Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Christopher B. Mahony"'
Autor:
Christopher B. Mahony, Rui Monteiro
Publikováno v:
STAR Protocols, Vol 5, Iss 1, Pp 102810- (2024)
Summary: The whole kidney marrow (WKM) is the site for hematopoiesis in the adult zebrafish. Here, we present a protocol for analyzing hematopoietic lineages in the WKM of adult zebrafish. We describe steps for the isolation of hematopoietic cells fr
Externí odkaz:
https://doaj.org/article/ada7826ca6f64427ae6c87e4a8baec66
Autor:
Shanzay Ahmed, Christopher B. Mahony, Alyssa Torres, Jessica Murillo-Saich, Samuel Kemble, Martha Cedeno, Peter John, Attya Bhatti, Adam P. Croft, Monica Guma
Publikováno v:
Arthritis Research & Therapy, Vol 25, Iss 1, Pp 1-15 (2023)
Abstract Background Synovial fibroblasts in rheumatoid arthritis (RAFLS) exhibit a pathological aberration of glycolysis and glutaminolysis. Henceforth, we aimed to investigate if dual inhibition of these pathways by phytobiological compound c28MS ha
Externí odkaz:
https://doaj.org/article/af32fe3ff392445c91651d974582a84f
Autor:
Alyssa Torres, Sarah Kang, Christopher B. Mahony, Martha Cedeño, Patricia G. Oliveira, Marta Fernandez-Bustamante, Samuel Kemble, Teresina Laragione, Percio S. Gulko, Adam P. Croft, Elsa Sanchez-Lopez, Shigeki Miyamoto, Monica Guma
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundGlucose metabolism, specifically, hexokinase 2 (HK2), has a critical role in rheumatoid arthritis (RA) fibroblast-like synoviocyte (FLS) phenotype. HK2 localizes not only in the cytosol but also in the mitochondria, where it protects mitoch
Externí odkaz:
https://doaj.org/article/56bc636062be4eb9b0e55981ccd93727
Autor:
Christopher B. Mahony, Lucy Copper, Pavle Vrljicak, Boris Noyvert, Chrystala Constantinidou, Sofia Browne, Yi Pan, Claire Palles, Sascha Ott, Martin R. Higgs, Rui Monteiro
Publikováno v:
Cell Reports, Vol 42, Iss 6, Pp 112571- (2023)
Summary: Inherited bone marrow failure associated with heterozygous mutations in GATA2 predisposes toward hematological malignancies, but the mechanisms remain poorly understood. Here, we investigate the mechanistic basis of marrow failure in a zebra
Externí odkaz:
https://doaj.org/article/10924ed2ad3f41449b9a5557d42942ee
Autor:
Pietro Cacialli, Christopher B. Mahony, Tim Petzold, Patrizia Bordignon, Anne-Laure Rougemont, Julien Y. Bertrand
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Reactive oxygen species (ROS) are metabolic by-products which in excess can be toxic for hematopoietic stem and progenitor cells (HSPCs). Here the authors show that toxic ROS are transferred by expanding HSPCs to the zebrafish developmental niche via
Externí odkaz:
https://doaj.org/article/d6e3a9bccebb4f0c9f856c6cbade5db4
Autor:
Giuliano Ferrero, Christopher B. Mahony, Eléonore Dupuis, Laurent Yvernogeau, Elodie Di Ruggiero, Magali Miserocchi, Marianne Caron, Catherine Robin, David Traver, Julien Y. Bertrand, Valérie Wittamer
Publikováno v:
Cell Reports, Vol 24, Iss 1, Pp 130-141 (2018)
Summary: Microglia, the tissue-resident macrophages of the CNS, represent major targets for therapeutic intervention in a wide variety of neurological disorders. Efficient reprogramming protocols to generate microglia-like cells in vitro using patien
Externí odkaz:
https://doaj.org/article/172a896c598042bea79e896a8d550db0
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 7 (2019)
Rare hematopoietic stem cells (HSCs) can self-renew, establish the entire blood system and represent the basis of regenerative medicine applied to hematological disorders. Clinical use of HSCs is however limited by their inefficient expansion ex vivo
Externí odkaz:
https://doaj.org/article/8e81e185b5404528b4bbd92223d9f809
Autor:
Bethan Psaila, Kellie R. Machlus, Julie Rayes, Sarah Gooding, Anindita Roy, Gowsihan Poologasundarampillai, David Bassett, Adam P. Croft, Adele K. Fielding, Emily A. Cutler, Samuel Kemble, Andrew P. Stone, Christina Simoglou Karali, Natalina E. Elliott, Rebecca E. Ling, Christopher B. Mahony, Gina Perrella, Beata Grygielska, Lauren C. Murphy, Nikolaos Sousos, Wei Xiong Wen, Guanlin Wang, Michela Colombo, Aude-Anais Olijnik, Jasmeet S. Reyat, Antonio Rodriguez-Romera, Abdullah O. Khan
Supplementary Materials and Methods, Supplementary Figures S1-S12
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a573fe1453225026bed96d9d784dfaf8
https://doi.org/10.1158/2159-8290.22541647.v1
https://doi.org/10.1158/2159-8290.22541647.v1
Autor:
Bethan Psaila, Kellie R. Machlus, Julie Rayes, Sarah Gooding, Anindita Roy, Gowsihan Poologasundarampillai, David Bassett, Adam P. Croft, Adele K. Fielding, Emily A. Cutler, Samuel Kemble, Andrew P. Stone, Christina Simoglou Karali, Natalina E. Elliott, Rebecca E. Ling, Christopher B. Mahony, Gina Perrella, Beata Grygielska, Lauren C. Murphy, Nikolaos Sousos, Wei Xiong Wen, Guanlin Wang, Michela Colombo, Aude-Anais Olijnik, Jasmeet S. Reyat, Antonio Rodriguez-Romera, Abdullah O. Khan
Supplementary Table 3 HD and MPN samples.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::456e3dfa7f46e74c72aebbc2fce7d73a
https://doi.org/10.1158/2159-8290.22541662.v1
https://doi.org/10.1158/2159-8290.22541662.v1
Autor:
Bethan Psaila, Kellie R. Machlus, Julie Rayes, Sarah Gooding, Anindita Roy, Gowsihan Poologasundarampillai, David Bassett, Adam P. Croft, Adele K. Fielding, Emily A. Cutler, Samuel Kemble, Andrew P. Stone, Christina Simoglou Karali, Natalina E. Elliott, Rebecca E. Ling, Christopher B. Mahony, Gina Perrella, Beata Grygielska, Lauren C. Murphy, Nikolaos Sousos, Wei Xiong Wen, Guanlin Wang, Michela Colombo, Aude-Anais Olijnik, Jasmeet S. Reyat, Antonio Rodriguez-Romera, Abdullah O. Khan
Supplementary Table 1 VEGFAC Top Differentially Expressed Genes by Cluster
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92c040ad7afc2e3aecac97e99688b811
https://doi.org/10.1158/2159-8290.22541668
https://doi.org/10.1158/2159-8290.22541668