya Nishiyama, Genta Nagae, Makoto Nakanishi, Heinrich Leonhardt, Satomi Kori, Weihua Qin, Haruka Yokoyama, Hiroyuki Aburatani, Yoshie Chiba, Christopher B. Mulholland, Keiji Tanaka, Toru Kawakami, Hironobu Hojo
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications
Nature Communications
Stable inheritance of DNA methylation is critical for maintaining differentiated phenotypes in multicellular organisms. We have recently identified dual mono-ubiquitylation of histone H3 (H3Ub2) by UHRF1 as an essential mechanism to recruit DNMT1 to
Autor:
Christopher B. Mulholland, Joel Ryan, Sebastian Bultmann, Weihua Qin, Elisabeth Karg, Heinrich Leonhardt, Georgia Kalideris, Ignasi Forné, Axel Imhof, Martha Smets
Publikováno v:
Journal of Molecular Biology. 429:3814-3824
Ubiquitination is a multifunctional posttranslational modification controlling the activity, subcellular localization and stability of proteins. The E3 ubiquitin ligase ubiquitin-like PHD and RING finger domain-containing protein 1 (UHRF1) is an esse
Autor:
Ivo M. Glück, Hiroyuki Takeda, Carina Trummer, Michael D. Bartoschek, Merve Yiğit, Michael Wierer, Makoto Nakanashi, Sebastian Bultmann, Christopher B. Mulholland, Atsuya Nishiyama, Joel Ryan, Aishwarya Acharya, Don C. Lamb, Christoph Ziegenhain, Thomas Carell, Franziska R. Traube, Edris Parsa, Weihua Qin, Ryohei Nakamura, Heinrich Leonhardt, Enes Ugur, Miha Modic, Wolfgang Enard, Paul Stolz
Genome-wide DNA demethylation is a unique feature of mammalian development and naïve pluripotent stem cells. So far, it was unclear how mammals specifically achieve global DNA hypomethylation, given the high conservation of the DNA (de-)methylation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4da45db0302d0f150b7f37a68afb393
https://doi.org/10.1101/321604
https://doi.org/10.1101/321604
Autor:
Christopher B. Mulholland, Thomas Carell, Sebastian Bultmann, Franziska R. Traube, Edris Parsa, Miha Modic, Joel Ryan, Eva-Maria Eckl, Michael D. Bartoschek, Paul Stolz, Maximillian Schoenung, Heinrich Leonhardt
The TET-oxidized cytosine derivatives, 5-hydroxymethylcytosine (5hmC) and 5-formylcytosine (5fC), are considered DNA demethylation intermediates as well as stable epigenetic marks in mammals. We compared modified cytosine and enzyme levels in TET-kno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8f41e7681b819b7f2b99c6f8134381e