Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Christopher B. Jackson"'
Autor:
Taru Hilander, Ryan Awadhpersad, Geoffray Monteuuis, Krystyna L. Broda, Max Pohjanpelto, Elizabeth Pyman, Sachin Kumar Singh, Tuula A. Nyman, Isabelle Crevel, Robert W. Taylor, Ann Saada, Diego Balboa, Brendan J. Battersby, Christopher B. Jackson, Christopher J. Carroll
Publikováno v:
iScience, Vol 27, Iss 7, Pp 110185- (2024)
Summary: Mitochondrial ribosomes (mitoribosomes) have undergone substantial evolutionary structural remodeling accompanied by loss of ribosomal RNA, while acquiring unique protein subunits located on the periphery. We generated CRISPR-mediated knocko
Externí odkaz:
https://doaj.org/article/eb4d883dcd61474084b359d3f09df2e4
Autor:
Katarin Gorski, Christopher B. Jackson, Tuula A. Nyman, Veronika Rezov, Brendan J. Battersby, Anna-Elina Lehesjoki
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
The involvement of mitochondrial dysfunction in cystatin B (CSTB) deficiency has been suggested, but its role in the onset of neurodegeneration, myoclonus, and ataxia in the CSTB-deficient mouse model (Cstb−/−) is yet unknown. CSTB is an inhibito
Externí odkaz:
https://doaj.org/article/42d41ce53b244a058994c702cd443e36
Autor:
Philipp Gut, Sanna Matilainen, Jesse G. Meyer, Pieti Pällijeff, Joy Richard, Christopher J. Carroll, Liliya Euro, Christopher B. Jackson, Pirjo Isohanni, Berge A. Minassian, Reem A. Alkhater, Elsebet Østergaard, Gabriele Civiletto, Alice Parisi, Jonathan Thevenet, Matthew J. Rardin, Wenjuan He, Yuya Nishida, John C. Newman, Xiaojing Liu, Stefan Christen, Sofia Moco, Jason W. Locasale, Birgit Schilling, Anu Suomalainen, Eric Verdin
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
The pathomechanism of succinyl-CoA ligase (SCL) deficiency, a hereditary mitochondrial disease, is not fully understood. Here, the authors show that increased succinyl-CoA levels contribute to SCL pathology by causing global protein hyper-succinylati
Externí odkaz:
https://doaj.org/article/21b100a7321c4480b27d69ad8980a816
Autor:
Sarah M. Bandy, Christopher B. Jackson, Cody A. Black, William Godinez, Gerard W. Gawrys, Grace C. Lee
Publikováno v:
Antibiotics, Vol 12, Iss 2, p 210 (2023)
Delays in appropriate antibiotic therapy are a key determinant for deleterious outcomes among patients with vancomycin-resistant Enterococcus (VRE) bloodstream infections (BSIs). This was a multi-center pre/post-implementation study, assessing the im
Externí odkaz:
https://doaj.org/article/fc0a22b6d8484e04a53b44b92a2d75eb
Autor:
Philippe Beauchamp, Christopher B. Jackson, Lijo Cherian Ozhathil, Irina Agarkova, Cristi L. Galindo, Douglas B. Sawyer, Thomas M. Suter, Christian Zuppinger
Publikováno v:
Frontiers in Molecular Biosciences, Vol 7 (2020)
Purpose: Both cardiomyocytes and cardiac fibroblasts (CF) play essential roles in cardiac development, function, and remodeling. Properties of 3D co-cultures are incompletely understood. Hence, 3D co-culture of cardiomyocytes and CF was characterized
Externí odkaz:
https://doaj.org/article/3a3586fc1a7f41ffb064131b5554a5c2
Autor:
Poorya Amini, Darko Stojkov, Andrea Felser, Christopher B. Jackson, Carolina Courage, André Schaller, Laurent Gelman, Maria Eugenia Soriano, Jean-Marc Nuoffer, Luca Scorrano, Charaf Benarafa, Shida Yousefi, Hans-Uwe Simon
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Optic atrophy 1 (OPA1) is known to be important for mitochondrial fusion and structural integrity. Here, using OPA1 knockout mice, the authors show a detrimental effect on host defense capabilities against pathogen infections. This study reports a cr
Externí odkaz:
https://doaj.org/article/d6d65756387f4a38a5e16d6f0ce5f658
Autor:
Olesia Ignatenko, Dmitri Chilov, Ilse Paetau, Elena de Miguel, Christopher B. Jackson, Gabrielle Capin, Anders Paetau, Mugen Terzioglu, Liliya Euro, Anu Suomalainen
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Astrocytes in the brain are metabolically dynamic. Here, Ignatenko, Chilov and colleagues delete mitochondrial DNA (mtDNA) in a cell type specific manner, and show that inactivation of mtDNA helicase Twinkle in astrocytes leads to spongiotic encephal
Externí odkaz:
https://doaj.org/article/8d59af2ffbf5490da6e60f5f6221a5f0
Autor:
Liang Wang, Taru Hilander, Xiaonan Liu, Hoiying Tsang, Ove Eriksson, Christopher B. Jackson, Markku Varjosalo, Hongxia Zhao
Mitochondria contain a multi-copy genome and a distinct set of ribosomes devoted to the exclusive synthesis of proteins that are essential for oxidative phosphorylation. The assembly of mitoribosomes for mitochondrial translation is a poorly understo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3e13969e7f7434c012b201ff5b57091
https://doi.org/10.1101/2023.05.26.542385
https://doi.org/10.1101/2023.05.26.542385
Autor:
Ranjit S. Bindra, Jann N. Sarkaria, Oren Gilad, Danielle M. Burgenske, Hank Breslin, Lanqi Jia, Sachita Ganesa, Aravind N. Kalathil, Ranjini K. Sundaram, Seth I. Noorbakhsh, Christopher B. Jackson
All supplemental figures and captions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23fa96e560d0cca77ff3e221395cc9ab
https://doi.org/10.1158/0008-5472.22421270
https://doi.org/10.1158/0008-5472.22421270
Autor:
Ranjit S. Bindra, Jann N. Sarkaria, Oren Gilad, Danielle M. Burgenske, Hank Breslin, Lanqi Jia, Sachita Ganesa, Aravind N. Kalathil, Ranjini K. Sundaram, Seth I. Noorbakhsh, Christopher B. Jackson
O6-methylguanine-DNA methyltransferase (MGMT) is an enzyme that removes alkyl groups at the O6-position of guanine in DNA. MGMT expression is reduced or absent in many tumor types derived from a diverse range of tissues, most notably in glioma. Low M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e9906923a36ee468eb5b64da94f258d
https://doi.org/10.1158/0008-5472.c.6510875.v1
https://doi.org/10.1158/0008-5472.c.6510875.v1